tryptophanyl-tRNA synthetase

トリプトファニルtRNA合成酵素、トリプトファニルtRNAシンテターゼ

関

tryptophan-tRNA ligase

WordNet

1. an amino acid that occurs in proteins; is essential for growth and normal metabolism; a precursor of niacin (同)tryptophane

UpToDate Contents

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• 1. 成人における皮膚筋炎および多発性筋炎の臨床症状 clinical manifestations of dermatomyositis and polymyositis in adults
• 2. 成人における皮膚筋炎および多発性筋炎の初期治療 initial treatment of dermatomyositis and polymyositis in adults
• 3. ヘキソースリン酸側路およびグルタチオン代謝関連疾患 related disorders of the hexose monophosphate shunt and glutathione metabolism
• 4. 炎症性ミオパチーの病因 pathogenesis of inflammatory myopathies
• 5. 皮膚筋炎および多発性筋炎における間質性肺疾患：臨床症状および診断 interstitial lung disease in dermatomyositis and polymyositis clinical manifestations and diagnosis

English Journal

• Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness.

• Lee CW1, Chang KP2, Chen YY3, Liang Y3, Hsueh C4,3,5, Yu JS1,6,3, Chang YS1,3, Yu CJ1,6,3.
• Oncotarget.Oncotarget.2015 Jun 17. [Epub ahead of print]
• Oral squamous cell carcinoma (OSCC) is one of the most common neoplasms worldwide. Previously, we identified the angiostatic agent tryptophanyl-tRNA synthetase (TrpRS) as a dysregulated protein in OSCC based on a proteomics approach. Herein, we show that TrpRS is overexpressed in OSCC tissues (139/1
• PMID 26110569

• Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression.

• Noh KT1, Cho J2, Chun SH3, Jang JH4, Cha GS3, Jung ID3, Jang DD1, Park YM3.
• BMB reports.BMB Rep.2015 May;48(5):283-8.
• We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow- derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol
• PMID 25248565

• In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.

• Du YL1, Alkhalaf LM1, Ryan KS2.
• Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Mar 3;112(9):2717-22. doi: 10.1073/pnas.1419964112. Epub 2015 Feb 17.
• The bacterial tryptophanyl-tRNA synthetase inhibitor indolmycin features a unique oxazolinone heterocycle whose biogenetic origins have remained obscure for over 50 years. Here we identify and characterize the indolmycin biosynthetic pathway, using systematic in vivo gene inactivation, in vitro bioc
• PMID 25730866

Japanese Journal

• Molecular Recognition of Tryptophan tRNA by Tryptophanyl-tRNA Synthetase from Aeropyrum pernix K1

• Tsuchiya Wataru,Hasegawa Tsunemi
• The journal of biochemistry 145(5), 635-641, 2009-05-01
• NAID 10025589010

• 13 超好熱古細菌Aeropyrum pernix K1由来トリプトファニル-tRNA合成酵素によるtRNA認識と進化(一般講演,第34回学術講演会講演要旨集)

• 土屋 渉,長谷川 典巳
• Viva origino 37(Supplement), 19, 2009-03-01
• NAID 110007160797

• 24 tRNAアイデンティティーからみた古細菌由来トリプトファニル-tRNA合成酵素の分子進化(一般講演,第31回学術講演会講演要旨集)

• 土屋 渉,久野 敦,長谷川 典巳
• Viva origino 34(1), 31, 2006-03-10
• NAID 110005853617

Related Links

• WARS (gene) - Wikipedia, the free encyclopedia

Tryptophanyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the WARS gene. ... Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon.

• WARS tryptophanyl-tRNA synthetase [Homo sapiens (human)]

19 Mar 2013 ... Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are ...

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★リンクテーブル★

リンク元	「トリプトファニルtRNA合成酵素」「トリプトファニルtRNAシンテターゼ」「tryptophan-tRNA ligase」
関連記事	「synthetase」「tRNA」「tRNAs」「tryptophan」

「トリプトファニルtRNA合成酵素」

　　[★]

英

tryptophanyl-tRNA synthetase

関

トリプトファンtRNAリガーゼ、トリプトファニルtRNAシンテターゼ

「トリプトファニルtRNAシンテターゼ」

　　[★]

英

tryptophanyl-tRNA synthetase

関

トリプトファニルtRNA合成酵素

「tryptophan-tRNA ligase」

　　[★]

トリプトファンtRNAリガーゼ

関

tryptophanyl-tRNA synthetase

「synthetase」

　　[★]

• n.

• (ATPやNADを必要とする2分子連結酵素リガーゼの別名)シンテターゼ、シンセターゼ、連結酵素、合成酵素

関

ligase、synthase

「tRNA」

　　[★] トランスファーRNA, transfer RNA, 転位RNA

「tRNAs」

　　[★] トランスファーRNA transfer RNAs

「tryptophan」

　　[★] トリプトファン Trp W