1アミノ酸置換

WordNet

used of flowers having usually only one row or whorl of petals; "single chrysanthemums resemble daisies and may have more than one row of petals"
a base hit on which the batter stops safely at first base (同)bingle
not divided among or brought to bear on more than one object or objective; "judging a contest with a single eye"; "a single devotion to duty"; "undivided affection"; "gained their exclusive attention" (同)undivided, exclusive
existing alone or consisting of one entity or part or aspect or individual; "upon the hill stood a single tower"; "had but a single thought which was to escape"; "a single survivor"; "a single serving"; "a single lens"; "a single thickness"
having uniform application; "a single legal code for all"
hit a single; "the batter singled to left field"
to make melodious sounds; "The nightingale was singing"
deliver by singing; "Sing Christmas carols"
produce tones with the voice; "She was singing while she was cooking"; "My brother sings very well"
street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
the act of putting one thing or person in the place of another: "he sent Smith in for Jones but the substitution came too late to help" (同)exchange, commutation
an event in which one thing is substituted for another; "the replacement of lost blood by a transfusion of donor blood" (同)permutation, transposition, replacement, switch
pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
the radical -NH2 (同)amino_group

PrepTutorEJDIC

《名詞の前にのみ用いて》『たった一つ』(『一人』)『の』,単独の;《否定文で》ただ一つ(一人)(もない) / 《名詞の前にのみ用いて》『一人用の』・『独身の』・《名詞の前にのみ用いて》個々の,別々の / 単一の,単式の;(花が)一重咲きの,単弁の / 《英》(切符が)片道の / 〈C〉一人,1個;独身者 / 〈C〉《話》(ホテルの部屋,船室,列車寝台などの)一人用 / 〈C〉(野球で)シングルヒット,単打 / 《複数形で》(テニスなどの)シングルスの試合,単試合 / 《英》片道切符 / 《複数形で》《話》1ドル(ポンド)札 / …‘を'1人(1個)だけ選び出す《+『out』+『名,』+『名』+『out』》 / (野球で)シングルヒットを打つ
『歌う』;(…に)歌って聞かせる《+『to』(『for』)+『名』》;(楽器に合わせて)歌う《+『to』+『名』》・〈小鳥・虫などが〉『鳴く』,さえずる / 《文》(…を)詩(歌)にする,(詩(歌)を詠んで)賛美する《+『of』+『名』》・〈小川・風・弾丸・湯沸かし・耳などが〉歌うように鳴る・《米語》自白する;密告する・〈歌〉‘を'歌う・《副詞[句]を伴って》歌って…‘を'(…に)する・…‘を'唱える,詠唱する・《文》…‘を'詩(歌)にする,(詩(歌)に詠んで)賛美する・合唱の集い
酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
(…の)『代用』,代理,置き換え《+for+名》

UpToDate Contents

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1. フェニルケトン尿症の概要 overview of phenylketonuria
2. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children
3. 先天性代謝異常：分類 inborn errors of metabolism classification
4. 遺伝性疾患の基本原則 basic principles of genetic disease
5. 尿素サイクル障害：臨床的特徴および診断 urea cycle disorders clinical features and diagnosis

English Journal

Variation in the ovine PRKAG3 gene.

Yang G1, Zhou H2, Wang R3, Hickford J4.
Gene.Gene.2015 Aug 10;567(2):251-4. doi: 10.1016/j.gene.2015.05.021. Epub 2015 May 9.
The 5'AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that controls cellular energy homeostasis in response to environmental or nutritional stress. The PRKAG3 gene (PRKAG3) encodes the γ3 subunit of the AMPK. Variation in this gene has been found to be associated with meat quality tr
PMID 25967386

Associations between responses to interferon therapy and genetic variation in interleukin-28B and the core region of hepatitis C virus genotype 3a.

Yamada K1, Ishigami M1, Kuzuya T1, Honda T1, Hayashi K1, Goto H1.
Journal of medical virology.J Med Virol.2015 Aug;87(8):1361-7. doi: 10.1002/jmv.24084. Epub 2015 Apr 23.
The single-nucleotide polymorphism (SNP) of interleukin-28B (IL-28B) and mutations in the core region of hepatitis C virus (HCV) genotype 1b have been associated with response to interferon (IFN) therapy. However, whether this IL-28B SNP affects responses to INF therapy for HCV genotype 3a is not kn
PMID 25907669

Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein.

Zhang X1, Wallace OL2, Domi A2, Wright KJ2, Driscoll J2, Anzala O3, Sanders EJ4, Kamali A5, Karita E6, Allen S7, Fast P8, Gilmour J9, Price MA10, Parks CL11.
Virology.Virology.2015 Aug;482:218-24. doi: 10.1016/j.virol.2015.03.035. Epub 2015 Apr 14.
Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb) prevalence and potency. MV plaque reduction neutralization test (PRNT) results indicated that all sera were positive for MV nAbs. Further
PMID 25880113

Japanese Journal

プロビタミンAからビタミンAへの転換とβ-carotene15,15'-monooxygenaseの遺伝子多型(<特集>「ビタミンと遺伝子多型」-ビタミンA-)

高瀬幸子,駿河和仁,寺島健彦 [他],清水正則
ビタミン 87(10), 557-563, 2013-10-25
… On the other hand, single nucleotide polymorphisms (SNPs) for BCMO1 which exist in human genome have been analyzed and the existence of 3,483 SNPs in BCMO1 gene has been identified. … The first report showed that T170M, a SNP of BCMO1 gene with amino acid substitution, was related to hypercarotenemia and hypovitaminosis A in the patients with carotenosis. …
NAID 110009674993

Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase

Nakamichi Yusuke,Yoshioka Aya,Kawai Shigeyuki,Murata Kousaku
Scientific reports 3, 2013-09-11
… In this study, we succeeded in conferring the ability to utilize poly(P) on γ-proteobacterial ATP-specific NADKs through a single amino-acid substitution; … the substituted amino-acid residue is therefore important in determining the phosphoryl-donor specificity of γ-proteobacterial NADKs. …
NAID 120005327028

Variation on Starch Properties and the Relationship to Single Nucleotide Polymorphism in SSIIa in Waxy Rice Collected from Central of Vietnam

Tran Danh Suu,Tran Thi Thu Hoai,Nguyen Thi Lan Hoa,Ha Minh Loan,Dinh Bach Yen,Kumamaru Toshihiro,Satoh Hikaru,Sato Hikaru,熊丸敏博,佐藤光
Journal of the Faculty of Agriculture, Kyushu University 58(2), 247-252, 2013-09
… Twenty two waxy rice cultivars originated from Central Vietnam were used for studying the variation on starch properties and the relationship to single nucleotide polymorphism in the SSIIa gene. … Of the six single nucleotide polymorphism (SNPs) in the coding region, two SNPs, C/T (at site 516 bp) in exon 2 and G/T (at site 3903) in exon 8, were silent substitution while other four caused amino acid replacement. …
NAID 120005326649