WordNet

a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation

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Discovery of a novel trimebutine metabolite and its impact on N-desmethyltrimebutine quantification by LC-MS/MS.

Montpetit H1, Ranger M, Colin P, Furtado M, Garofolo F.
Bioanalysis.Bioanalysis.2015;7(8):1007-15. doi: 10.4155/bio.15.31.
BACKGROUND: A failure in incurred sample reanalysis (ISR) for N-desmethyltrimebutine (NDMT), during the analysis of a trimebutine-containing drug GIC-1001 Phase I study, led to the discovery of a never-before reported metabolite of trimebutine.RESULTS: A positive bias for NDMT during the ISR and pos
PMID 25966011

Safety, tolerability and pharmacokinetics of trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) in a randomized phase I integrated design study: single and multiple ascending doses and effect of food in healthy volunteers.

Paquette JM1, Rufiange M1, Iovu Niculita M1, Massicotte J1, Lefebvre M1, Colin P2, Telmat A2, Ranger M3.
Clinical therapeutics.Clin Ther.2014 Nov 1;36(11):1650-64. doi: 10.1016/j.clinthera.2014.08.005. Epub 2014 Sep 15.
PURPOSE: Trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) is a new drug intended to be used for the management of visceral pain in patients undergoing sedation-free, full colonoscopy. The objectives of this Phase I, single-center, randomized, double-blinded, placebo-controlled, integrated stud
PMID 25224876

Controversial effect on Erk activation of some cytotoxic drugs in human LOVO colon cancer cells.

Jemel-Oualha I1, Elloumi-Mseddi J, Beji A, Hakim B, Aifa S.
Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2014 Oct 24:1-5. [Epub ahead of print]
Abstract The use of some classic antibiotics was recently shown to inhibit growth and to induce apoptosis in human LOVO colon cancer cells. In this study, we describe that ciprofloxacin (CI), trimebutine maleate (COL) and tiemonium methylsulfate (VIS) greatly inhibit cell proliferation in vitro. Pro
PMID 25343691

Lee Suh-Young,Kim Mi-Yeong,Kang Sung-Yoon,Song Woo-Jung,Kang Hye-Ryun
Allergology International 60(4), 555-556, 2011
… Trimebutine maleate [2-dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoic acid] has been demonstrated to be active for relieving abdominal pain and it is widely used for patients with irritable bowel syndrome. … To our knowledge, only two cases of trimebutine induced hypersensitivity have been reported, and both were delayed type reactions. … Here, we report the first case of trimebutine maleate-induced anaphylaxis. …
NAID 130004477120

土井田誠,加藤恵三,米本和弘,牧田浩樹,畠山大二郎,楠幸博,宮本謙,藤塚秀樹,山下知巳,石丸純一,柴田敏之
日本口腔科学会雑誌 55(4), 246-252, 2006
… and Group C, which received the same dosage of CHH as Group B, except for the addition of 100mg of trimebutine maleate, twice daily for seven weeks (n=21).<BR>The three groups showed similar significant improvements in both salivary flow rate (p<0.01) and subjective symptoms of dryness of the mouth (p<0.01). …
NAID 130004335948

Novelty Stress Increases Fecal Pellet Output in Mongolian Gerbils : Effects of Several Drugs

Okano Shiho,Nagaya Hideaki,Inatomi Nobuhiro
Journal of pharmacological sciences 98(4), 411-418, 2005-08-20
… Drugs reportedly effective for stress-induced defecation, like alosetron hydrochloride, atropine sulfate, and trimebutine maleate, inhibited both the novelty stress-induced increase in fecal pellet output and spontaneous defecation. …
NAID 10025729637