WordNet

resulting from or employing derivation; "a derivative process"; "a highly derivative prose style"
a compound obtained from, or regarded as derived from, another compound
(linguistics) a word that is derived from another word; "`electricity is a derivative of `electric"
any of a group of drugs commonly used as diuretics in the treatment of hypertension; they block the reabsorption of sodium in the kidneys

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The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.

Sabatini S1, Manfroni G1, Barreca ML1, Bauer SM2, Gargaro M3, Cannalire R1, Astolfi A1, Brea J4, Vacca C3, Pirro M5, Massari S1, Tabarrini O1, Loza MI4, Fallarino F3, Laufer SA2, Cecchetti V1.
Chemical biology & drug design.Chem Biol Drug Des.2015 Oct;86(4):531-45. doi: 10.1111/cbdd.12516. Epub 2015 Feb 19.
The identification, synthesis, biological activity, and binding mode prediction of a series of pyrazolobenzothiazines as novel p38α MAPK inhibitors are reported. Some of these compounds showed interesting activity in both p38α MAPK and TNF-α release assays. Derivative 6 emerged as the most intere
PMID 25589097

Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds.

Okazaki S1, Oishi S, Mizuhara T, Shimura K, Murayama H, Ohno H, Matsuoka M, Fujii N.
Organic & biomolecular chemistry.Org Biomol Chem.2015 Apr 28;13(16):4706-13. doi: 10.1039/c5ob00301f.
3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182) and 3,4-dihydro-2H-benzo[4,5]isothiazolo[2,3-a]pyrimidine are the heterocyclic antiretroviral agents against human immunodeficiency virus type 1 (HIV-1) infection. On the basis of similar structure-activity relationships of anti-
PMID 25800792

Novel spectrophotometric methods for simultaneous determination of Amlodipine, Valsartan and Hydrochlorothiazide in their ternary mixture.

Lotfy HM1, Hegazy MA1, Mowaka S2, Mohamed EH3.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2015 Apr 5;140:495-508. doi: 10.1016/j.saa.2014.12.096. Epub 2015 Jan 5.
This work represents a comparative study of two smart spectrophotometric techniques namely; successive resolution and progressive resolution for the simultaneous determination of ternary mixtures of Amlodipine (AML), Hydrochlorothiazide (HCT) and Valsartan (VAL) without prior separation steps. These
PMID 25638433

Renin-Angiotemsin-Aldosterone系に関する研究 : Na制限及び体位変換におけるPlasma Renin ActivityとAldosterone排泄量の変動に就て

窪田欣一郎
日本循環器学誌 33(3), 323-332, 1969-06-20
… A sample of peripheral venous blood was obtained in the morning after overnight recumbency and after two to four hours of upright position plus thiazide administratoin (Fig. 1). … PRA was measured by BOUCHER'S method and urinary aldosterone was determined by blue tetrazolium coloration (or double isotope derivative method) utilizing our new systems of thin layer chromatography instead of paper chromatography because of the economy of time and cost without the sacrifice of accuracy (Fig.2,3). …
NAID 110002603419