同: MHC＆graft rejection
関: graft rejection

WordNet

of your secondary field of academic concentration or specialization
limited in size or scope; "a small business"; "a newspaper with a modest circulation"; "small-scale plans"; "a pocket-size country" (同)modest, small, small-scale, pocket-size, pocket-sized
not of legal age; "minor children" (同)nonaged, underage
warranting only temporal punishment; "venial sin" (同)venial
inferior in number or size or amount; "a minor share of the profits"; "Ursa Minor"
lesser in scope or effect; "had minor differences"; "a minor disturbance"
of a scale or mode; "the minor keys"; "in B flat minor"
of lesser importance or stature or rank; "a minor poet"; "had a minor part in the play"; "a minor official"; "many of these hardy adventurers were minor noblemen"; "minor back roads"
of lesser seriousness or danger; "suffered only minor injuries"; "some minor flooding"; "a minor tropical disturbance"
of the younger of two boys with the same family name; "Jones minor"
any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
condition in which the cells of one tissue can survive in the presence of cells of another tissue; "a successful graft or transplant requires a high degree of histocompatibility"

PrepTutorEJDIC

『小さいほうの,少ない』 / (階級・地位・重要性などが)『劣ったほうの』,重要でない / 重大ではない / 未成年の / (音楽で)短調の / 未成年者 / (大学の科目・課程の)副専攻科目 / (音楽で)短調 / 《the minors》《米》=minor league
抗原(生物の体内にはいって免疫体を作る物質)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/17 00:40:25」(JST)

wiki en

Minor histocompatibility antigen (a.k.a. MHA) are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants.^[1] They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC).

Minor histocompatibility antigens are due to normal proteins that are in themselves polymorphic in a given population. Even when a transplant donor and recipient are identical with respect to their major histocompatibility complex genes, the amino acid differences in minor proteins can cause the grafted tissue to be slowly rejected.

Clinical implications

Immunization of mothers against male-specific minor histocompatibility (H-Y) antigens has a pathogenic role in many cases of secondary recurrent miscarriage, that is, recurrent miscarriage in pregnancies succeeding a previous live birth. An example of this effect is that the male:female ratio of children born prior and subsequent to secondary recurrent miscarriage is 1.49 and 0.76 respectively.^[2]

References

^ Robertson N, Chain J, Millrain M, Scott D, Hashim F, Mankteloner E, Lemonnier F, Simpson E, Dyson J (2007). "Natural regulation of immunity to minor histocompatibility antigens". J Immunol. 178 (6): 3558–65. doi:10.4049/jimmunol.178.6.3558. PMID 17339452.
^ Nielsen, H. S. (2011). "Secondary recurrent miscarriage and H-Y immunity". Human Reproduction Update. doi:10.1093/humupd/dmr005.

External links

Minor histocompatibility antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. 移植免疫 transplantation immunobiology
2. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
3. 移植片対宿主病の病因 pathogenesis of graft versus host disease
4. 造血細胞移植後の再発の予防および治療のための免疫療法 immunotherapy for the prevention and treatment of relapse following hematopoietic cell transplantation
5. 膜性腎症と腎移植 membranous nephropathy and renal transplantation

English Journal

Strategies for the Identification of T Cell-Recognized Tumor Antigens in Hematological Malignancies for Improved Graft-versus-Tumor Responses after Allogeneic Blood and Marrow Transplantation.

Zilberberg J1, Feinman R2, Korngold R2.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2015 Jun;21(6):1000-1007. doi: 10.1016/j.bbmt.2014.11.001. Epub 2014 Nov 20.
Allogeneic blood and marrow transplantation (allo-BMT) is an effective immunotherapeutic treatment that can provide partial or complete remission for patients with hematological malignancies. Mature donor T cells in the donor inoculum play a central role in mediating graft-versus-tumor (GVT) respons
PMID 25459643

Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans.

Nakasone H1, Tian L2, Sahaf B1, Kawase T3, Schoenrock K1, Perloff S1, Ryan CE1, Paul J1, Popli R1, Wu F1, Otani JM1, Coller J4, Warren EH 3rd3, Miklos DB1.
Blood.Blood.2015 May 14;125(20):3193-201. doi: 10.1182/blood-2014-11-613323. Epub 2015 Mar 12.
Allogeneic antibodies against minor histocompatibility antigens encoded on the Y chromosome (HY-Abs) develop after hematopoietic cell transplant (HCT) of male recipients with female donors (F→M). However, the temporal association between HY-Ab development and chronic graft-versus-host disease (cGV
PMID 25766725

siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8(+) T cells in NOD/SCID/IL2Rg(null) mice.

van der Waart AB1, Fredrix H, van der Voort R, Schaap N, Hobo W, Dolstra H.
Cancer immunology, immunotherapy : CII.Cancer Immunol Immunother.2015 May;64(5):645-54. doi: 10.1007/s00262-015-1668-6. Epub 2015 Feb 28.
Allogeneic stem cell transplantation (allo-SCT) can be a curative therapy for patients suffering from hematological malignancies. The therapeutic efficacy is based on donor-derived CD8(+) T cells that recognize minor histocompatibility antigens (MiHAs) expressed by patient's tumor cells. However, th
PMID 25724840

Japanese Journal

同種造血幹細胞移植とマイナー組織適合性抗原 (AYUMI HLAと疾患--最新トピックス)

医学のあゆみ 233(13), 1217-1222, 2010-06-26
NAID 40017154199

非血縁骨髄移植後の再発に対する臍帯血移植後に，第１ドナーリンパ球による移植片対白血病効果が認められたＴリンパ芽球性リンパ腫

臨床血液 51(6), 413-421, 2010
NAID 130004501401

Graft versus leukemia(GVL)効果の標的抗原

臨床免疫・アレルギー科 51(1), 83-89, 2009-01
NAID 40016464331

Related Pictures

Immunodominant minor histocompatibility antigens: the major ones: Immunology Today Brain Cells Difference Between Major and Minor Histocompatibility Antigens | Compare the Frontiers | Minor Histocompatibility Antigen-Specific T Cells | Pediatrics Histocompatibility Antigens; Transplantation Antigens Targeting minor histocompatibility antigens in graft versus tumor or graft versus