temefos

テメフォス

関

abate

WordNet

1. become less in amount or intensity; "The storm abated"; "The rain let up after a few hours" (同)let up, slack off, slack, die away

PrepTutorEJDIC

1. …‘の'勢いを減らす,軽減する / (法律で)〈妨害など〉'を'排除する;〈効力など〉'を'停止する / 減る,やわらぐ,弱まる

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/10/28 20:52:59」(JST)

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Temefos

Names
IUPAC name O,O,O′,O′-Tetramethyl O,O′-sulfanediylbis(1,4-phenylene) diphosphorothioate
Other names [4-(4-dimethoxyphosphinothioyloxyphenyl)sulfanylphenoxy]- dimethoxy-sulfanylidene-phosphorane
Identifiers
CAS Number	3383-96-8 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:38954 Y
ChemSpider	5199 Y
ECHA InfoCard	100.020.175
KEGG	D06062 Y
MeSH	Temefos
PubChem CID	5392
UNII	ONP3ME32DL Y
InChI InChI=1S/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3 Y Key: WWJZWCUNLNYYAU-UHFFFAOYSA-N Y InChI=1/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3 Key: WWJZWCUNLNYYAU-UHFFFAOYAC
SMILES S=P(OC)(OC)Oc2ccc(Sc1ccc(OP(=S)(OC)OC)cc1)cc2
Properties
Chemical formula	C16H20O6P2S3
Molar mass	466.46 g·mol−1
Appearance	white, crystalline solid
Density	1.32 g cm−3
Melting point	30 °C (86 °F; 303 K)
Boiling point	120–125 °C (248–257 °F; 393–398 K) (decomposes)
Solubility in water	insoluble
Vapor pressure	0.00000007 mmHg (20°C)
Hazards
US health exposure limits (NIOSH):
PEL (Permissible)	15 mg/m3
REL (Recommended)	TWA 10 mg/m3 (total) TWA 5 mg/m3 (resp)
IDLH (Immediate danger)	N.D.
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Temefos or temephos (trade name Abate) is an organophosphate larvicide used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae.

As with other organophosphates, temephos affects the central nervous system through inhibition of cholinesterase. In larvae, this results in death before reaching the adult stage.

In the developing world where the vector-borne disease dengue fever is endemic, temephos is widely used and applied by both private and public pest control in areas of standing water where the Aedes aegypti mosquito breeds in order to reduce the population of this disease-carrying insect. Temephos is also used in the Guinea worm eradication program to kill water fleas that carry guinea worm larvae.

Resistance to temephos by A. aegypti has been seen in Brazil. The Brazilian Aedes aegypti resistance monitoring program detected temephos resistance in A. aegypti populations from several localities in the country in 1999 (Funasa 2000, Lima et al. 2003). In 1999, mosquitoes from the city of Rio de Janeiro were already resistant to temephos.

External links

• NIOSH Pocket Guide to Chemical Hazards
• International Chemical Safety Cards
• Official product site
• Temefos in the Pesticide Properties DataBase (PPDB)

Bibliography

• Dejous C & Elouard J.M (1977) Action de l'abate sur les invertébérs aquatiques ; cinétique de décrochement à court et moyen terme (in French).

English Journal

• Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis.

• Sandeep C1, Venugopala KN2, Gleiser RM3, Chetram A4, Padmashali B5,6, Kulkarni RS7, Venugopala R8, Odhav B4.
• Chemical biology & drug design.Chem Biol Drug Des.2016 Dec;88(6):899-904. doi: 10.1111/cbdd.12823. Epub 2016 Sep 9.
• Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron-deficient alkynes in the presence of water as the base and solvent at 80 °C. Yield of the title compounds was good and reactions performed were eco-frien
• PMID 27440719

• How heterogeneous is the involvement of ABC transporters against insecticides?

• Porretta D1, Epis S2, Mastrantonio V3, Ferrari M4, Bellini R5, Favia G6, Urbanelli S7.
• Acta tropica.Acta Trop.2016 May;157:131-5. doi: 10.1016/j.actatropica.2016.02.002. Epub 2016 Feb 6.
• Understanding the molecular mechanisms underlying cellular defense against xenobiotic compounds is a main research issue in medical and veterinary entomology, as insecticide/acaricide resistance is a major threat in the control of arthropods. ABC transporters are recognized as a component of the det
• PMID 26855383

• Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti.

• Paiva MH1, Lovin DD2, Mori A3, Melo-Santos MA4, Severson DW5, Ayres CF6.
• Genomics.Genomics.2016 Jan;107(1):40-8. doi: 10.1016/j.ygeno.2015.11.004. Epub 2015 Nov 11.
• Organophosphate insecticides (OP) have extensively been used to control mosquitoes, such as the vector Aedes aegypti. Unfortunately, OP resistance has hampered control programs worldwide. We used Quantitative Trait Locus (QTL) mapping to evaluate temephos resistance in two F1 intercross populations
• PMID 26576515

Japanese Journal

• オオチョウバエ終齢幼虫に対する7種薬剤の基礎効力試験

• 家屋害虫 26(2), 119-122, 2004-12-15
• NAID 110007724244

• 1993-1994 年の沖縄県における Anopheles minimus, An. saperoi および An. sinensis 幼虫の殺虫剤感受性について

• 衞生動物 49(3), 227-230, 1998-09-15
• NAID 110003818846

• 1970-1972 年および 1989 年の沖縄県におけるコガタアカイエカ Culex tritaeniorhynchus 幼虫の殺虫剤抵抗性について

• 衞生動物 44(3), 263-269, 1993-09-15
• NAID 110003818250

Related Pictures

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★リンクテーブル★

リンク元

「abate」

「abate」

　　[★]

• vt.

• 減ずる。(値を)下げる、ひく、(税を)減額する。(勢い・苦痛などを)和らげる、弱める

• vi.

• 減ずる。(勢い・激しさが)衰える、和らぐ、(洪水・熱が)ひく、(あらしが)なぐ

関

abatement、alleviate、alleviation、ameliorate、amelioration、mitigate、mitigation、palliate、palliation、relief、relieve、remission、remit、temefos