カリウム漏洩チャネル
WordNet
- direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
- a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
- a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
- (often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
- a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
- a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
- tell anonymously; "The news were leaked to the paper"
- a euphemism for urination; "he had to take a leak" (同)wetting, making water, passing water
- have an opening that allows light or substances to enter or go out; "The container leaked gasoline"; "the roof leaks badly"
- soft watery rot in fruits and vegetables caused by fungi
- unauthorized (especially deliberate) disclosure of confidential information (同)news leak
- an accidental hole that allows something (fluid or light etc.) to enter or escape; "one of the tires developed a leak"
- be leaked; "The news leaked out despite his secrecy" (同)leak out
- enter or escape as through a hole or crack or fissure; "Water leaked out of the can into the backpack"; "Gas leaked into the basement"
- a light soft silver-white metallic element of the alkali metal group; oxidizes rapidly in air and reacts violently with water; is abundant in nature in combined forms occurring in sea water and in carnallite and kainite and sylvite (同)K, atomic number 19
- a unit of length of thread or yarn
- official routes of communication; "you have to go through channels"
PrepTutorEJDIC
- 〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
- 〈U〉〈C〉(水・空気・ガス・光などが)漏れること / 〈C〉『漏れ口』,漏れ穴 / 〈C〉(秘密などの)漏えい《+『of』+『名』》 / 〈船・屋根・容器などが〉漏る / (…から,…の中へ)〈水・空気・ガス・光など〉漏れる《+『from』(『into』)+『名』》 / 〈秘密などが〉漏えいする《+『out』》 / 〈水・空気・ガス・光など〉‘を'漏らす / (…に)〈秘密など〉‘を'漏らす《+『名』+『to』+『名』》
- ポタシウム,カリウム(金属元素;化学記号はK)
- 草原,牧草地(meadow)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/09/19 05:53:33」(JST)
[Wiki en表示]
Not to be confused with the small family of two-pore channels.
The two-pore-domain potassium channel is a family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins .[citation needed] Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.
Below is a list of the 15 known two-pore-domain human potassium channels:[1]
Gene |
Channel[2] |
Family |
Aliases |
KCNK1 |
K2p1.1 |
TWIK[3][4] |
TWIK-1 |
KCNK2 |
K2p2.1 |
TREK[3][4] |
TREK-1 |
KCNK3 |
K2p3.1 |
TASK[3][4] |
TASK-1 |
KCNK4 |
K2p4.1 |
TREK[3][4] |
TRAAK[5] |
KCNK5 |
K2p5.1 |
TASK[3][4] |
TASK-2[6] |
KCNK6 |
K2p6.1 |
TWIK[3][4] |
TWIK-2 |
KCNK7 |
K2p7.1 |
TWIK[3][4] |
|
KCNK9 |
K2p9.1 |
TASK[3][4] |
TASK-3 |
KCNK10 |
K2p10.1 |
TREK[3][4] |
TREK-2 |
KCNK12 |
K2p12.1 |
THIK |
THIK-2 |
KCNK13 |
K2p13.1 |
THIK |
THIK-1 |
KCNK15 |
K2p15.1 |
TASK[3][4] |
TASK-5 |
KCNK16 |
K2p16.1 |
TALK[3][4] |
TALK-1 |
KCNK17 |
K2p17.1 |
TALK[3][4] |
TALK-2, TASK-4 |
KCNK18 |
K2p18.1 |
|
TRIK, TRESK[3][4][7][8] |
See also
- Ion channel
- Potassium channel
References
- ^ a b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
- ^ Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, et al. (Dec 2003). "International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels". Pharmacological Reviews. 55 (4): 583–6. doi:10.1124/pr.55.4.9. PMID 14657415.
- ^ a b c d e f g h i j k l m Enyedi P, Czirják G (Apr 2010). "Molecular background of leak K+ currents: two-pore domain potassium channels". Physiological Reviews. 90 (2): 559–605. doi:10.1152/physrev.00029.2009. PMID 20393194.
- ^ a b c d e f g h i j k l m Lotshaw DP (2007). "Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels". Cell Biochemistry and Biophysics. 47 (2): 209–56. doi:10.1007/s12013-007-0007-8. PMID 17652773.
- ^ Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (Jun 1998). "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids". The EMBO Journal. 17 (12): 3297–308. doi:10.1093/emboj/17.12.3297. PMC 1170668. PMID 9628867.
- ^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (Mar 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nature Reviews. Neuroscience. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
- ^ Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K (Jul 2003). "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord". The Journal of Biological Chemistry. 278 (30): 27406–12. doi:10.1074/jbc.M206810200. PMID 12754259.
- ^ Czirják G, Tóth ZE, Enyedi P (Apr 2004). "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin". The Journal of Biological Chemistry. 279 (18): 18550–8. doi:10.1074/jbc.M312229200. PMID 14981085.
External links
- Tandem Pore Domain Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Two-P Potassium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Membrane transport protein: ion channels (TC 1A)
|
|
Ca2+: Calcium channel
|
|
Ligand-gated |
- Inositol trisphosphate receptor
- Ryanodine receptor
|
|
Voltage-gated |
- L-type/Cavα
- N-type/Cavα2.2
- P-type/Cavα
- Q-type/Cavα2.1
- R-type/Cavα2.3
- T-type/Cavα
- α2δ-subunits
- β-subunits
- γ-subunits
- Cation channels of sperm
- Two-pore channel
|
|
|
|
Na+: Sodium channel
|
|
Constitutively active |
- Epithelial sodium channel
|
|
Proton-gated |
- Amiloride-sensitive cation channel
|
|
Voltage-gated |
- Navα
- 1.1
- 1.2
- 1.3
- 1.4
- 1.5
- 1.6
- 1.7
- 1.8
- 1.9
- 7A
- Navβ
|
|
|
|
K+: Potassium channel
|
|
Calcium-activated |
- BK channel
- SK channel
- IK channel
- KCa
- 1.1
- 2.1
- 2.2
- 2.3
- 3.1
- 4.1
- 4.2
- 5.1
|
|
Inward-rectifier |
|
|
Tandem pore domain |
- K2P
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 9
- 10
- 12
- 13
- 15
- 16
- 17
- 18
|
|
Voltage-gated |
- Kvα1-6
- 1.1
- 1.2
- 1.3
- 1.4
- 1.5
- 1.6
- 1.7
- 1.8
-
-
-
-
-
- Kvβ
- KCNIP
- minK/ISK
- minK/ISK-like
- MiRP
- Shaker gene
|
|
|
|
Miscellaneous
|
|
Cl−: Chloride channel |
- Calcium-activated chloride channels
- Anoctamin
- Bestrophin
- Chloride Channel Accessory
- CFTR
- CLCN
- CLIC
- CLNS
|
|
H+: Proton channel |
|
|
M+: CNG cation channel |
|
|
M+: TRP cation channel |
- TRPA (1)
- TRPC
- TRPM
- TRPML
- TRPN
- TRPP
- TRPV
|
|
H2O (+ solutes): Porin |
- Aquaporin
- Voltage-dependent anion channel
- General bacterial porin family
|
|
Cytoplasm: Gap junction |
- Connexin: A
- GJA1
- GJA3
- GJA4
- GJA5
- GJA8
- GJA9
- GJA10
- B
- GJB1
- GJB2
- GJB3
- GJB4
- GJB5
- GJB6
- GJB7
- C
- D
|
|
|
|
By gating mechanism
|
|
Ion channel class |
- Ligand-gated
- Light-gated
- Voltage-gated
- Stretch-activated
|
|
|
|
see also disorders
|
UpToDate Contents
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English Journal
- A role for two-pore Potassium (K2P) channels in endometrial epithelial function.
- Patel SK, Jackson L, Warren AY, Arya P, Shaw RW, Khan RN.SourceAcademic Division of Obstetrics & Gynaecology, University of Nottingham, Derby, UK.
- Journal of cellular and molecular medicine.J Cell Mol Med.2013 Jan 11. doi: 10.1111/j.1582-4934.2012.01656.x. [Epub ahead of print]
- The human endometrial epithelium is pivotal to menstrual cycle progression, implantation and early pregnancy. Endometrial function is directly regulated by local factors that include pH, oxygen tension and ion concentrations to generate an environment conducive to fertilization. A superfamily of pot
- PMID 23305490
- N-glycosylation-dependent control of functional expression of background potassium channels K2P2P2P3.1 and K2P2P2P9.1.
- Mant A, Williams S, Roncoroni L, Lowry E, Johnson D, O'Kelly I.SourceUniversity of Southampton, United Kingdom;
- The Journal of biological chemistry.J Biol Chem.2012 Dec 18. [Epub ahead of print]
- Two-pore domain potassium (K(2P)) channels play fundamental roles in cellular processes by enabling a constitutive leak of potassium from cells in which they are expressed, thus influencing cellular membrane potential and activity. Hence, regulation of these channels is of critical importance to cel
- PMID 23250752
Japanese Journal
- MCFCの電解質揮発現象の可視化 : 電解質量の影響
- <Original Article>The Negatively Activating Potassium Conductance of Rat Cochlear Hair Cells
Related Links
- Tandem pore domain potassium channel - are constitutively open or possess high basal activation, such as the "resting potassium channels" or "leak channels " that set the negative membrane potential of neurons. When open, they allow ...
- The cell membrane contains protein channels, called leak channels that allow Na + or K+ to leak down their concentration gradients. Will Na+ tend to leak INTO or OUT OF the cell? What about K+?
Related Pictures
★リンクテーブル★
[★]
- 英
- potassium leak channel
- 関
- カリウムチャネル
参考
- 1. Potassium leak channels and the KCNK family of two-P-domain subunits.
- PMID 11256078
- 2. News Brief: Structures Solved for K2P Potassium “Leak” Channels. A first look at two-pore-domain channels
- http://www.painresearchforum.org/news/13498-news-brief-structures-solved-k2p-potassium-%E2%80%9Cleak%E2%80%9D-channels
[★]
- 川床、川底。水路、河道
- 海峡
- 水管、導管
- 溝
- 経路、ルート。道筋、方向
- 関
- ion channel、ionic channel
[★]
- 関
- diapedesis、discharge、escape、leakage
[★]
- 関
- leaky