WordNet

stated explicitly or in detail; "needed a specific amount"
a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria"
(sometimes followed by `to'
being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements"
relating to or distinguishing or constituting a taxonomic species; "specific characters"

PrepTutorEJDIC

《名詞の前にのみ用いて》『特定の』,一定の・『明確な』,明白な・(そのものに)『特有の』,独特の《+『to』+『名』》・〈C〉(…の)特効薬《+『for』+『名』》・《複数形で》明細,細部(details)
神経単位,神経細胞,ニューロン,ノイロン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/05 18:33:07」(JST)

wiki en

Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.^[3]^[4] Gamma-enolase is a phosphopyruvate hydratase.

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.^[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]

File:WP534.png

Glycolysis and Gluconeogenesis edit

^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

Utility

Neuron-specific enolase (NSE) immunostaining of a cerebellar hemangioblastoma.

Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small cell carcinomas which are neuroendocrine in origin. NSE is therefore a useful tumor marker for lung cancer patients.^[5]

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ ^a ^b "ENO2 enolase 2 (gamma, neuronal)". NCBI Entrez Gene database.
^ Online Mendelian Inheritance in Man (OMIM) Enolase 2 -131360
^ Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS (April 2003). "Molecular characterization of prostatic small-cell neuroendocrine carcinoma". Prostate. 55 (1): 55–64. PMID 12640661. doi:10.1002/pros.10217.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 脳卒中のための血液バイオマーカー blood biomarkers for stroke
2. 低酸素性虚血性脳障害：評価および予後 hypoxic ischemic brain injury evaluation and prognosis
3. 小細胞肺癌の病理および病期分類 pathobiology and staging of small cell carcinoma of the lung
4. 神経芽腫の疫学、病因、および病理 epidemiology pathogenesis and pathology of neuroblastoma
5. クロイツフェルト・ヤコブ病 creutzfeldt jakob disease

English Journal

Autologous Platelet-Rich Plasma Promotes Neurogenic Differentiation of Human Adipose-Derived Stem Cells in vitro.

Li H, Han Z, Liu D, Zhao P, Liang S, Xu K.Source1Department of Plastic and Aesthetic Surgery, Zhongshan Hospital of Sun Yat-Sen University , Zhongshan , P. R. China.
The International journal of neuroscience.Int J Neurosci.2013 Mar;123(3):184-90. doi: 10.3109/00207454.2012.742077. Epub 2013 Jan 10.
ABSTRACT Nervous system injury causes severe medical and social problems worldwide, and doctors have not found any ultimate solutions to it until now. The regenerative medicine using stem cells is a promising technology to conquer this challenge. In this study, we explored the influence of platele
PMID 23126279

Primary supratentorial atypical teratoid/rhabdoid tumor in children: a report of two cases.

Li F, Gui Q, Piao Y.Source1Department of Pathology, General PLA Hospital, Beijing, China.
Journal of child neurology.J Child Neurol.2013 Mar;28(3):399-403. doi: 10.1177/0883073812444314. Epub 2012 May 1.
Atypical teratoid/rhabdoid tumor is a highly malignant tumor of the central nervous system, usually occurring in the posterior fossa in infants and young children. Supratentorial example is relatively rare, especially with involvement of the cerebral ventricle system. Herein, we reported 2 cases of
PMID 22550091

Multiple carcinosarcomas of the esophagus and stomach.

Xu F, Zou WB, Li XP, Xu YM, Qi XF, Hu LH, Li ZS, Yao DK.SourceDepartment of Gastroenterology, Yinzhou People's Hospital, Ningbo, Zhejiang 315040;
Oncology letters.Oncol Lett.2013 Mar;5(3):1017-1021. Epub 2012 Dec 28.
Carcinosarcoma is an uncommon biphasic malignant neoplasm consisting of both carcinomatous and sarcomatous components. We report a case of an 84-year-old male with multiple carcinosarcomas occurring in the esophagus and stomach. Endoscopically, a bulky pedunculated polypoid lesion was observed in th
PMID 23426899

Japanese Journal

I型胃カルチノイド腫瘍が併存した肝転移を伴う直腸内分泌細胞癌の1例

工藤雅史,志田晴彦,東久登,根岸真人,山形誠一,増田幸蔵,井上雅文
日本臨床外科学会雑誌 76(2), 344-349, 2015
症例は50歳，女性．2013年4月，血便および健診超音波検査での肝腫瘍精査目的で受診した．下部消化管内視鏡検査で直腸Raに隆起性病変を認め，生検で低分化腺癌および内分泌細胞癌の併存と診断された．上部消化管内視鏡検査ではA型胃炎に伴う多発胃カルチノイド腫瘍が観察された．腫瘍マーカーはNSEが45.8ng/mlと高値を示した．CT検査では肝S4に5cm大の腫瘤を認め，直腸傍リンパ節も腫大していた．以上 …
NAID 130005095222

小細胞癌への転化をきたしたEGFR遺伝子変異陽性肺腺癌の1例

樋浦徹,才田優,小山建一,阿部徹哉,田中洋史,横山晶
肺癌 55(3), 155-160, 2015
背景．EGFR-TKIの耐性機序のひとつとして，SCLCへの転化があり，SCLCに準じた化学療法が奏効するとの報告がなされている．症例．症例は47歳，女性．2010年に肺腺癌（pT2aN2M0, stage IIIA）にて，左上葉切除術を施行．その後再発し，2012年よりゲフィチニブでの治療を開始．腫瘍は縮小しPRを維持していたが，2013年に急速な胸水増加と胸膜病変の増大，NSEの上昇がみられ， …
NAID 130005089227

Portion of E-DCIS Lesion Coexisting With Intraductal Papilloma of the Breast:—Immunochemistry of Synaptophysin for Diagnosis by Core Needle Biopsy—

Maeda Ichiro,Kanemaki Yoshihide,Uejima Tomoko [他],Tajima Shinya,Nagasawa Satoi,Ohi Ryoko,Tsugawa Koichiro,Takagi Masayuki
Journal of St. Marianna University 6(1), 77-83, 2015
… Immunopositivity for neuroendocrine markers [NEs: synaptophysin (syn), chromogranin A (CGA), CD56, CD57, and neuron-specific enolase] is evidence of the presence of tumor cells with neuroendocrine cell differentiation in the breast. …
NAID 130005085598

Related Pictures

Neuron Specific Enolase (NSE) | Diagnostic BioSystems - Immunohistochemistry, Primary NEURON-SPECIFIC ENOLASE (NSE) Immnunohistochemistry Control Histology Slides Human Neuron specific Enolase ELISA Kit (ab217778) | アブカム

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拡張検索	「neuron-specific enolase」
関連記事	「specific」「neuro」「enolase」

「neuron-specific enolase」

ENO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TE6, 2AKM, 2AKZ, 3UCC, 3UCD, 3UJE, 3UJF, 3UJR, 3UJS, 4ZCW, 4ZA0
Identifiers
Aliases	ENO2, HEL-S-279, NSE, Enolase 2
External IDs	MGI: 95394 HomoloGene: 74414 GeneCards: ENO2
Gene ontology
Molecular function	• metal ion binding; • protein binding; • lyase activity; • magnesium ion binding; • phosphopyruvate hydratase activity;
Cellular component	• cytoplasm; • cytosol; • plasma membrane; • phosphopyruvate hydratase complex; • extracellular exosome; • extracellular space; • membrane;
Biological process	• gluconeogenesis; • canonical glycolysis; • glycolytic process;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	2026
	13807
	ENSG00000111674
	ENSMUSG00000004267
	P09104; Q6FHV6
	P17183
	NM_001975
	NM_013509; NM_001302642
	NP_001966; NP_001966.1
	NP_001289571; NP_038537
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★] 神経特異性エノラーゼ

「specific」

　　[★]

adj.

(～に関して)明確な、はっきりとした(exact precise)、具体的な(in, about)
(比較)(限定)特定の(particular)、一定の(⇔general)
(～に)特有の、独特の(to)
(比較)(医学)(～に)渡航のある(for)。特殊な
(生物)(生物)種の
医学)特異の
(物理)比の。物質固有の。単位質量・長さ・面積・容積で

n.

関: specifically、specificity

「neuro」

　　[★]

comb form.

ニューロ、神経

関: nerve、nervi、nervous、nervus、neural、neuron

「enolase」

　　[★]

エノラーゼ

関: neuron-specific enolase、phosphopyruvate hydratase

[WikiPathways-5] The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

[1] "Human PubMed Reference:".

[2] "Mouse PubMed Reference:".

[entrez-3] "ENO2 enolase 2 (gamma, neuronal)". NCBI Entrez Gene database.

[4] Online Mendelian Inheritance in Man (OMIM) Enolase 2 -131360

[pmid12640661-6] Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS (April 2003). "Molecular characterization of prostatic small-cell neuroendocrine carcinoma". Prostate. 55 (1): 55–64. PMID 12640661. doi:10.1002/pros.10217.

v t e Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase
4.2.2: Acting on polysaccharides	Hyaluronate lyase
4.2.3: Acting on phosphates	Threonine synthase
4.2.99: Other	Carboxymethyloxysuccinate lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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案内

neuron specific enolase