- 関
- nuclear import、nuclear transport、nucleocytoplasmic transport
WordNet
- transfer (electronic data) out of a database or document in a format that can be used by other programs
- commodities (goods or services) sold to a foreign country (同)exportation
- cause to spread in another part of the world; "The Russians exported Marxism to Africa"
- sell or transfer abroad; "we export less than we import and have a negative trade balance"
- of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
- (weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
- constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
- of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
- the commercial activity of selling and shipping goods to a foreign country (同)exportation
PrepTutorEJDIC
- (外国へ)〈商品〉‘を'『輸出する』《+『名』+『to』+『名』》 / 〈C〉『輸出品』 / 〈U〉(…の)『輸出』《+『of』+『名』》
- 『核の』,細胞核の / [『原子』]『核の』
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/15 03:24:27」(JST)
[Wiki en表示]
A nuclear export signal (NES) is a short amino acid sequence of 4 hydrophobic residues in a protein that targets it for export from the cell nucleus to the cytoplasm through the nuclear pore complex using nuclear transport. It has the opposite effect of a nuclear localization signal, which targets a protein located in the cytoplasm for import to the nucleus. The NES is recognized and bound by exportins. In silico analysis of known NESs found the most common spacing of the hydrophobic residues to be LxxxLxxLxL, where "L" is a hydrophobic residue (often leucine) and "x" is any other amino acid; the spacing of these hydrophobic residues may be explained by examination of known structures that contain an NES, as the critical residues usually lie in the same face of adjacent secondary structures within a protein, which allows them to interact with the exportin.[1] Ribonucleic acid (RNA) are composed of nucleotides, and thus, lack the nuclear export signal to move out of the nucleus. As a result, most forms of RNA will bind to a protein molecule to form a ribonucleoprotein complex to be exported from the nucleus.
Nuclear export first begins with the binding of Ran-GTP (a G-protein) to exportin. This causes a shape change in exportin, increasing its affinity for the export cargo. Once the cargo is bound, the Ran-exportin-cargo complex moves out of the nucleus through the nuclear pore. GTPase activating proteins (GAPs) then hydrolyze the Ran-GTP to Ran-GDP, and this causes a shape change and subsequent exportin release. Once no longer bound to Ran, the exportin molecule loses affinity for the nuclear cargo as well, and the complex falls apart. Exportin and Ran-GDP are recycled to the nucleus separately, and guanine exchange factor (GEF) in the nucleus switches the GDP for GTP on Ran.
NESbase[edit]
NESbase is a database of proteins, experimentally authenticated Leucine-rich Nuclear Export Signals (NES). A research was conducted by Center for Biological Sequence Analysis, Technical University of Denmark; and Department of Protein Chemistry, University of Copenhagen to validate NESbase version 1.0. Every entry in its database includes information whether Nuclear Export Signals was sufficient for export or it was only mediated transport by CRM1, the export receptor.[2]
References[edit]
- ^ la Cour T, Kiemer L, Mølgaard A, Gupta R, Skriver K, Brunak S (June 2004). "Analysis and prediction of leucine-rich nuclear export signals". Protein Eng. Des. Sel. 17 (6): 527–36. doi:10.1093/protein/gzh062. PMID 15314210.
- ^ Tanja la Cour, Ramneek Gupta1, Kristoffer Rapacki, Karen Skriver, Flemming M. Poulsen, Søren Brunak (2003). "NESbase version 1.0: a database of nuclear export signals". Nucleic acids research 31 (1): 393–396. doi:10.1093/nar/gkg101. PMID 12520031.
External links[edit]
Eukaryotic Linear Motif resource motif class TRG_NES_CRM1_1
UpToDate Contents
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English Journal
- Insulin-Mediated Downregulation of Apolipoprotein A-I Gene in Human Hepatoma Cell Line HepG2: The Role of Interaction Between FOXO1 and LXRβ Transcription Factors.
- Shavva VS1,2, Bogomolova AM3, Nikitin AA1,3, Dizhe EB1, Tanyanskiy DA1,4, Efremov AM1,2, Oleinikova GN1, Perevozchikov AP1,2, Orlov SV1,2.
- Journal of cellular biochemistry.J Cell Biochem.2017 Feb;118(2):382-396. doi: 10.1002/jcb.25651. Epub 2016 Sep 30.
- Apolipoprotein A-I (ApoA-I) is a key component of high density lipoproteins which possess anti-atherosclerotic and anti-inflammatory properties. Insulin is a crucial mediator of the glucose and lipid metabolism that has been implicated in atherosclerotic and inflammatory processes. Important mediato
- PMID 27404023
- Nuclear transportation of exogenous epidermal growth factor receptor and androgen receptor via extracellular vesicles.
- Read J1, Ingram A1, Al Saleh HA1, Platko K1, Gabriel K2, Kapoor A3, Pinthus J3, Majeed F1, Qureshi T4, Al-Nedawi K5.
- European journal of cancer (Oxford, England : 1990).Eur J Cancer.2017 Jan;70:62-74. doi: 10.1016/j.ejca.2016.10.017. Epub 2016 Nov 22.
- Epidermal growth factor receptor (EGFR) plays a central role in the progression of several human malignancies. Although EGFR is a membrane receptor, it undergoes nuclear translocation, where it has a distinct signalling pathway. Herein, we report a novel mechanism by which cancer cells can directly
- PMID 27886573
- Targeting Intrinsic and Extrinsic Vulnerabilities for the Treatment of Multiple Myeloma.
- Anreddy N1, Hazlehurst LA1.
- Journal of cellular biochemistry.J Cell Biochem.2017 Jan;118(1):15-25. doi: 10.1002/jcb.25617. Epub 2016 Jun 21.
- Multiple myeloma (MM) is a malignant plasma cell disorder, clinically characterized by osteolytic lesions, immunodeficiency, and renal disease. Over the past decade, MM therapy is significantly improved by the introduction of novel therapeutics such as immunomodulatory agents (thalidomide, lenalidom
- PMID 27261328
Japanese Journal
- 広島・長崎への原爆投下から福島第一原発崩壊へ─日米核同盟,核燃料サイクル,原発の新増設・脱原発を中心に─
- 日本産農林水産物輸出の現状と課題-香港・台湾向け輸出を対象に-
- Nuclear localization domains of GATA activator Gln3 are required for transcription of target genes through dephosphorylation in Saccharomyces cerevisiae
- Journal of bioscience and bioengineering 120(2), 121-127, 2015-08
- NAID 40020567220
Related Links
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Related Pictures
![Nuclear+Export.png](https://1mg.info/0/b/j/1453.jpg)
![mrna nuclear pore](https://1mg.info/0/b/j/1454.jpg)
![Nuclear export works like](https://1mg.info/0/b/j/1455.jpg)
![…nuclear export of mRNA in yeast](https://1mg.info/0/b/j/1456.jpg)
![Nuclear Export of Viral RNAs : Joachim](https://1mg.info/0/b/j/1457.jpg)
★リンクテーブル★
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- 関
- nuclear export、nuclear import、nuclear localization、nuclear translocation、nucleocytoplasmic transport
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- 英
- nuclear export
- 関
- 核移行、核内移行、核外輸送、核細胞質間輸送
[★]
- 関
- nuclear export、nuclear transport、nucleocytoplasmic transport
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- 関
- nuclear export、nuclear import、nuclear transport
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- 英
- nuclear export
- 関
- 核外移行
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- 関
- NES
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- 関
- drain、draining、efferent、egest、egestion、eject、eliminate、elimination、emission、emit、excrete、excretion、expel
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- 関
- cell nuclei、cell nucleus、nuclei、nucleo、nucleus