関: NF45

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
(weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
『核の』,細胞核の / [『原子』]『核の』
蛋白(たんばく)質

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English Journal

The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators.

Nakadai T1, Fukuda A2, Shimada M1, Nishimura K2, Hisatake K3.
The Journal of biological chemistry.J Biol Chem.2015 Oct 30;290(44):26832-45. doi: 10.1074/jbc.M115.688317. Epub 2015 Sep 17.
The c-fos gene is rapidly induced to high levels by various extracellular stimuli. We used a defined in vitro transcription system that utilizes the c-fos promoter to purify a coactivator activity in an unbiased manner. We report here that NF45-NF90 and NF45-NF110, which possess archetypical double-
PMID 26381409

The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.

Wandrey F1, Montellese C2, Koos K3, Badertscher L2, Bammert L2, Cook AG4, Zemp I1, Horvath P3, Kutay U5.
Molecular and cellular biology.Mol Cell Biol.2015 Oct;35(20):3491-503. doi: 10.1128/MCB.00306-15. Epub 2015 Aug 3.
The interleukin enhancer binding factors ILF2 (NF45) and ILF3 (NF90/NF110) have been implicated in various cellular pathways, such as transcription, microRNA (miRNA) processing, DNA repair, and translation, in mammalian cells. Using tandem affinity purification, we identified human NF45 and NF90 as
PMID 26240280

Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers.

Todaka H1, Higuchi T1, Yagyu K1, Sugiyama Y1, Yamaguchi F1, Morisawa K1, Ono M2, Fukushima A3, Tsuda M4, Taniguchi T1, Sakamoto S5.
Molecular and cellular biology.Mol Cell Biol.2015 Jul;35(13):2295-308. doi: 10.1128/MCB.01297-14. Epub 2015 Apr 27.
MicroRNAs (miRNAs) are involved in the progression and suppression of various diseases through translational inhibition of target mRNAs. Therefore, the alteration of miRNA biogenesis induces several diseases. The nuclear factor 90 (NF90)-NF45 complex is known as a negative regulator in miRNA biogene
PMID 25918244

Japanese Journal

肝臓の脂質蓄積における新たな制御メカニズム：肝PPARγ-fsp27シグナルの役割

松末公彦
YAKUGAKU ZASSHI 132(7), 823-829, 2012
… Fat-specific protein 27 (fsp27) was originally isolated by screening for genes specifically expressed in fully differentiated mouse adipocytes. … Fsp27 and cell death-inducing DFF45-like effector (CIDE) C, the human homologue of fsp27, belong to the CIDE family. … Fsp27, which is highly expressed in mouse white and brown adipose tissues, was recently reported to be a lipid droplet (LD)-binding protein that promotes lipid accumulation in adipocytes. …
NAID 130001888696

Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide.

Miyata Yoshihiko,Yoneda Yoshihiro,Yahara Ichiro
Molecular and cellular biochemistry 356(1-2), 191-200, 2011-10-00
… The nuclear localization signal sequence (NLS) of SV40 Large T antigen is essential and sufficient for the nuclear translocation of the protein. … In this study, we investigated effects of the NLS-peptide of Large T antigen on protein phosphorylation. …
NAID 80022043429

サイトカインと破骨細胞分化におけるシグナル伝達

増原正明,マスハラマサアキ,MASUHARA Masaaki
鹿児島大学歯学部紀要 30, 45
… Two cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kB ligand (RANKL) are indispensable in the osteoclast differentiation process. … RANKL expressed by osteoblasts activates TRAF adaptor proteins, c-Fos, and eventually induction of nuclear factor of activated T cells (NFAT) c1, the master transcription factor of osteoclastogenesis. …
NAID 120005231978