strychnine

ストリキニーネ    

WordNet

  1. an alkaloid plant toxin extracted chiefly from nux vomica; formerly used as a stimulant

PrepTutorEJDIC

  1. ストリキニーネ(有毒の結晶で中枢神経の興奮剤)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/27 12:13:32」(JST)

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English Journal

  • Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: A natural product coupled approach to semicarbazones for antiepileptic activity.
  • Rajak H, Singh Thakur B, Singh A, Raghuvanshi K, Sah AK, Veerasamy R, Sharma PC, Singh Pawar R, Kharya MD.SourceMedicinal Chemistry Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur 495 009, CG, India. Electronic address: harishdops@yahoo.co.in.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2013 Feb 1;23(3):864-8. doi: 10.1016/j.bmcl.2012.11.051. Epub 2012 Nov 27.
  • Two novel series of N(4)-(5-(2/3/4-substituted-phenyl)-1,3,4-oxadiazol-2-yl)-N(1)-(2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enylidene)semicarbazide and N(4)-(5-(2/3/4-substituted-phenyl)-1,3,4-oxadiazol-2-yl)-N(1)-(3,7-dimethylocta-3,6-dienylidene)-semicarbazide were synthesized to meet structural prer
  • PMID 23265873
  • Spontaneous glycine-induced calcium transients in spinal cord progenitors promote neurogenesis.
  • Brustein E, Côté S, Ghislain J, Drapeau P.SourceDepartment of Pathology and Cell Biology and "Groupe de recherche sur le système nerveux central," University of Montreal, Montreal, Quebec H3C 3J7, Canada.
  • Developmental neurobiology.Dev Neurobiol.2013 Feb;73(2):168-75. doi: 10.1002/dneu.22050. Epub 2012 Oct 17.
  • Glycine and GABA are depolarizing during early development, but the purpose of this paradoxical chloride-mediated depolarization remains unclear, especially at early stages. It was previously reported that suppressing glycine signaling from the beginning of development in zebrafish embryos caused an
  • PMID 22888055
  • Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-Type GABA receptors.
  • Huang C, Li WG, Zhang XB, Wang L, Xu TL, Wu D, Li Y.SourceInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China; Neuroscience Division, Department of Biochemistry and Molecular Cell Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
  • Neuropharmacology.Neuropharmacology.2013 Feb;65:1-11. doi: 10.1016/j.neuropharm.2012.09.001. Epub 2012 Sep 10.
  • Alpha (α)-asarone is a major effective compound isolated from the Chinese medicinal herb Acorus gramineus, which is widely used in clinical practice as an antiepileptic drug; however, its mechanism of action remains unclear. In this study, we have characterized the action of α-asarone on the excit
  • PMID 22975146

Japanese Journal

  • Orexin neurons receive glycinergic innervations
  • Hondo Mari,Furutani Naoki,Yamasaki Miwako,Watanabe Masahiko,Sakurai Takeshi
  • PLoS ONE 6(9), e25076, 2011-09-16
  • … These responses were inhibited by a specific glycine receptor antagonist, strychnine. …
  • NAID 120003497597
  • HPLC Determination of Strychnine and Brucine in Rat Tissues and the Distribution Study of Processed Semen Strychni
  • CHEN Jun,HOU Ting,FANG Yun,CHEN Zhi-peng,LIU Xiao,CAI Hao,LU Tu-lin,YAN Guo-jun,CAI Bao-chang
  • YAKUGAKU ZASSHI 131(5), 721-729, 2011
  • …   A simple and low-cost HPLC method with UV absorbance detection was developed and validated to simultaneously determine strychnine and brucine, the most abundant alkaloids in the processed Semen Strychni, in rat tissues (kidney, liver, spleen, lung, heart, stomach, small intestine, brain and plasma). … Then the method was used to measure the tissue distribution of strychnine and brucine after intravenous administration of 1 mg/kg crude alkaloids fraction (CAF) extracted from the processed Semen Strychni. …
  • NAID 130000678854

Related Links

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strychnineとは。意味や和訳。[名][U]《薬学》ストリキニーネ:マチンの種子から採る中枢神経興奮剤.strych・nin・igrave;sm[名][U]ストリキニーネ中毒. - goo辞書は国語、英和、和英、中国語、百科事典等からまとめて探せる辞書検索サービス ...


Related Pictures

Skeletal formula of strychnineOprez! Ovo su najotrovnije supstance na svetuPoison Strychnine LabelStrychnine tree - Bild herunterladenMolécule de strychnine helpless to the unfavorable strychnine poisoning impacts of strychnine



★リンクテーブル★
リンク元ストリキニーネ
拡張検索strychnine poisoning

ストリキニーネ」

  [★]

strychnine
strychninum
ストリキニン
硝酸ストリキニーネ strychnini nitras
ホミカエキス


  • 痙攣薬
  • アルカロイド

薬理作用

SPC.210
  • グリシン受容体の拮抗阻害薬
  • 脊髄の抑制物質であるグリシンに拮抗することで、Renshaw細胞のネガティブフィードバックを解除する→興奮↑

中毒症状

SPC.210
  • 運動ニューロンの興奮により後弓反張をきたす
  • 知覚神経刺激に過敏。軽い刺激でけいれんを誘発
  • 意識は清明であるが、痛みに敏感で不安と恐怖を伴う
  • 呼吸麻痺と乳酸アシドーシスで死亡

治療

  • 隔離
  • 気道確保
  • ジアゼパムの投与
  • 全身麻酔
  • 神経筋接合部遮断薬の投与

薬効薬理

ホミカエキス散「ホエイ」として
  • エキスを単純胃瘻管造設イヌの胃内に投与するとき胃液分泌にほとんど変化は認められないが、コンズランゴ冷浸エキスを同時に適用するとき胃液分泌増加し酸度も上昇する。更にエキス又はチンキを単純胃瘻管造設イヌの口内又は胃内に投与するとき胃液分泌、酸度に変化を与えないし、胃、小腸に恒久性瘻管造設イヌになめさせるか胃内投与するとき、バルーン法で胃運動に著しい変化は認められない。

なおstrychnineをヒト、イヌの口内又は胃内に投与すると、ゲンチアナチンキとほぼ同様の効果があるという。また脊髄において抑制性シナプス後電位を減弱させてけいれんを引き起こすが、グリシン受容体に特異的に結合することが知られている。ペントバルビタールなどで麻酔したイヌに静脈内投与すると血圧上昇と心拍数増加が現れる。

参考

  • ホミカエキス散「ホエイ」
[display]http://www.info.pmda.go.jp/go/pack/2333005B1104_2_02/2333005B1104_2_02?view=body

strychnine poisoning」

  [★] ストリキニーネ中毒