selective estrogen-receptor modulators

選択的エストロゲン受容体調節薬 SERMs

WordNet

1. tending to select; characterized by careful choice; "an exceptionally quick and selective reader"- John Mason Brown
2. characterized by very careful or fastidious selection; "the school was very selective in its admissions"
3. a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics (同)oestrogen
4. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. 選択の,染択する / 注意して選ばれた / 淘汰(とうた)の / (無線が)選択度の高い
2. エストロゲン(動物の雌を発情させる卵胞ホルモン)(《英》oestrogen)
3. =sense organ / 受信装置

UpToDate Contents

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• 1. 選択的エストロゲン受容体モジュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators
• 2. 骨粗鬆症の予防および治療のための選択的エストロゲン受容体調節剤 selective estrogen receptor modulators for prevention and treatment of osteoporosis
• 3. 乳癌予防のための選択的エストロゲン受容体調節因子およびアロマターゼ阻害剤 selective estrogen receptor modulators and aromatase inhibitors for breast cancer prevention
• 4. 転移性ホルモン受容体陽性乳癌に対する治療アプローチ：内分泌療法 treatment approach to metastatic hormone receptor positive breast cancer endocrine therapy
• 5. 閉経後の女性における骨粗鬆症のマネージメントの概要 overview of the management of osteoporosis in postmenopausal women

English Journal

• IGFBP-3 sensitizes antiestrogen-resistant breast cancer cells through interaction with GRP78.

• Li C, Harada A, Oh Y.SourceDepartment of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, 23298, USA.
• Cancer letters.Cancer Lett.2012 Dec 28;325(2):200-6. doi: 10.1016/j.canlet.2012.07.004. Epub 2012 Jul 16.
• IGFBP-3 is known to possess intrinsic biological activities such as anti-tumor property in addition to its IGF/IGF-R axis-dependent actions in a variety of human cancers including breast cancer. To investigate the molecular mechanisms underlying the intrinsic biological actions of IGFBP-3 on breast
• PMID 22801219

• The evolution of selective estrogen receptor modulators in osteoporosis therapy.

• Hadji P.SourceDepartment of Endocrinology, Reproductive Medicine, and Osteoporosis, Philipps-University of Marburg , Marburg , Germany.
• Climacteric : the journal of the International Menopause Society.Climacteric.2012 Dec;15(6):513-23. doi: 10.3109/13697137.2012.688079. Epub 2012 Aug 1.
• Selective estrogen receptor modulators (SERMs), which exhibit estrogen receptor agonist or antagonist activity based on the target tissue, have evolved through multiple generations for the prevention and/or treatment of postmenopausal osteoporosis. An ideal SERM would protect bone without stimulatin
• PMID 22853318

Japanese Journal

• The increase in prescriptions of bisphosphonates and the incidence proportion of osteonecrosis of the jaw after risk communication activities in Japan: a hospital-based cohort study.

• Sumi Eriko,Yamazaki Toru,Tanaka Shiro,Yamamoto Keiichi,Nakayama Takeo,Bessho Kazuhisa,Yokode Masayuki
• Pharmacoepidemiology and drug safety 23(4), 398-405, 2014-04
• … During this period, BPs were frequently prescribed, whereas there was no increase in the use of alternative agents, such as selective estrogen receptor modulators. …
• NAID 120005359202

• The role of estrogen in adipose tissue metabolism: insights into glucose homeostasis regulation [Review]

• , ,
• Endocrine Journal 61(11), 1055-1067, 2014
• … There is increasing evidence demonstrating that the female sex hormone, estrogen, regulates adipose development and improves systemic glucose homeostasis in both males and females. … The underlying mechanism linking estrogenic regulation in adipose tissue and systemic glucose metabolism has not been fully elucidated, but is thought to include interactions of estrogen receptor signaling events involving lipolytic and/or lipogenic enzyme activity, free fatty acid metabolism, and adipocytokine production. …
• NAID 130004677950

• Effects of Selective Estrogen Receptor Modulators on Plasma Membrane Estrogen Receptors and Catecholamine Synthesis and Secretion in Cultured Bovine Adrenal Medullary Cells

• , , [他], , , , , ,
• Journal of Pharmacological Sciences 124(1), 66-75, 2014
• … We previously reported the occurrence and function of plasma membrane estrogen receptors in cultured bovine adrenal medullary cells. … Here we report the effects of raloxifene and tamoxifen, selective estrogen receptor modulators, on plasma membrane estrogen receptors and catecholamine synthesis and secretion in these cells. …
• NAID 130003382627

Related Links

• Selective Estrogen Receptor Modulators (SERMs)

Selective estrogen receptor modulators, called SERMs for short, block the effects of estrogen in the breast tissue. Learn more about SERMs today.

• Selective estrogen receptor modulators | Drugs.com

Compare selective estrogen receptor modulators. Includes user reviews and ratings for individual medications. Find related monographs and prescribing information. ... Drugs.com provides accurate and independent information on ...

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★リンクテーブル★

リンク元	「選択的エストロゲン受容体調節薬」
関連記事	「modulator」「selective」「estrogen receptor」

「選択的エストロゲン受容体調節薬」

　　[★]

英

selective estrogen-receptor modulator, selective estrogen-receptor modulators SERMs

関

エストロゲン受容体、エストロゲン

[show details]

選択的エストロゲン受容体調節薬 : 約 6,980 件
選択的エストロゲン受容体調節物質 : 66 件
選択的エストロゲン受容体調節因子 : 約 69 件

• エビスタ ラロキシフェン
• ビビアント バゼドキシフェン

「modulator」

　　[★]

• n.

• 修飾因子、修飾物質、(受容体等へのアロステリック結合によりアゴニスト作用を変化させる薬剤)修飾薬、モジュレーター、変調器

関

effect modifier、modifier

「selective」

　　[★]

• adj.

• 選択的な、選択性の、選択の

関

choice、choose、elective、opt、option、optional、select、selection、selectively、selectivity

　 　 　

「estrogen receptor」

　　[★] エストロゲン受容体 ER