WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
a fibrous band of scar tissue that binds together normally separate anatomical structures
abnormal union of bodily tissues; most common in the abdomen
of or relating to or having vessels that conduct and circulate fluids; "vascular constriction"; "a vascular bundle"
(physics and chemistry) the simplest structural unit of an element or compound

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
粘着,付着
(血液・樹液などを運ぶ)管の,導管の,血管の
分子《略》『mol』) / (一般に)(…の)微量《+『of』+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/15 23:23:12」(JST)

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Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene.^[1] VCAM-1 functions as a cell adhesion molecule.

Structure

The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. It is alternatively spliced into two known RNA transcripts that encode different isoforms in humans.^[2] The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily.

Function

The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.

Upregulation of VCAM-1 in endothelial cells by cytokines occurs as a result of increased gene transcription (e.g., in response to Tumor necrosis factor-alpha (TNF-α) and Interleukin-1 (IL-1)) and through stabilization of Messenger RNA (mRNA) (e.g., Interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem NF-κB (nuclear factor-kappa B) sites. The sustained expression of VCAM-1 lasts over 24 hours.

Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. VCAM-1 expression has also been observed in other cell types (e.g., smooth muscle cells). It has also been shown to interact with EZR^[3] and Moesin.^[3]

Pharmacology

Certain melanoma cells can use VCAM-1 to adhere to the endothelium, and VCAM-1 may participate in monocyte recruitment to atherosclerotic sites. As a result, VCAM-1 is a potential drug target.

References

^ Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T (1991). "The human VCAM1 gene is assigned to chromosome 1p31-p32". Cytogenet. Cell Genet. 58: 1852. doi:10.1159/000133735.
^ "Entrez Gene: VCAM1 vascular cell adhesion molecule 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7412.
^ ^a ^b Barreiro, Olga; Yanez-Mo Maria, Serrador Juan M, Montoya Maria C, Vicente-Manzanares Miguel, Tejedor Reyes, Furthmayr Heinz, Sanchez-Madrid Francisco (Jun. 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes". J. Cell Biol. (United States) 157 (7): 1233–45. doi:10.1083/jcb.200112126. ISSN 0021-9525. PMC 2173557. PMID 12082081. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2173557/.

External links

VCAM-1 at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
2. 内皮：プライマー the endothelium a primer
3. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
4. 鎌状細胞貧血における臨床的ばらつき clinical variability in sickle cell anemia
5. アテローム性動脈硬化症の病因 pathogenesis of atherosclerosis

English Journal

Resveratrol inhibits Staphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells.

Lee IT1, Lin CC2, Hsu CK1, Wu MY1, Cho RL1, Yang CM1.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Sep 1;127(6):375-90. doi: 10.1042/CS20130816.
Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted to intensive-care units, causing septicaemia or pneumonia. S. aureus is considered to play an important role in the induction of cell adhesion molecules. Resveratrol, a compound found in the skins of red fr
PMID 24617573

VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression.

Leus NG1, Morselt HW1, Zwiers PJ1, Kowalski PS1, Ruiters MH2, Molema G1, Kamps JA3.
International journal of pharmaceutics.Int J Pharm.2014 Jul 20;469(1):121-31. doi: 10.1016/j.ijpharm.2014.04.041. Epub 2014 Apr 18.
In recent years much research in RNA nanotechnology has been directed to develop an efficient and clinically suitable delivery system for short interfering RNA (siRNA). The current study describes the in vivo siRNA delivery using PEGylated antibody-targeted SAINT-based-lipoplexes (referred to as ant
PMID 24746643

Parathyroid hormone-related protein (107-111) improves the bone regeneration potential of gelatin-glutaraldehyde biopolymer-coated hydroxyapatite.

Lozano D1, Sánchez-Salcedo S2, Portal-Núñez S3, Vila M2, López-Herradón A3, Ardura JA3, Mulero F4, Gómez-Barrena E5, Vallet-Regí M6, Esbrit P3.
Acta biomaterialia.Acta Biomater.2014 Jul;10(7):3307-16. doi: 10.1016/j.actbio.2014.03.025. Epub 2014 Apr 2.
Biopolymer-coated nanocrystalline hydroxyapatite (HA) made as macroporous foams which are degradable and flexible are promising candidates as orthopaedic implants. The C-terminal (107-111) epitope of parathyroid hormone-related protein (PTHrP) exhibits osteogenic properties. The main aim of this stu
PMID 24704694

Japanese Journal

Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation

Yoshihara Takuma,Shimada Kazunori,Fukao Kosuke,Sai Eiryu,Sato-Okabayashi Yayoi,Matsumori Rie,Shiozawa Tomoyuki,Alshahi Hamad,Miyazaki Tetsuro,Tada Norihiro,Daida Hiroyuki
Circulation Journal 79(7), 1470-1478, 2015
… EPA administration and DHA administration significantly decreased the expression of tumor necrosis factor-α, monocyte chemoattractant protein-1, transforming growth factor-β, matrix metalloproteinases (MMP)-2, MMP-9, and vascular cell adhesion molecule-1 in the aortas. …
NAID 130005083946

Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation

Yoshihara Takuma,Shimada Kazunori,Fukao Kosuke,Sai Eiryu,Sato-Okabayashi Yayoi,Matsumori Rie,Shiozawa Tomoyuki,Alshahi Hamad,Miyazaki Tetsuro,Tada Norihiro,Daida Hiroyuki
Circulation Journal advpub(0), 2015
… EPA administration and DHA administration significantly decreased the expression of tumor necrosis factor-α, monocyte chemoattractant protein-1, transforming growth factor-β, matrix metalloproteinases (MMP)-2, MMP-9, and vascular cell adhesion molecule-1 in the aortas. …
NAID 130005068466

4 VCAM-1はRANKLが誘導する破骨細胞分化を増強する(第543回大阪歯科学会例会)

林寛,氏井庸介,合田征司,松本尚之
歯科医学 77(2), 96, 2014-09-25
… Vascular cell adhesion molecule-1 (VCAM-1) is bound to very late antigen-4 (VLA-4) which is a kind of α4 β1-integrin. … We focused on how VCAM-1/α4 integrin mediates the differentiation into osteoclasts and found that it was through FAK. … These findings confirmed that VCAM-1 regulates the differentiation of bone into osteoclasts. …
NAID 110009857559

Related Pictures

★リンクテーブル★

リンク元	「血管細胞接着分子-1」
関連記事	「vascular」「adhesion」「molecule」「cell」

「血管細胞接着分子-1」

Vascular cell adhesion molecule 1
	; PDB rendering based on 1ij9.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1IJ9, 1VCA, 1VSC
Identifiers
Symbols	VCAM1; CD106; INCAM-100
External IDs	OMIM: 192225 MGI: 98926 HomoloGene: 838 ChEMBL: 3735 GeneCards: VCAM1 Gene
Gene Ontology
Molecular function	• integrin binding; • cell adhesion molecule binding;
Cellular component	• podosome; • extracellular space; • plasma membrane; • microvillus; • external side of plasma membrane; • cell surface; • integral to membrane; • filopodium; • sarcolemma; • apical part of cell; • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex;
Biological process	• response to hypoxia; • acute inflammatory response; • chronic inflammatory response; • cell adhesion; • heterophilic cell-cell adhesion; • leukocyte cell-cell adhesion; • heart development; • aging; • response to nutrient; • response to ionizing radiation; • virus-host interaction; • cytokine-mediated signaling pathway; • membrane to membrane docking; • B cell differentiation; • positive regulation of T cell proliferation; • regulation of immune response; • leukocyte tethering or rolling; • interferon-gamma-mediated signaling pathway; • chorio-allantoic fusion; • cellular response to glucose stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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