subepidermal blistering disease

表皮下水疱症

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• 1. 水疱型エリテマトーデスbullous systemic lupus erythematosus [show details]
  …vesicles and/or bullae on normal-appearing or erythematous skin; Histopathologic finding of subepidermal blistering and a neutrophil-predominant infiltrate in the superficial dermis; Direct immunofluorescence …
• 2. 線状IgA水疱性皮膚症linear iga bullous dermatosis [show details]
  …bullous dermatosis are nonspecific and often closely resemble dermatitis herpetiformis. A subepidermal blister with an underlying neutrophil-predominant dermal infiltrate is characteristic . Lymphocytes …
• 3. 偽ポルフィリン症pseudoporphyria [show details]
  …dorsum of the hands and other sun-exposed areas. Histologically, there is a noninflammatory subepidermal blister. This topic will discuss the pathogenesis, clinical manifestations, diagnosis, and treatment …
• 4. 水疱性類天疱瘡および粘膜類天疱瘡の臨床的特徴および診断clinical features and diagnosis of bullous pemphigoid and mucous membrane pemphigoid [show details]
  …of bullous pemphigoid include : Eosinophilic spongiosis (particularly in early lesions) Subepidermal blister formation (often with numerous eosinophils within cleft) A superficial dermal inflammatory …
• 5. 皮膚の水疱を有する患者に対するアプローチapproach to the patient with cutaneous blisters [show details]
  …characteristic of intraepidermal or suprabasilar blisters. Lastly, tense bullae are typically seen in subepidermal blistering disorders due to the relatively greater proportion of epidermis overlying the blister cavity …

English Journal

• Dipeptidyl peptidase IV inhibitor-associated bullous pemphigoid: a recently recognized autoimmune blistering disease with unique clinical, immunological and genetic characteristics.

• , N N, W W, W W, .
• Immunological medicine. 2019 Jun;()1-7.
• Bullous pemphigoid (BP) is an organ-specific autoantibody-mediated autoimmune blistering skin disorder that tends to affect the elderly. Tense blister formation associated with itchy urticarial erythema is clinically observed in BP, and subepidermal blister formation with eosinophilic infiltration i
• PMID 31169082

• Case of autoimmune intraepidermal and subepidermal blistering disease in which autoantibodies to desmoglein 1 and BP230 coexist.

• Sugai T, Ujiie H, Nakamura H, Kikuchi K, Iwata H, Shimizu H.
• The Journal of dermatology. 2019 Jun;46(6)e215-e216.
• PMID 30549100

• Current Clinical Trials in Pemphigus and Pemphigoid.

• Izumi K, Bieber K, Ludwig RJ.
• Frontiers in immunology. 2019 ;10()978.
• Autoimmune bullous dermatoses (AIBDs) are a group of rare chronic inflammatory skin diseases, which clinically manifest as blisters and erosions of the skin and/or mucosa. Immunologically, AIBDs are characterized and caused by autoantibodies targeting adhesion molecules in the skin and mucosa. Accor
• PMID 31130959

Japanese Journal

• 線状皮膚炎様臨床像を呈し顆粒状C3皮膚症と診断した表皮下水疱症の1例

• 濱本 千晶,古川 福実,神人 正寿,有本 けい子,石井 文人,橋本 隆,鶴田 大輔,金澤 伸雄
• 日本皮膚科学会雑誌 129(4), 537-542, 2019
• <p>71歳男．3年程前から両腰と膝周囲に痒みを伴う線状皮疹が出没し，湿疹としてステロイド外用加療も軽快せず半年前からは水疱も伴った．臨床像は線状皮膚炎様，病理像は好酸球とリンパ球浸潤を伴う表皮下水疱．血中抗BP180NC16a抗体陰性．蛍光抗体直接法では基底膜にC3の顆粒状・線状沈着を認めたが，IgG，IgAは陰性．蛍光抗体間接法では正常ヒト皮膚はIgG，IgAともに陰性．1M食塩水 …
• NAID 130007635402

• Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients

• Iwata Hiroaki,Vorobyev Artem,Koga Hiroshi,Recke Andreas,Zillikens Detlef,Prost-Squarcioni Catherine,Ishii Norito,Hashimoto Takashi,Ludwig Ralf J.
• Orphanet Journal of Rare Diseases 13, 153, 2018-09-04
• … Background: Epidermolysis bullosa acquisita (EBA) is an orphan autoimmune disease. … Several clinical phenotypes have been described, but subepidermal blistering is characteristic of all variants. …
• NAID 120006533146

• Complement-independent blistering mechanisms in bullous pemphigoid

• Iwata Hiroaki,Ujiie Hideyuki
• Experimental dermatology 26(12), 1235-1239, 2017-12
• … Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that clinically demonstrates tense blisters with widespread erythema, histologically demonstrates subepidermal blistering and immunologically demonstrates the presence of circulating autoantibodies against hemidesmosomal molecules. …
• NAID 120006540055

Related Links

• Blistering Diseases - Cleveland Clinic Center for Continuing ...

Autoimmune mucocutaneous blistering diseases (AMBDs) are a group of conditions that manifest with blisters on the skin or mucous membranes. In order to get the most accurate diagnosis when performing biopsies in AMBD, the ...

• b. Diseases with subepidermal blistering (pemphigoid group)

In bullous pemphigoid, subepidermal blistering is accompa-nied by eosinophilic infiltration (Fig. 14.29). Linear IgG and C3 deposition in the basement membranes of the lesions is observed by direct immunofluorescence (IF) (Fig. 14.30).

• Blistering skin diseases | DermNet NZ

Dermatological emergencies. Blistering skin diseases. Authoritative facts about the skin from DermNet New Zealand. DermNet NZ RANDOM RANDOM TRANSLATE TRANSLATE ...

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★リンクテーブル★

リンク元	「表皮下水疱症」
関連記事	「disease」「blistering」

「表皮下水疱症」

　　[★]

英

subepidermal blistering disease subepidermal blistering disorder

関

類天疱瘡、水疱症

• 水疱性類天疱瘡
• 妊娠性疱疹
• 瘢痕性類天疱
• 後天性表皮水疱症
• Duhring疱疹状皮膚炎
• 線状IgA水疱症

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「blistering」

　　[★]

• adj.

• 水ぶくれを起こさせる。痛烈な、猛烈な

• adv.
• n.

関

blister = bulla 水疱