癌遺伝子産物v-Akt
WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- the 22nd letter of the Roman alphabet (同)v
- a gene that disposes normal cells to change into cancerous tumor cells (同)transforming_gene
PrepTutorEJDIC
- 蛋白(たんばく)質
- answer / ampere
- vanadium の化学記号
UpToDate Contents
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English Journal
- LY294002 and Metformin Cooperatively Enhance the Inhibition of Growth and the Induction of Apoptosis of Ovarian Cancer Cells.
- Li C, Liu VW, Chan DW, Yao KM, Ngan HY.SourceDepartments of *Obstetrics and Gynecology, and †Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
- International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.Int J Gynecol Cancer.2011 Nov 11. [Epub ahead of print]
- BACKGROUND: The phosphoinositide 3 kinase (PI3K)/v-akt murine thymoma viral oncogene homolog (AKT)/mammalian target of rapamycin (mTOR) pathway is frequently aberrantly activated in ovarian cancer and confers the chemoresistant phenotype of ovarian cancer cells. LY294002 (PI3K inhibitor) and metform
- PMID 22080879
- Bcr-Abl oncogene stimulates Jab1 expression via cooperative interaction of β-catenin and STAT1 in chronic myeloid leukemia cells.
- Yang KT, Wang MC, Chen JY, Hsu MC, Hung WC.SourceInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
- Journal of cellular physiology.J Cell Physiol.2011 Nov;226(11):2849-56. doi: 10.1002/jcp.22633.
- Jab1, a co-activator of AP-1 transcription factor and the fifth subunit of the COP9 signalosome, mediates degradation of the tumor suppressor p53 and p27(Kip1) and functions as a tumor promoter in different types of human cancer. In this study, we show that inhibition of Bcr-Abl oncogene by imatinib
- PMID 21935931
Japanese Journal
- Development of an Immunohistochemical Protein Quantification System in Conjunction with Tissue Microarray Technology for Identifying Predictive Biomarkers for Phosphatidylinositol 3-Kinase Inhibitors
- Isoyama Sho,Yoshimi Hisashi,Dan Shingo,Okamura Mutsumi,Seki Mariko,Irimura Tatsuro,Yamori Takao
- Biological and Pharmaceutical Bulletin 35(9), 1607-1613, 2012
- … We previously reported that expression of phosphorylated Akt determined by immunoblot analysis correlated with the antitumor efficacy of a PI3K inhibitor ZSTK474 in vitro and in vivo, suggesting that it might be used as a predictive biomarker. … In this study, to evaluate biomarker candidates in in vivo tumor samples, we developed an immunohistochemical protein detection/quantification system in conjunction with the tissue microarray technology using a panel of 24 human tumor xenografts (JFCR24). …
- NAID 130001872078
Related Links
- Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D. NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological ...
- Oncogene Protein v-akt information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Oncogene Protein v-akt Description of Oncogene Protein v-akt Oncogene ...
Related Pictures
★リンクテーブル★
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- 英
- oncogene protein v-Akt
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- 同
- Akt protein、Aktタンパク質
- Aktはアポトーシスを妨げ細胞周期をすすめるタンパク質をリン酸化。
- mTORと(mTORの標的である)p70S6kは細胞の増殖を促すタンパクの合成を亢進する。
[★]
- 関
- oncogene product、oncoprotein
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[★]
[★]
対
- 関
- pair、paired、pairwise、versus