臭化ベクロニウム

関: vecuronium

WordNet

any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs

PrepTutorEJDIC

〈U〉臭化物(鎮静剤・睡眠剤として用いる) / 〈C〉《話》陳腐なことば

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/18 00:37:12」(JST)

wiki en

[Wiki en表示]

Vecuronium (Norcuron) is a muscle relaxant in the category of non-depolarizing blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent. It is commercially available as ampoules containing 4 or 10 mg of the drug in powder form which needs to be dissolved in distilled water prior to administration to the patient.

Development[edit]

Vecuronium's structure is derived from the same aminosteroid structure as pancuronium, but it is missing the methyl group on the piperidine nitrogen that is attached to the 'A' ring, making it monoquaternary, like D-tubocurarine. It has the same configuration at all ten stereocentres as pancuronium, and is a single-isomer preparation.

Clinical pharmacology[edit]

Vecuronium operates by competing for the cholinoceptors at the motor end plate thereby exerting its muscle-relaxing properties which are used adjunctively to general anesthesia. Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes after injection and recovery is usually 95% complete approximately 45 to 65 minutes after injection of intubating dose. The neuromuscular blocking action of vecuronium is slightly enhanced in the presence of potent inhalation anesthetics. If vecuronium is first administered more than 5 minutes after the start of the inhalation of enflurane, isoflurane, or halothane, or when a steady state has been achieved, the intubating dose of vecuronium may be decreased by approximately 15%.

Vecuronium is an aminosteroid.

Media[edit]

In 2001, Japanese nurse Daisuke Mori was reported to have murdered 10 patients using vecuronium bromide.^[1] He was convicted of murder and was sentenced to life imprisonment.^[2]

References[edit]

^ "Japanese nurse kills 10 patients, says wanted to trouble hospital". The Indian Express. 2001-01-10. Retrieved 2008-03-22.
^ "Nurse gets life for patient slaying". The Japan Times Weekly. April 10, 2004. Retrieved October 26, 2011.

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. Induction of general anesthesia
2. 眼の待機手術に対する麻酔 anesthesia for elective eye surgery
3. 全身麻酔導入における気道管理 airway management for induction of general anesthesia
4. 重症患者における神経筋遮断剤の使用 use of neuromuscular blocking medications in critically ill patients
5. 小児に対する急速挿管法（RSI） rapid sequence intubation rsi in children

English Journal

Effect of bolus injection of 20 ml saline with arm elevation on the onset time of vecuronium administered via a peripheral vein: a randomised controlled trial.

Nitahara K, Sugi Y, Shigematsu K, Kusumoto G, Abe S, Higa K.SourceDepartment of Anesthesiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Anaesthesia.Anaesthesia.2013 Sep;68(9):904-7. doi: 10.1111/anae.12333. Epub 2013 Jun 21.
We investigated whether a bolus injection of 20 ml saline with arm elevation might shorten the onset time of vecuronium administered via a dorsal hand vein. Thirty patients were randomly allocated to the bolus saline group or control group. General anaesthesia was induced and maintained with remifen
PMID 23789813

Impact of preoperative anticonvulsant therapy on vecuronium-induced neuromuscular block under sevoflurane anesthesia: a retrospective clinical study.

Kawamura G, Kitamura T, Ohno N, Tashiro Y, Asahara M, Sato K, Yamada Y.SourceDepartment of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655.
Masui. The Japanese journal of anesthesiology.Masui.2013 Aug;62(8):935-8.
PMID 23984567

[Effect of transcutaneous acupoint electric stimulation on perioperative intravenous anesthesia in patients of transsphenoidal pituitary tumor resection].

Chen X, Wang BG, Li J, An LX.SourceDepartment of Anesthesiology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China.
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.Zhongguo Zhen Jiu.2013 Aug;33(8):732-6.
OBJECTIVE: To observe the impacts of transcutaneous acupoint electric stimulation on hemodynamics, anesthetic and relevant complications in patients of transsphenoidal pituitary tumor resection (TPTR).METHODS: Ninety cases of the selective TPTR were randomized into a transcutaneous acupoint electric
PMID 24195218

Japanese Journal

Effects of Intraoperative Magnetic Resonance Imaging on the Neuromuscular Blockade of Vecuronium Bromide in Neurosurgery

GUO Ying,ZHANG Hong,SUN Li
Neurologia medico-chirurgica = 神経外科 53(4), 201-206, 2013-04-15
NAID 10031151330

Effects of Intraoperative Magnetic Resonance Imaging on the Neuromuscular Blockade of Vecuronium Bromide in Neurosurgery

GUO Ying,ZHANG Hong,SUN Li
Neurologia medico-chirurgica 53(4), 201-206, 2013
… The effects of intraoperative magnetic resonance (iMR) imaging on the neuromuscular blockade of vecuronium bromide were investigated in neurosurgery. … Train-of-four (TOF) stimulation through an accelerometer was used to monitor onset, maintenance, and recovery of muscle relaxation caused by vecuronium. … Vecuronium bromide was intravenously injected after anesthesia induction. …
NAID 130003364229

全身麻酔覚醒後に過換気症候群を発症した局所麻酔アレルギー様反応の既往を持つ患者の1症例

藤原茂樹,矢尾直明,高野貴司,向澤舞,長縄鋼亮,江原雄一,笠井唯克,高倉康
岐阜歯科学会雑誌 37(2), 118-120, 2010-10-20
歯科治療中に遭遇する偶発症の1つに過換気症候群(Hyper Ventilation Syndrome:HVS)がある.HVSは原因となる器質的疾患がなく,過度な不安や緊張の心因性素因から発症することが多い.今回,局所麻酔アレルギー様反応の既往を持つ患者に対し全身麻酔を行った.アレルギー反応を惹起させないために,麻酔導入と維持は比較的アレルゲンになりにくいセボフルラン,気管挿管時にはヒスタミンの遊離 …
NAID 110007810395

Related Pictures

★リンクテーブル★

リンク元	「ベクロニウム」「Vb」
関連記事	「bromide」「vecuronium」「bromides」

「ベクロニウム」

Vecuronium bromide
Systematic (IUPAC) name
	[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17S)-; 17-acetyloxy-10,13-dimethyl-16-(1-methyl-3,4,; 5,6-tetrahydro-2H-pyridin-1-yl)-2-(1-piperidyl)-; 2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-; 1H-cyclopenta[a]phenanthren-3-yl] acetate
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Intravenous
Pharmacokinetic data
Bioavailability	100% (IV)
Metabolism	liver 30%
Half-life	51–80 minutes (longer with renal failure)
Excretion	Fecal (40-75%) and renal (30% as unchanged drug and metabolites)
Identifiers
CAS number	50700-72-6
ATC code	M03AC03
PubChem	CID 39765
UNII	7E4PHP5N1D
ChEMBL	CHEMBL1201219
Chemical data
Formula	C34H57N2O4+
Mol. mass	557.827 g/mol
(what is this?) (verify);

　　[★]

英: vecuronium
化: 臭化ベクロニウム vecuronium bromide Vb
商: マスキュラックス
関: 筋弛緩薬

非脱分極性筋弛緩薬

「Vb」

　　[★] ベクロニウム。臭化ベクロニウム vecuronium bromideの略

「bromide」

　　[★]

n.

臭化物、ブロム剤

「vecuronium」

　　[★] ベクロニウム

同: Norcuron

「bromides」

　　[★]

n.

臭化物、ブロム剤

[1] "Japanese nurse kills 10 patients, says wanted to trouble hospital". The Indian Express. 2001-01-10. Retrieved 2008-03-22.

[2] "Nurse gets life for patient slaying". The Japan Times Weekly. April 10, 2004. Retrieved October 26, 2011.

匿名

検索

案内

案内

vecuronium bromide