- 溶媒露出の
WordNet
- easy to get along with or talk to; friendly; "an accessible and genial man"
- capable of being read with comprehension; "readily accessible to the nonprofessional reader"; "the tales seem more approachable than his more difficult novels" (同)approachable
- capable of being reached; "a town accessible by rail"
- easily obtained; "most students now have computers accessible"; "accessible money"
- find the solution to (a problem or question) or understand the meaning of; "did you solve the problem?"; "Work out your problems with the boss"; "this unpleasant situation isnt going to work itself out"; "did you get it?"; "Did you get my meaning?"; "He (同)work_out, figure out, puzzle out, lick, work
- capable of meeting financial obligations
- a liquid substance capable of dissolving other substances; "the solvent does not change its state in forming a solution" (同)dissolvent, dissolver, dissolving agent, resolvent
PrepTutorEJDIC
- (またget-at-able)近づきやすい,入りやすい,達しうる / 《補語にのみ用いて》(感情などに)動かされやすい,(…の)影響を受けやすい《+『to』+『名』》
- 〈問題など〉‘を'『解く』,解明する,解決する
- (借金の)支払い能力がある / 溶解力のある,溶かす / 溶剤,溶媒 / 解決策
UpToDate Contents
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- 1. 血液製剤の病原体不活化 pathogen inactivation of blood products
- 2. 小児および思春期における吸入剤の乱用 inhalant abuse in children and adolescents
- 3. 血漿成分の臨床使用 clinical use of plasma components
- 4. 輸血関連急性肺障害（TRALI） transfusion related acute lung injury trali
- 5. 遺伝性血管浮腫：急性発作の治療 hereditary angioedema treatment of acute attacks
English Journal
- Influence of cysteine and methionine availability on protein peroxide scavenging activity and phenolic stability in emulsions.
- Zhou L, Elias RJ.Author information Department of Food Science, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA, USA.AbstractPlant phenolics are secondary metabolites that have been shown to confer beneficial health effects in humans. However, many of these compounds undergo metal-catalysed oxidation reactions, leading to the generation of hydrogen peroxide (H2O2) and other reactive oxygen species that may negatively impact product stability. In proteins, methionine (Met) and cysteine (Cys) are capable of reacting directly with peroxides. Thus, the dairy proteins, casein (CAS) and β-lactoglobulin (BLG), were examined for their ability to scavenge H2O2 (400μM) and influence (-)-epigallocatechin-3-gallate (EGCG) oxidation (400μM) in Tween- or sodium dodecyl sulphate (SDS)-stabilised hexadecane emulsions. To examine the effect that the accessibility of these amino acids have on their peroxide scavenging activities, proteins were pre-treated with tert-butyl hydroperoxide (TBHP), a bulky peroxide, to oxidise only solvent accessible Met residues or H2O2, the smallest peroxide, to oxidise buried Met residues. In CAS treatments, higher Met content yielded greater peroxide scavenging activity and EGCG stability. CAS treatments also showed significantly higher peroxide scavenging activity compared to the corresponding BLG treatment. However, BLG peroxide scavenging activity was greatly enhanced in SDS-stabilised emulsions due to protein denaturation and subsequent exposure of previously buried Cys residues.
- Food chemistry.Food Chem.2014 Mar 1;146:521-30. doi: 10.1016/j.foodchem.2013.09.082. Epub 2013 Sep 25.
- Plant phenolics are secondary metabolites that have been shown to confer beneficial health effects in humans. However, many of these compounds undergo metal-catalysed oxidation reactions, leading to the generation of hydrogen peroxide (H2O2) and other reactive oxygen species that may negatively impa
- PMID 24176377
- Crystal structure and biochemical characterization of a manganese superoxide dismutase from Chaetomium thermophilum.
- Haikarainen T1, Frioux C1, Zhnag LQ2, Li DC3, Papageorgiou AC4.Author information 1Turku Centre for Biotechnology, University of Turku, BioCity, Turku 20521, Finland; Åbo Akademi University, BioCity, Turku 20521, Finland.2Department of Environmental Biology, Shandong Agricultural University, Taian, Shandong 271018, China; Department of Chemistry and Chemical Engineering, Taishan Medical College, Taian, Shandong 271016, China.3Department of Environmental Biology, Shandong Agricultural University, Taian, Shandong 271018, China.4Turku Centre for Biotechnology, University of Turku, BioCity, Turku 20521, Finland; Åbo Akademi University, BioCity, Turku 20521, Finland. Electronic address: tassos.papageorgiou@btk.fi.AbstractA manganese superoxide dismutase from the thermophilic fungus Chaetomium thermophilum (CtMnSOD) was expressed in Pichia pastoris and purified to homogeneity. Its optimal temperature was 60°C with approximately 75% of its activity retained after incubation at 70°C for 60min. Recombinant yeast cells carrying C. thermophilum mnsod gene exhibited higher stress resistance to salt and oxidative stress-inducing agents than control yeast cells. In an effort to provide structural insights, CtMnSOD was crystallized and its structure was determined at 2.0Å resolution. The overall architecture of CtMnSOD was found similar to other MnSODs with highest structural similarities obtained against a MnSOD from the thermotolerant fungus Aspergillus fumigatus. In order to explain its thermostability, structural and sequence analysis of CtMnSOD with other MnSODs was carried out. An increased number of charged residues and an increase in the number of intersubunit salt bridges and the Thr:Ser ratio were identified as potential reasons for the thermostability of CtMnSOD.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Feb;1844(2):422-9. doi: 10.1016/j.bbapap.2013.11.014. Epub 2013 Dec 3.
- A manganese superoxide dismutase from the thermophilic fungus Chaetomium thermophilum (CtMnSOD) was expressed in Pichia pastoris and purified to homogeneity. Its optimal temperature was 60°C with approximately 75% of its activity retained after incubation at 70°C for 60min. Recombinant yeast cells
- PMID 24316252
- Late-onset Krabbe disease is predominant in Japan and its mutant precursor protein undergoes more effective processing than the infantile-onset form.
- Hossain MA1, Otomo T1, Saito S2, Ohno K3, Sakuraba H4, Hamada Y1, Ozono K1, Sakai N5.Author information 1Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.2Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido, Japan.3NPO for the Promotion of Research on Intellectual Property Tokyo, Chiyoda-ku, Tokyo, Japan.4Department of Clinical Genetics, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan.5Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Electronic address: norio@ped.med.osaka-u.ac.jp.AbstractKrabbe disease is an autosomal recessive leukodystrophy caused by the deficiency of the galactocerebrosidase (GALC) enzyme. It is pathologically characterized by demyelination of the central and peripheral nervous systems by accumulation of galactosylsphingosine. To date, more than 120 mutations in the GALC gene have been reported worldwide and genotype-phenotype correlations have been reported in some types of mutations. In this study, we analyzed 22 unreported Japanese patients with Krabbe disease and summarized a total of 51 Japanese patients, including 29 previously reported patients. To elucidate how GALC mutations impair enzymatic activity, multiple disease-causing mutations including common mutations and polymorphisms were investigated for enzymatic activity and precursor processing ability with transient expression system. We also performed 3-D enzyme structure analysis to determine the effect of each new mutation. Five novel mutations were detected including one deletion c.1808delT [p.L603X], one nonsense mutation c.1023C>G [p.Y341X], and three missense mutations c.209T>C [p.L70P], c.1054G>A [p.G352R], and c.1937G>C [p.G646A]. For the total of 51 patients, 59% had late-onset forms of Krabbe disease. Seven common mutations accounted for 58% of mutant alleles of patients with Krabbe disease in Japan. Infantile-onset mutations had almost no enzyme activity, while late-onset mutations had 4%-20% of normal enzyme activity. The processing rate of precursor GALC protein to mature form was slower for infantile-onset mutations. Heat stability of the mutant proteins revealed that p.G270D was more stable compared to the other mutations. The constructed 3D-model showed that the residues for Krabbe mutations were less solvent-accessible and located in the core region of GALC protein. In conclusion, we have demonstrated that the most common phenotype in Japan is the late-onset type, that the enzyme activity for GALC mutants is correlated with mutational severity, and that the most pathogenic factor is due to the processing rate from the precursor to the mature protein.
- Gene.Gene.2014 Jan 25;534(2):144-54. doi: 10.1016/j.gene.2013.11.003. Epub 2013 Nov 16.
- Krabbe disease is an autosomal recessive leukodystrophy caused by the deficiency of the galactocerebrosidase (GALC) enzyme. It is pathologically characterized by demyelination of the central and peripheral nervous systems by accumulation of galactosylsphingosine. To date, more than 120 mutations in
- PMID 24252386
Japanese Journal
- Physical origin of hydrophobicity studied in terms of cold denaturation of proteins: comparison between water and simple fluids.
- Yoshidome Takashi,Kinoshita Masahiro
- Physical chemistry chemical physics : PCCP 14(42), 14554-14566, 2012-08-31
- … By considering a solvophobic model protein immersed in water and three species of simple solvents, we analyze the temperature dependence of the changes in free energy, energy, and entropy of the solvent upon protein unfolding. … Each of the changes is decomposed into two terms, which depend on the excluded volume and on the area and curvature of the solvent-accessible surface, respectively. …
- NAID 120005323032
- Morphometric approach to thermodynamic quantities of solvation of complex molecules: Extension to multicomponent solvent.
- Kodama Ryota,Roth Roland,Harano Yuichi,Kinoshita Masahiro
- The Journal of chemical physics 135(4), 2011-07-28
- … Here, we extend it to a solvent consisting of m components. … The MA is applied to each term in a formally separate manner: The term is expressed as a linear combination of the four geometric measures, excluded volume, solvent-accessible surface area, and integrated mean and Gaussian curvatures of the accessible surface, which are calculated for component j. …
- NAID 120003338824
- タンパク質の特性に基づく<i>unbound</i>ドッキングのための剛体予測手法の改良
- 松崎 裕介,大上 雅史,松崎 由理 [他],佐藤 智之,関嶋 政和,秋山 泰
- 情報処理学会研究報告. BIO, バイオ情報学 2010-BIO-20(4), 1-8, 2010-02-25
- 我々が開発するタンパク質間ドッキング予測システム MEGADOCK において,そのドッキングスコアを算出する目的関数は形状の相補性と静電的相互作用を反映しているが,それぞれの項の重みは対象タンパク質によらず一定である.しかしタンパク質の形状やドッキングにおける構造変化に多様性があるため,目的関数におけるその重みをタンパク質の特性に応じて変化させることにより,予測精度の改善が期待できる.本研究では, …
- NAID 110007990826
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Related Pictures
★リンクテーブル★
| リンク元 | 「溶媒露出」「solvent exposure」 |
| 関連記事 | 「solve」「solvent」「accessible」 |
「溶媒露出」
「solvent exposure」
「solve」
- 解決する、解析する、解消する、(式を)解く
- 関
- analyse、analyses、analysis、analyze、cancel、dissolve、resolution、resolve、settle、solution、unravel、untangle
「solvent」
「accessible」