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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/06 20:35:20」(JST)

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Nemonapride (Emilace) is an atypical antipsychotic approved in Japan for the treatment of schizophrenia. It was launched by Yamanouchi in 1991. Nemonapride acts as a D₂ and D₃ receptor antagonist, and is also a potent 5-HT_1A receptor agonist. It has affinity for sigma receptors.

References[edit]

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English Journal

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.

Moreno E1, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodríguez-Ruiz M, Medrano M, Mallol J, Cortés A, Casadó V, Lluís C, Ferré S, Ortiz J, Canela E, McCormick PJ.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2014 Mar 5;34(10):3545-58. doi: 10.1523/JNEUROSCI.4147-13.2014.
The general effects of cocaine are not well understood at the molecular level. What is known is that the dopamine D1 receptor plays an important role. Here we show that a key mechanism may be cocaine's blockade of the histamine H3 receptor-mediated inhibition of D1 receptor function. This blockade r
PMID 24599455

Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function.

Vinish M1, Elnabawi A, Milstein JA, Burke JS, Kallevang JK, Turek KC, Lansink CS, Merchenthaler I, Bailey AM, Kolb B, Cheer JF, Frost DO.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2013 Aug;16(7):1599-609. doi: 10.1017/S1461145712001642. Epub 2013 Jan 25.
Antipsychotic drugs are increasingly used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of early life antipsychotic drug (APD) treatment. Most APDs are potent antagonists or partial agonists of dopamine (DA) D₂ recepto
PMID 23351612

Central dopamine D2 receptors regulate growth-hormone-dependent body growth and pheromone signaling to conspecific males.

Noaín D1, Pérez-Millán MI, Bello EP, Luque GM, Casas Cordero R, Gelman DM, Peper M, Tornadu IG, Low MJ, Becú-Villalobos D, Rubinstein M.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2013 Mar 27;33(13):5834-42. doi: 10.1523/JNEUROSCI.5673-12.2013.
Competition between adult males for limited resources such as food and receptive females is shaped by the male pattern of pituitary growth hormone (GH) secretion that determines body size and the production of urinary pheromones involved in male-to-male aggression. In the brain, dopamine (DA) provid
PMID 23536095

Japanese Journal

Induction of larval metamorphosis in the sea cucumber Apostichopus japonicus by neurotransmitters

MATSUURA Hiroshi,YAZAKI Ikuko,OKINO Tatsufumi
Fisheries science : FS 75(3), 777-783, 2009-05-01
… However, the D2-like dopamine receptor antagonists sulpiride and nemonapride (10 μM) did not inhibit the effect of dopamine. …
NAID 10024971407

Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum : comparison of [^<11>C]raclopride, [^<11>C]nemonapride and [^<11>C]N-methylspiperone

ISHIWATA K
Nucl Med Biol 29(3), 307-316, 2002
NAID 30003368359

Related Pictures

★リンクテーブル★

リンク元	「ベンズアミド」「ネモナプリド」

「ベンズアミド」

Nemonapride
Systematic (IUPAC) name
	N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	75272-39-8
ATC code	None
PubChem	CID 4452
UNII	Q88T5P3444
KEGG	D01468
Chemical data
Formula	C21H26ClN3O2
Mol. mass	387.90 g/mol
	SMILES CC1C(CCN1CC2=CC=CC=C2)NC(=O)C3=CC(=C(C=C3OC)NC)Cl;
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