- 関
- VIP receptor
WordNet
- of or relating to or inside the intestines; "intestinal disease" (同)enteric, enteral
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein
PrepTutorEJDIC
- 腸[内]の
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/01 20:29:30」(JST)
[Wiki en表示]
| vasoactive intestinal peptide receptor 1 |
| Identifiers |
| Symbol |
VIPR1 |
| Alt. symbols |
RDC1, HVR1, VAPC1 |
| Entrez |
7433 |
| HUGO |
12694 |
| OMIM |
192321 |
| RefSeq |
NM_004624 |
| UniProt |
P32241 |
| Other data |
| Locus |
Chr. 3 p22 |
| vasoactive intestinal peptide receptor 2 |
| Identifiers |
| Symbol |
VIPR2 |
| Alt. symbols |
VPAC2 |
| Entrez |
7434 |
| HUGO |
12695 |
| OMIM |
601970 |
| RefSeq |
NM_003382 |
| UniProt |
P41587 |
| Other data |
| Locus |
Chr. 7 q36.3 |
| adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
| Identifiers |
| Symbol |
ADCYAP1R1 |
| Alt. symbols |
PACAPR |
| Entrez |
117 |
| HUGO |
242 |
| OMIM |
102981 |
| RefSeq |
NM_001118 |
| UniProt |
P41586 |
| Other data |
| Locus |
Chr. 7 p14 |
There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2.[1][2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family.
VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.
VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.[3]
References[edit]
- ^ Laburthe M, Couvineau A, Marie JC (2002). "VPAC receptors for VIP and PACAP". Recept. Channels 8 (3-4): 137–53. doi:10.1080/10606820213680. PMID 12529932.
- ^ Laburthe M, Couvineau A (2002). "Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP". Regul. Pept. 108 (2-3): 165–73. doi:10.1016/S0167-0115(02)00099-X. PMID 12220741.
- ^ "VIP and PACAP receptors". IUPHAR Guide to Pharmacology. The British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR).
External links[edit]
- "VIP and PACAP Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Receptors, Vasoactive Intestinal Peptide at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Cell surface receptor: G protein-coupled receptors
|
|
Class A:
Rhodopsin like |
|
|
| Class B: Secretin like |
|
Orphan
|
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
|
|
|
Other
|
- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
|
|
|
Class C: Metabotropic
glutamate / pheromone |
|
Taste
|
- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
|
|
|
Other
|
- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
|
|
|
Class F:
Frizzled / Smoothened |
|
Frizzled
|
- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
|
|
|
Smoothened
|
|
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
|
Neuropeptide receptors
|
|
| G protein-coupled receptor |
|
Hormone receptors
|
|
Hypothalamic
|
CRH · FSH · LHRH · TRH · Somatostatin
|
|
|
Pituitary
|
Vasopressin (1A, 1B, 2) · Oxytocin · LHCG · TSH
|
|
|
Other
|
Atrial natriuretic factor (NPR3) · Calcitonin · Cholecystokinin (A, B) · VIP
|
|
|
|
Opioid receptors
|
Delta · Kappa · Mu · Nociceptin
|
|
|
Other neuropeptide receptors
|
Angiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · Neurotensin
|
|
|
| Type I cytokine receptor |
GH · Prolactin
|
|
| Enzyme-linked receptor |
Atrial natriuretic factor (NPR1, NPR2)
|
|
| Other |
Sigma (1, 2)
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
UpToDate Contents
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English Journal
- Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist.
- Ago Y1, Condro MC, Tan YV, Ghiani CA, Colwell CS, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.
- Psychopharmacology.Psychopharmacology (Berl).2015 Jun;232(12):2181-9. doi: 10.1007/s00213-014-3848-z. Epub 2015 Jan 11.
- RATIONALE: An abundance of genetic and epidemiologic evidence as well as longitudinal neuroimaging data point to developmental origins for schizophrenia and other mental health disorders. Recent clinical studies indicate that microduplications of VIPR2, encoding the vasoactive intestinal peptide (VI
- PMID 25575489
- Incretin-based therapies: where will we be 50 years from now?
- Meier JJ1, Nauck MA.
- Diabetologia.Diabetologia.2015 May 21. [Epub ahead of print]
- The development of incretin-based therapies (glucagon-like peptide 1 [GLP-1] receptor agonists and dipeptidyl peptidase-4 [DPP-4] inhibitors) has changed the landscape of type 2 diabetes management over the past decade. Current developments include longer-acting GLP-1 receptor agonists, fixed-ratio
- PMID 25994073
- Electroacupuncture attenuates collagen-induced arthritis in rats through vasoactive intestinal peptide signalling-dependent re-establishment of the regulatory T cell/T-helper 17 cell balance.
- Zhu J1, Chen XY1, Li LB2, Yu XT3, Zhou Y1, Yang WJ1, Liu Z1, Zhao N1, Fu C1, Zhang SH4, Chen YF5.
- Acupuncture in medicine : journal of the British Medical Acupuncture Society.Acupunct Med.2015 May 15. pii: acupmed-2014-010732. doi: 10.1136/acupmed-2014-010732. [Epub ahead of print]
- OBJECTIVE: Imbalance between T-helper 17 (Th17) cells and regulatory T (Treg) cells is causally linked to the development of rheumatoid arthritis (RA). In this study, we tested the hypothesis that electroacupuncture (EA) confers therapeutic benefits in RA through activation of vasoactive intestinal
- PMID 25979865
Japanese Journal
- Effects of Vasoactive Intestinal Polypeptide and Forskolin on Mrna Expression of Prolactin and Prolactin Regulatory Element-Binding Protein in the Anterior Pituitary Gland of Chicken Embryo and Laying Hens
- VIP-Lipopeptide修飾リポソームによる新規ドラッグデリバリーシステム
- 産卵率にもとづいて選抜された烏骨鶏選抜第5世代における生産形質と2番染色体上の候補遺伝子との関連性について
Related Links
- Vasoactive Intestinal Peptide (VIP) 1 Receptor THREE NONADJACENT AMINO ACIDS ARE RESPONSIBLE FOR SPECIES SELECTIVITY WITH RESPECT TO RECOGNITION OF ... Alain Couvineau ‡, Christiane ...
- This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung ...
★リンクテーブル★
[★]
- 関
- vasoactive intestinal peptide receptor
[★]
- 英
- vasoactive intestinal peptide receptor、VIP receptor
- 関
- 血管作用性小腸ペプチドレセプター、VIPレセプター、VIP受容体
[★]
- 英
- vasoactive intestinal peptide receptor、VIP receptor
- 関
- 血管作用性小腸ペプチド受容体、VIPレセプター、VIP受容体
[★]
- 関
- type I vasoactive intestinal polypeptide receptor、VIP-1 receptor
[★]
- 関
- VIP-2 receptor、VPAC2 receptor
[★]
- 関
- alimentary system、bowel、digestive system、enteric、enteric canal、entero、gastrointestinal、gastrointestinal system、GI、gut、intestinal tract、intestine
[★]
- 関
- peptide hormone receptor
[★]