出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/16 09:31:17」(JST)
| It has been suggested that this article be merged with Enolase. (Discuss) Proposed since July 2013. |
| phosphopyruvate hydratase | |||||||||
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| Identifiers | |||||||||
| EC number | 4.2.1.11 | ||||||||
| CAS number | 9014-08-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a phosphopyruvate hydratase (EC 4.2.1.11) is an enzyme that catalyzes the chemical reaction
Hence, this enzyme has one substrate, 2-phospho-D-glycerate, and two products, phosphoenolpyruvate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming). Other names in common use include enolase, 2-phosphoglycerate dehydratase, 14-3-2-protein, nervous-system specific enolase, phosphoenolpyruvate hydratase, 2-phosphoglycerate dehydratase, 2-phosphoglyceric dehydratase, 2-phosphoglycerate enolase, gamma-enolase, and 2-phospho-D-glycerate hydro-lyase. This enzyme participates in glycolysis/gluconeogenesis. At least one compound, Phosphonoacetohydroxamate is known to inhibit this enzyme. The human gene that makes this enzyme is ENO2.
As of late 2007, 27 structures have been solved for this class of enzymes, with PDB accession codes 1E9I, 1EBG, 1EBH, 1ELS, 1IYX, 1L8P, 1NEL, 1OEP, 1ONE, 1P43, 1P48, 1PDY, 1PDZ, 1TE6, 1W6T, 2AKM, 2AKZ, 2AL1, 2AL2, 2FYM, 2ONE, 2PA6, 3ENL, 4ENL, 5ENL, 6ENL, and 7ENL.
This EC 4.2 enzyme-related article is a stub. You can help Wikipedia by expanding it.
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| リンク元 | 「ホスホピルビン酸ヒドラターゼ」「enolase」 |
| 関連記事 | 「hydratase」 |