出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/10 16:34:29」(JST)
| tryptophan-tRNA ligase | |||||||||
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| Identifiers | |||||||||
| EC number | 6.1.1.2 | ||||||||
| CAS number | 9023-44-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a tryptophan-tRNA ligase (EC 6.1.1.2) is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are ATP, L-tryptophan, and tRNA(Trp), whereas its 3 products are AMP, diphosphate, and L-tryptophyl-tRNATrp.
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tryptophan:tRNATrp ligase (AMP-forming). Other names in common use include tryptophanyl-tRNA synthetase, L-tryptophan-tRNATrp ligase (AMP-forming), tryptophanyl-transfer ribonucleate synthetase, tryptophanyl-transfer ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA synthase, tryptophan translase, and TrpRS. This enzyme participates in tryptophan metabolism and aminoacyl-trna biosynthesis.
As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes 1D2R, 1I6K, 1I6L, 1I6M, 1M83, 1MAU, 1MAW, 1MB2, 1O5T, 1R6T, 1R6U, 1ULH, 1YIA, 1YID, 2A4M, 2AKE, 2AZX, 2DR2, 2G36, 2IP1, and 2OV4.
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| リンク元 | 「tryptophanyl-tRNA synthetase」「トリプトファンtRNAリガーゼ」 |
| 関連記事 | 「tRNA」「ligase」「tRNAs」「tryptophan」「tRNA ligase」 |
トリプトファニルtRNA合成酵素、トリプトファニルtRNAシンテターゼ
[★] トランスファーRNA, transfer RNA, 転位RNA