- 関
- vecuronium
WordNet
- any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs
PrepTutorEJDIC
- 〈U〉臭化物(鎮静剤・睡眠剤として用いる) / 〈C〉《話》陳腐なことば
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/18 00:37:12」(JST)
[Wiki en表示]
Vecuronium bromide
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| Systematic (IUPAC) name |
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17S)-
17-acetyloxy-10,13-dimethyl-16-(1-methyl-3,4,
5,6-tetrahydro-2H-pyridin-1-yl)-2-(1-piperidyl)-
2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-
1H-cyclopenta[a]phenanthren-3-yl] acetate |
| Clinical data |
| AHFS/Drugs.com |
monograph |
| Pregnancy cat. |
C (US) |
| Legal status |
℞-only (US) |
| Routes |
Intravenous |
| Pharmacokinetic data |
| Bioavailability |
100% (IV) |
| Metabolism |
liver 30% |
| Half-life |
51–80 minutes (longer with renal failure) |
| Excretion |
Fecal (40-75%) and renal (30% as unchanged drug and metabolites) |
| Identifiers |
| CAS number |
50700-72-6 Y |
| ATC code |
M03AC03 |
| PubChem |
CID 39765 |
| UNII |
7E4PHP5N1D N |
| ChEMBL |
CHEMBL1201219 N |
| Chemical data |
| Formula |
C34H57N2O4+ |
| Mol. mass |
557.827 g/mol |
N (what is this?) (verify)
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Vecuronium (Norcuron) is a muscle relaxant in the category of non-depolarizing blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent. It is commercially available as ampoules containing 4 or 10 mg of the drug in powder form which needs to be dissolved in distilled water prior to administration to the patient.
Contents
- 1 Development
- 2 Clinical pharmacology
- 3 Media
- 4 References
Development[edit]
Vecuronium's structure is derived from the same aminosteroid structure as pancuronium, but it is missing the methyl group on the piperidine nitrogen that is attached to the 'A' ring, making it monoquaternary, like D-tubocurarine. It has the same configuration at all ten stereocentres as pancuronium, and is a single-isomer preparation.
Clinical pharmacology[edit]
Vecuronium operates by competing for the cholinoceptors at the motor end plate thereby exerting its muscle-relaxing properties which are used adjunctively to general anesthesia. Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes after injection and recovery is usually 95% complete approximately 45 to 65 minutes after injection of intubating dose. The neuromuscular blocking action of vecuronium is slightly enhanced in the presence of potent inhalation anesthetics. If vecuronium is first administered more than 5 minutes after the start of the inhalation of enflurane, isoflurane, or halothane, or when a steady state has been achieved, the intubating dose of vecuronium may be decreased by approximately 15%.
Vecuronium is an aminosteroid.
Media[edit]
In 2001, Japanese nurse Daisuke Mori was reported to have murdered 10 patients using vecuronium bromide.[1] He was convicted of murder and was sentenced to life imprisonment.[2]
References[edit]
- ^ "Japanese nurse kills 10 patients, says wanted to trouble hospital". The Indian Express. 2001-01-10. Retrieved 2008-03-22.
- ^ "Nurse gets life for patient slaying". The Japan Times Weekly. April 10, 2004. Retrieved October 26, 2011.
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Skeletal muscle relaxants (M03)
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Peripherally acting
(primarily antinicotinic,
NMJ block) |
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Non-depolarizing
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Curare alkaloids
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- Alcuronium
- Dimethyltubocurarine
- Tubocurarine
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4° ammonium agents
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- ultra-short duration: Gantacurium
- short duration: Mivacurium
- Chandonium
- intermediate duration: Atracurium
- Cisatracurium
- Fazadinium
- Rocuronium
- Vecuronium
- long duration: Doxacurium
- Dimethyltubocurarine
- Pancuronium
- Pipecuronium
- Laudexium
- Gallamine
- unsorted: Hexafluronium (Hexafluorenium)
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Depolarizing
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- Choline derivatives: Suxamethonium (Succinylcholine)
- Polyalkylene derivatives: Hexamethonium
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ACh release inhibitors
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| Centrally acting |
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Carbamic acid esters
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- Carisoprodol
- Cyclarbamate
- Difebarbamate
- Febarbamate
- Meprobamate
- Methocarbamol
- Phenprobamate
- Styramate
- Tybamate
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Benzodiazepines
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- Bentazepam
- Bromazepam
- Diazepam
- Clonazepam
- Flunitrazepam
- Lorazepam
- Nitrazepam
- Tetrazepam
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Nonbenzodiazepines
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Thienodiazepines
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Quinazolines
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Anticholinergics (Antimuscarinics)
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- Cyclobenzaprine
- Orphenadrine
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Other
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- Arbaclofen placarbil
- Baclofen
- Chlormezanone
- Chlorphenesin
- Chlorzoxazone
- Donepezil
- Eperisone
- Fenyramidol
- Flopropione
- GHB
- Mephenesin
- Mephenoxalone
- Metaxalone
- Phenibut
- Pridinol
- Promoxolane
- Quinine
- Thiocolchicoside
- Tizanidine
- Tolperisone
- Trazodone
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| Directly acting |
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anat (h/n, u, t/d, a/p, l)/phys/devp/hist
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noco (m, s, c)/cong (d)/tumr, sysi/epon, injr
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Cholinergics
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Receptor ligands
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mAChR
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- Agonists: 77-LH-28-1
- AC-42
- AC-260,584
- Aceclidine
- Acetylcholine
- AF30
- AF150(S)
- AF267B
- AFDX-384
- Alvameline
- AQRA-741
- Arecoline
- Bethanechol
- Butyrylcholine
- Carbachol
- CDD-0034
- CDD-0078
- CDD-0097
- CDD-0098
- CDD-0102
- Cevimeline
- Choline
- cis-Dioxolane
- Ethoxysebacylcholine
- LY-593,039
- L-689,660
- LY-2,033,298
- McNA343
- Methacholine
- Milameline
- Muscarine
- NGX-267
- Ocvimeline
- Oxotremorine
- PD-151,832
- Pilocarpine
- RS86
- Sabcomeline
- SDZ 210-086
- Sebacylcholine
- Suberylcholine
- Talsaclidine
- Tazomeline
- Thiopilocarpine
- Vedaclidine
- VU-0029767
- VU-0090157
- VU-0152099
- VU-0152100
- VU-0238429
- WAY-132,983
- Xanomeline
- YM-796
Antagonists: 3-Quinuclidinyl Benzilate
- 4-DAMP
- Aclidinium Bromide
- Anisodamine
- Anisodine
- Atropine
- Atropine Methonitrate
- Benactyzine
- Benzatropine/Benztropine
- Benzydamine
- BIBN 99
- Biperiden
- Bornaprine
- CAR-226,086
- CAR-301,060
- CAR-302,196
- CAR-302,282
- CAR-302,368
- CAR-302,537
- CAR-302,668
- CS-27349
- Cyclobenzaprine
- Cyclopentolate
- Darifenacin
- DAU-5884
- Dimethindene
- Dexetimide
- DIBD
- Dicyclomine/Dicycloverine
- Ditran
- EA-3167
- EA-3443
- EA-3580
- EA-3834
- Etanautine
- Etybenzatropine/Ethylbenztropine
- Flavoxate
- Himbacine
- HL-031,120
- Ipratropium bromide
- J-104,129
- Hyoscyamine
- Mamba Toxin 3
- Mamba Toxin 7
- Mazaticol
- Mebeverine
- Methoctramine
- Metixene
- N-Ethyl-3-Piperidyl Benzilate
- N-Methyl-3-Piperidyl Benzilate
- Orphenadrine
- Otenzepad
- Oxybutynin
- PBID
- PD-102,807
- PD-0298029
- Phenglutarimide
- Phenyltoloxamine
- Pirenzepine
- Piroheptine
- Procyclidine
- Profenamine
- RU-47,213
- SCH-57,790
- SCH-72,788
- SCH-217,443
- Scopolamine/Hyoscine
- Solifenacin
- Telenzepine
- Tiotropium bromide
- Tolterodine
- Trihexyphenidyl
- Tripitamine
- Tropatepine
- Tropicamide
- WIN-2299
- Xanomeline
- Zamifenacin; Others: 1st Generation Antihistamines (Brompheniramine
- chlorphenamine
- cyproheptadine
- dimenhydrinate
- diphenhydramine
- doxylamine
- mepyramine/pyrilamine
- phenindamine
- pheniramine
- tripelennamine
- triprolidine, etc)
- Tricyclic Antidepressants (Amitriptyline
- doxepin
- trimipramine, etc)
- Tetracyclic Antidepressants (Amoxapine
- maprotiline, etc)
- Typical Antipsychotics (Chlorpromazine
- thioridazine, etc)
- Atypical Antipsychotics (Clozapine
- olanzapine, etc.)
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nAChR
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- Agonists: 5-HIAA
- A-84,543
- A-366,833
- A-582,941
- A-867,744
- ABT-202
- ABT-418
- ABT-560
- ABT-894
- Acetylcholine
- Altinicline
- Anabasine
- Anatoxin-a
- AR-R17779
- Butinoline
- Butyrylcholine
- Carbachol
- Choline
- Cotinine
- Cytisine
- Decamethonium
- Desformylflustrabromine
- Dianicline
- Dimethylphenylpiperazinium
- Epibatidine
- Epiboxidine
- Ethanol
- Ethoxysebacylcholine
- EVP-4473
- EVP-6124
- Galantamine
- GTS-21
- Ispronicline
- Lobeline
- MEM-63,908/RG-3487
- Nicotine
- NS-1738
- PHA-543,613
- PHA-709,829
- PNU-120,596
- PNU-282,987
- Pozanicline
- Rivanicline
- RJR-2429
- Sazetidine A
- Sebacylcholine
- SIB-1508Y
- SIB-1553A
- SSR-180,711
- Suberylcholine
- Suxamethonium/Succinylcholine
- TC-1698
- TC-1734
- TC-1827
- TC-2216
- TC-5214
- TC-5619
- TC-6683
- Tebanicline
- Tropisetron
- UB-165
- Varenicline
- WAY-317,538
- XY-4083
Antagonists: 18-Methoxycoronaridine
- α-Bungarotoxin
- α-Conotoxin
- Alcuronium
- Amantadine
- Anatruxonium
- Atracurium
- Bupropion
- Chandonium
- Chlorisondamine
- Cisatracurium
- Coclaurine
- Coronaridine
- Dacuronium
- Decamethonium
- Dextromethorphan
- Dextropropoxyphene
- Dextrorphan
- Diadonium
- DHβE
- Dimethyltubocurarine/Metocurine
- Dipyrandium
- Dizocilpine/MK-801
- Doxacurium
- Duador
- Esketamine
- Fazadinium
- Gallamine
- Hexafluronium
- Hexamethonium/Benzohexonium
- Ibogaine
- Isoflurane
- Ketamine
- Kynurenic acid
- Laudexium/Laudolissin
- Levacetylmethadol
- Malouetine
- Mecamylamine
- Memantine
- Methadone (Levomethadone)
- Methorphan/Racemethorphan
- Methyllycaconitine
- Metocurine
- Mivacurium
- Morphanol/Racemorphan
- Neramexane
- Nitrous Oxide
- Pancuronium
- Pempidine
- Pentamine
- Pentolinium
- Phencyclidine
- Pipecuronium
- Radafaxine
- Rapacuronium
- Rocuronium
- Surugatoxin
- Thiocolchicoside
- Toxiferine
- Trimethaphan
- Tropeinium
- Tubocurarine
- Vecuronium
- Xenon
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Reuptake inhibitors
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Plasmalemmal
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CHT Inhibitors
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- Hemicholinium-3/Hemicholine
- Triethylcholine
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Vesicular
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Enzyme inhibitors
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Anabolism
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ChAT inhibitors
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- 1-(-Benzoylethyl)pyridinium
- 2-(α-Naphthoyl)ethyltrimethylammonium
- 3-Chloro-4-stillbazole
- 4-(1-Naphthylvinyl)pyridine
- Acetylseco hemicholinium-3
- Acryloylcholine
- AF64A
- B115
- BETA
- CM-54,903
- N,N-Dimethylaminoethylacrylate
- N,N-Dimethylaminoethylchloroacetate
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Catabolism
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AChE inhibitors
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BChE inhibitors
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- Cymserine * Many of the acetylcholinesterase inhibitors listed above act as butyrylcholinesterase inhibitors.
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Others
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Precursors
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- Choline (Lecithin)
- Citicoline
- Cyprodenate
- Dimethylethanolamine
- Glycerophosphocholine
- Meclofenoxate/Centrophenoxine
- Phosphatidylcholine
- Phosphatidylethanolamine
- Phosphorylcholine
- Pirisudanol
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Cofactors
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- Acetic acid
- Acetylcarnitine
- Acetyl-coA
- Vitamin B5 (Pantethine
- Pantetheine
- Panthenol)
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Others
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- Acetylcholine releasing agents: α-Latrotoxin
- β-Bungarotoxin; Acetylcholine release inhibitors: Botulinum toxin (Botox); Acetylcholinesterase reactivators: Asoxime
- Obidoxime
- Pralidoxime
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UpToDate Contents
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English Journal
- Effect of bolus injection of 20 ml saline with arm elevation on the onset time of vecuronium administered via a peripheral vein: a randomised controlled trial.
- Nitahara K, Sugi Y, Shigematsu K, Kusumoto G, Abe S, Higa K.SourceDepartment of Anesthesiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
- Anaesthesia.Anaesthesia.2013 Sep;68(9):904-7. doi: 10.1111/anae.12333. Epub 2013 Jun 21.
- We investigated whether a bolus injection of 20 ml saline with arm elevation might shorten the onset time of vecuronium administered via a dorsal hand vein. Thirty patients were randomly allocated to the bolus saline group or control group. General anaesthesia was induced and maintained with remifen
- PMID 23789813
- Impact of preoperative anticonvulsant therapy on vecuronium-induced neuromuscular block under sevoflurane anesthesia: a retrospective clinical study.
- Kawamura G, Kitamura T, Ohno N, Tashiro Y, Asahara M, Sato K, Yamada Y.SourceDepartment of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655.
- Masui. The Japanese journal of anesthesiology.Masui.2013 Aug;62(8):935-8.
- PMID 23984567
- [Effect of transcutaneous acupoint electric stimulation on perioperative intravenous anesthesia in patients of transsphenoidal pituitary tumor resection].
- Chen X, Wang BG, Li J, An LX.SourceDepartment of Anesthesiology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China.
- Zhongguo zhen jiu = Chinese acupuncture & moxibustion.Zhongguo Zhen Jiu.2013 Aug;33(8):732-6.
- OBJECTIVE: To observe the impacts of transcutaneous acupoint electric stimulation on hemodynamics, anesthetic and relevant complications in patients of transsphenoidal pituitary tumor resection (TPTR).METHODS: Ninety cases of the selective TPTR were randomized into a transcutaneous acupoint electric
- PMID 24195218
Japanese Journal
- Effects of Intraoperative Magnetic Resonance Imaging on the Neuromuscular Blockade of Vecuronium Bromide in Neurosurgery
- GUO Ying,ZHANG Hong,SUN Li
- Neurologia medico-chirurgica = 神経外科 53(4), 201-206, 2013-04-15
- NAID 10031151330
- Effects of Intraoperative Magnetic Resonance Imaging on the Neuromuscular Blockade of Vecuronium Bromide in Neurosurgery
- GUO Ying,ZHANG Hong,SUN Li
- Neurologia medico-chirurgica 53(4), 201-206, 2013
- … The effects of intraoperative magnetic resonance (iMR) imaging on the neuromuscular blockade of vecuronium bromide were investigated in neurosurgery. … Train-of-four (TOF) stimulation through an accelerometer was used to monitor onset, maintenance, and recovery of muscle relaxation caused by vecuronium. … Vecuronium bromide was intravenously injected after anesthesia induction. …
- NAID 130003364229
- 全身麻酔覚醒後に過換気症候群を発症した局所麻酔アレルギー様反応の既往を持つ患者の1症例
- 藤原 茂樹,矢尾 直明,高野 貴司,向澤 舞,長縄 鋼亮,江原 雄一,笠井 唯克,高倉 康
- 岐阜歯科学会雑誌 37(2), 118-120, 2010-10-20
- 歯科治療中に遭遇する偶発症の1つに過換気症候群(Hyper Ventilation Syndrome:HVS)がある.HVSは原因となる器質的疾患がなく,過度な不安や緊張の心因性素因から発症することが多い.今回,局所麻酔アレルギー様反応の既往を持つ患者に対し全身麻酔を行った.アレルギー反応を惹起させないために,麻酔導入と維持は比較的アレルゲンになりにくいセボフルラン,気管挿管時にはヒスタミンの遊離 …
- NAID 110007810395
Related Links
- Pfizer Laboratories Div Pfizer Inc: Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide... ... DESCRIPTION Vecuronium Bromide for Injection is a nondepolarizing ...
- Vecuronium Bromide , Find Complete Details about Vecuronium Bromide,Vecuronium Bromide from Central Nervous System Agents Supplier or Manufacturer-SWAPNROOP DRUGS & PHARMACEUTICALS ... Name: Vecuronium ...
★リンクテーブル★
[★]
- 英
- vecuronium
- 化
- 臭化ベクロニウム vecuronium bromide Vb
- 商
- マスキュラックス
- 関
- 筋弛緩薬
[★]
ベクロニウム。臭化ベクロニウム vecuronium bromideの略
[★]
[★]
ベクロニウム
- 同
- Norcuron
[★]