methylprednisolone sodium succinate

WordNet

1. a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

PrepTutorEJDIC

1. ソジウム,ナトリウム(金属元素;化学記号はNa)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/26 05:52:41」(JST)

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Methylprednisolone

Systematic (IUPAC) name
(1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Clinical data
Trade names	Medrol, Meprolone
AHFS/Drugs.com	monograph
MedlinePlus	a682795
Licence data	US FDA:link
Pregnancy cat.	A (AU) C (US)
Legal status	POM (UK) ℞-only (US)
Routes	IV, IM, IV Infusion, Oral, Rectal, Topical
Pharmacokinetic data
Protein binding	78%
Metabolism	liver primarily, kidney, tissues; CYP450: 3A4 substrate
Half-life	urine; Half-life: 18-26h (biological)
Identifiers
CAS number	83-43-2 Y
ATC code	D07AA01 D07AC14, D10AA02, H02AB04
PubChem	CID 6741
DrugBank	DB00959
ChemSpider	6485 Y
UNII	X4W7ZR7023 Y
KEGG	D00407 Y
ChEBI	CHEBI:6888 Y
ChEMBL	CHEMBL650 Y
Synonyms	(6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione
Chemical data
Formula	C22H30O5
Mol. mass	374.471 g/mol
SMILES O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](C)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)CC[C@@H]23)C)C
InChI InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1 Y Key:VHRSUDSXCMQTMA-PJHHCJLFSA-N Y
Y (what is this?)  (verify)

Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug. It is marketed in the USA and Canada under the brand names Medrol and Solu-Medrol. It is also available as a generic drug.

It is a variant of prednisolone, methylated at carbon 6 of the B ring.

Uses

Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory effects. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methylprednisolone is prescribed is rather long, and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used as a treatment for multiple sclerosis.

Methylprednisolone is also prescribed for nonpenetrating spinal cord injuries. It has been shown that a dose of 30 mg/kg IV followed by IV drip at 5.4 mg/kg/h for 23 hours improves sensory and motor recovery if given within eight hours of the injury.

It is also used for vestibular neuritis.

After egg retrieval for a cycle of in vitro fertilization, methylprednisolone may be prescribed to prevent the body from rejecting the embryos being transferred, up to the time of implantation.

Methylprednisolone may also be beneficial in the treatment of patients in cardiac arrest.

Side effects

Long-term use of methylprednisolone, as with all corticosteroids, can be associated with hyperglycemia, decreased resistance to infection, swelling of face, weight gain, congestive cardiac insufficiency, fluid and sodium retention, edema, hypertension, increased eye pressure, glaucoma, osteoporosis and psychosis, especially when used at high dosage. The most serious side effect occurs after the adrenal glands cease natural production of cortisol, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of tablets to take at designated times over a several-day period. Pharmacists sometimes advise that this drug can cause sleeplessness and "down" moods.

Individuals on methylprednisolone therapy should assiduously avoid exposure to measles and chicken pox as contracting these viral infections while on high dose corticosteroids can result in a potentially fatal viral course. Any accidental exposure to these viral infections by individuals uncertain of their immunity to chicken pox or measles should be reported immediately as prophylactic immunoglobulin therapy may be administered. Additionally, the administration of live, attenuated vaccines is contraindicated for individuals taking immunosuppressive doses of methylprednisolone. The exception to this rule is patients receiving complete corticosteroid replacement therapy, e.g., for Addison's disease, who may follow standard immunization protocols.

Additional images

• 4mg Methylprednisolone tablets by Sandoz

• Medrol
  32mg Methylprednisolone tablets by Pfizer

See also

• Guanacastepene A - also composed as C22H30O5
• Prednisone - also a corticosteroid
• Dexamethasone - also a corticosteroid

References

External links

• Medrol Prescribing Information Pfizer
• U.S. National Library of Medicine: Drug Information Portal - Methylprednisolone
• "methylprednisolone" at medicinenet.com

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• 4. 全身性ステロイドに対する過敏反応 hypersensitivity reactions to systemic glucocorticoids
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English Journal

• In vitro trans-scleral iontophoresis of methylprednisolone hemisuccinate with short application time and high drug concentration.

• Pescina S, Martini D, Santi P, Padula C, Murtomäki L, Nicoli S.SourceUniversity of Parma, Interdepartmental Center Biopharmanet-TEC, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
• International journal of pharmaceutics.Int J Pharm.2013 Jul 15;451(1-2):12-7. doi: 10.1016/j.ijpharm.2013.04.066. Epub 2013 Apr 27.
• Trans-scleral iontophoresis, i.e. the application of small electric current to enhance drug transport across sclera is an option for non-invasive delivery of corticosteroids to the posterior segment of the eye. In this paper, in vitro trans-scleral iontophoresis of methylprednisolone hemisuccinate w
• PMID 23628405

• Drug adsorption on bovine and porcine sclera studied with streaming potential.

• Murtomäki L, Vainikka T, Pescina S, Nicoli S.SourceAalto University, Department of Chemistry, Aalto FI-00076, Finland; University of Helsinki, Centre for Drug Research, Helsinki FI-00014, Finland. lasse.murtomaki@aalto.fi.
• Journal of pharmaceutical sciences.J Pharm Sci.2013 Jul;102(7):2264-72. doi: 10.1002/jps.23585. Epub 2013 May 10.
• The affinity of a drug to a biological membrane can affect the distribution and the availability of the active compound to its target. Adsorption is usually determined with in vitro distribution studies based on partitioning of the drug between buffer and tissue, which have limitations such as the h
• PMID 23666826

Japanese Journal

• 間質性肺炎合併肺癌に対する周術期ステロイドとシベレスタットの使用経験

• 大内 政嗣,井上 修平,尾崎 良智,藤田 琢也,手塚 則明,花岡 淳,寺本 晃治,北村 将司,橋本 雅之
• 日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 26(5), 490-497, 2012-07-15
• 特発性間質性肺炎（Idiopathic Interstitial Pneumonia：IIP）合併肺癌手術時に，術後急性増悪予防のためステロイドとシベレスタットナトリウムを使用した周術期管理を行い，その安全性と有用性を検討した．2005年1月から2010年12月までに手術を行ったIIP合併肺癌10例に対して麻酔導入直前と手術終了時にコハク酸メチルプレドニゾロンナトリウム250 mgを静脈内投与し， …
• NAID 10030500854

• Corticosteroids Were Effective for Preventing Immidiate Atrial Fibrillation Events in Patients with Pericardial Effusion Due to the Ablation

• Kajihara Kenta,Nakano Yukiko,Oda Noboru,Suenari Kazuyoshi,Makita Yuko,Tokuyama Takehito,Motoda Chikaaki,Fujiwara Mai,Kihara Yasuki,Yoshida Yukihiko,Sairaku Akinori
• Journal of Arrhythmia 27(Supplement), PJ1_015, 2011
• … We compared occurrence of immediate AF events in patients used oral NSAIDs only or NSAIDs and intravenous sodium methylprednisolone succinate given on the day of the procedure. …
• NAID 130002130525

Related Pictures

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★リンクテーブル★

リンク元	「メチルプレドニゾロン」「methylprednisolone aceponate」「methylprednisolone hemisuccinate」「methylprednisolone succinate」「A-Methapred」
関連記事	「succinate」「methylprednisolone」「sodium succinate」

「メチルプレドニゾロン」

　　[★]

英

methylprednisolone

化

酢酸メチルプレドニゾロン methylprednisolone acetate、アセトン酸メチルプレドニゾロン methylprednisolone aceponate、コハク酸メチルプレドニゾロンナトリウム methylprednisolone sodium succinate、]]、ヘミコハク酸メチルプレドニゾロン

関

糖質コルチコイド

種類

• メチルプレドニゾロン - (錠)メドロール、(軟膏)ネオメドロール
• 酢酸メチルプレドニゾロン - (注)デポ・メドロール
• コハク酸メチルプレドニゾロンナトリウム - (注)ソル・メドロール、(注)ソル・メルコート、(注)プリドール

「methylprednisolone aceponate」

　　[★]

アセ・ン酸メチルプレドニゾロン

関

methylprednisolone、methylprednisolone acetate、methylprednisolone sodium succinate

「methylprednisolone hemisuccinate」

　　[★]

ヘミコハク酸メチルプレドニゾロン

関

methylprednisolone sodium succinate、methylprednisolone succinate、Solumedrol

「methylprednisolone succinate」

　　[★]

コハク酸メチルプレドニゾロン

関

methylprednisolone hemisuccinate、methylprednisolone sodium succinate、Solumedrol

「A-Methapred」

　　[★]

同

methylprednisolone sodium succinate

「succinate」

　　[★] コハク酸、コハク酸塩、コハク酸エステル, succinic acid

「methylprednisolone」

　　[★] メチルプレドニゾロン

同

Depo-Medrol, Medrol, Solu- Medrol

「sodium succinate」

　　[★]

コハク酸ナトリウム