WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
constituting a tube; having hollow tubes (as for the passage of fluids) (同)cannular, tubelike, tube-shaped, vasiform
the localized death of living cells (as from infection or the interruption of blood supply) (同)mortification, gangrene, sphacelus
toxic to the kidney

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
管状の,管から成る
壊疽(えそ)

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1. 急性腎障害（急性腎不全）における腎前性疾患および急性尿細管壊死の病因および診断 etiology and diagnosis of prerenal disease and acute tubular necrosis in acute kidney injury acute renal failure
2. アミノグリコシドによる腎毒性の症状および危険因子 manifestations of and risk factors for aminoglycoside nephrotoxicity
3. アミノグリコシドの腎毒性および聴覚毒性の病因および予防 pathogenesis and prevention of aminoglycoside nephrotoxicity and ototoxicity
4. 小児における急性腎障害：臨床的特徴、病因、評価、および診断 acute kidney injury in children clinical features etiology evaluation and diagnosis
5. 急性尿細管壊死後の腎臓および患者の転帰 renal and patient outcomes after acute tubular necrosis

Aulagnon F1, Lapidus N2, Canet E1, Galicier L3, Boutboul D3, Peraldi MN4, Reuter D1, Bernard R1, Schlemmer B1, Azoulay E1, Zafrani L5.
American journal of kidney diseases : the official journal of the National Kidney Foundation.Am J Kidney Dis.2015 Jun;65(6):851-9. doi: 10.1053/j.ajkd.2014.10.012. Epub 2014 Nov 4.
BACKGROUND: Acute kidney injury (AKI) in the setting of hemophagocytic lymphohistiocytosis (HLH) is poorly characterized. This study aims to describe the incidence, clinical and biological features, and outcome associated with AKI in this population.STUDY DESIGN: Case series.SETTING & PARTICIPAN
PMID 25480521

Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.

Vicente-Vicente L1, Sánchez-Juanes F2, García-Sánchez O3, Blanco-Gozalo V4, Pescador M3, Sevilla MA3, González-Buitrago JM5, López-Hernández FJ6, López-Novoa JM1, Morales AI7.
Toxicology letters.Toxicol Lett.2015 Apr 16;234(2):99-109. doi: 10.1016/j.toxlet.2014.11.033. Epub 2015 Feb 9.
Nephrotoxicity limits the therapeutic efficacy of the antineoplastic drug cisplatin. Due to dosage adjustment and appropriate monitoring, most therapeutic courses with cisplatin produce no or minimal kidney damage. However, we studied whether even sub-nephrotoxic dosage of cisplatin poses a potentia
PMID 25677510

Concomitant protective and therapeutic role of verapamil in chronic mercury induced nephrotoxicity in the adult rat: histological, morphometric and ultrastructural study.

Haleem NY1, El-Aasar HM1, Zaki SM1, Sabry SM1, El-Zainy AW1.
Archives of medical science : AMS.Arch Med Sci.2015 Mar 16;11(1):199-209. doi: 10.5114/aoms.2013.37342. Epub 2015 Mar 14.
INTRODUCTION: Mercury intoxication is a widespread problem as mercury is used in the manufacture of thermometers, batteries and electrical switches. It forms one of the most diffusible environmental pollutants. Mercury has a nephrotoxic effect which could occur at low exposure levels. Verapamil coul
PMID 25861308