WordNet

complicated in structure; consisting of interconnected parts; "a complex set of variations based on a simple folk melody"; "a complex mass of diverse laws and customs"
a compound described in terms of the central atom to which other atoms are bound or coordinated (同)coordination_compound
a conceptual whole made up of complicated and related parts; "the complex of shopping malls, houses, and roads created a new town" (同)composite
(psychoanalysis) a combination of emotions and impulses that have been rejected from awareness but still influence a persons behavior
the 9th letter of the Roman alphabet (同)i
tiny bits of protoplasm found in vertebrate blood; essential for blood clotting (同)blood_platelet, thrombocyte
a conjugated protein having a carbohydrate component

PrepTutorEJDIC

『いくつかの部分から成る』,複合の,合成の / 『複雑な』,入りくんだ,こみいった(complicated) / 複合体,合成物 / コンプレックス,複合(抑圧されて心に残った複雑なしこり)
『私は』私が
iodineの化学記号
general practitioner一般開業医

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/27 23:16:49」(JST)

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Glycoprotein Ib (GPIb), also known as CD42,^[1] is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury.

It is deficient in the Bernard-Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand's disease.^[2]

Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.^[3]

Components include GP1BA and GP1BB.

It complexes with Glycoprotein IX.

References

^ Bode AP, Read MS, Reddick RL (February 1999). "Activation and adherence of lyophilized human platelets on canine vessel strips in the Baumgartner perfusion chamber". J. Lab. Clin. Med. 133 (2): 200–11. doi:10.1016/S0022-2143(99)90013-6. PMID 9989772.
^ McPherson & Pincus: Henry's Clinical Diagnosis and Management by Laboratory Methods, 21st ed., pp. 760-2 (W.B. Saunders, 2006).
^ McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura". Semin. Hematol. 44 (4 Suppl 5): S3–S11. doi:10.1053/j.seminhematol.2007.11.002. PMID 18096470.

External links

Glycoprotein Ib at the US National Library of Medicine Medical Subject Headings (MeSH)

This protein-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 血小板生物学 platelet biology
2. 血小板機能検査 platelet function testing
3. 止血の概要 overview of hemostasis
4. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function
5. 冠動脈疾患における血小板の役割 the role of platelets in coronary heart disease

English Journal

Platelet GPIb-IX Has Suppressive Effects on Septic Inflammation.

Semple JW.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 May;34(5):962-3. doi: 10.1161/ATVBAHA.114.303367.
PMID 24740189

Platelet Glycoprotein Ib-IX as a Regulator of Systemic Inflammation.

Corken A1, Russell S, Dent J, Post SR, Ware J.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 May;34(5):996-1001. doi: 10.1161/ATVBAHA.113.303113. Epub 2014 Feb 6.
OBJECTIVE: The platelet glycoprotein Ib-IX (GP Ib-IX) receptor is a well-characterized adhesion receptor supporting hemostasis and thrombosis via interactions with von Willebrand factor. We examine the GP Ib-IX/von Willebrand factor axis in murine polymicrobial sepsis, as modeled by cecal ligation a
PMID 24504734

Primary haemostasis: newer insights.

Berndt MC1, Metharom P, Andrews RK.
Haemophilia : the official journal of the World Federation of Hemophilia.Haemophilia.2014 May;20 Suppl 4:15-22. doi: 10.1111/hae.12427.
At the same time as biophysical and omics approaches are drilling deeper into the molecular details of platelets and other blood cells, as well as their receptors and mechanisms of regulation, there is also an increasing awareness of the functional overlap between human vascular systems. Together, t
PMID 24762270