WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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A recombinant slow-release PACAP-derived peptide alleviates diabetes by promoting both insulin secretion and actions.

Ma Y1, Fang S1, Zhao S1, Wang X1, Wang D1, Ma M2, Luo T1, Hong A3.
Biomaterials.Biomaterials.2015 May;51:80-90. doi: 10.1016/j.biomaterials.2015.01.064. Epub 2015 Feb 17.
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuroendocrine factor that activates both the receptor VPAC1 and VPAC2. Although PACAP possesses insulinotropic activity, its therapeutic application is limited by the extremely short acting half-life and the stimulatory effects on gluc
PMID 25771000

Telegdy G1, Adamik A2.
Behavioural brain research.Behav Brain Res.2015 Mar 15;281:333-8. doi: 10.1016/j.bbr.2014.12.039. Epub 2014 Dec 25.
The action of PACAP-38 was studied by measuring the anxiogenic-anxiolytic behavior of rats in an elevated plus maze. PACAP-38 was administered into the lateral brain ventricle and the behavior of the animals was measured 3h later. The possible involvement of transmitters was measured by pretreating
PMID 25543171

VPAC2 receptor expression in human normal and neoplastic tissues: evaluation of the novel MAB SP235.

Schulz S1, Mann A2, Novakhov B2, Piggins HD2, Lupp A2.
Endocrine connections.Endocr Connect.2015 Mar;4(1):18-26. doi: 10.1530/EC-14-0051. Epub 2014 Dec 11.
The vasoactive intestinal peptide receptor 2 (VPAC2) is widely distributed throughout the body and is also overexpressed in a variety of human neoplastic tissues. However, little is known about its precise tissue distribution, regulation and function, which is in part be due to the lack of specific
PMID 25504760

<b>Role of pituitary adenylyl cyclase-activating polypeptide in intracellular calcium dynamics of neurons and satellite cells in rat superior cervical </b><b>ganglia </b>