アセ・ン酸メチルプレドニゾロン
- 関
- methylprednisolone、methylprednisolone acetate、methylprednisolone sodium succinate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/05 10:58:44」(JST)
[Wiki en表示]
Methylprednisolone aceponate
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Clinical data |
AHFS/Drugs.com |
Consumer Drug Information |
Identifiers |
CAS Registry Number |
86401-95-8 Y |
ATC code |
D07AC14 |
PubChem |
CID: 63019 |
ChemSpider |
56717 N |
UNII |
ET54W9J4U2 N |
Chemical data |
Formula |
C27H36O7 |
Molecular mass |
472.571 |
SMILES
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CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C[C@@H](C4=CC(=O)C=C[C@]34C)C)O)C)C(=O)COC(=O)C
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InChI
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InChI=1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1 N
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Key:DALKLAYLIPSCQL-YPYQNWSCSA-N N
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N (what is this?) (verify) |
See also: methylprednisolone
Methylprednisolone aceponate is a glucocorticosteroid.[1]
See also
References
- ^ Bieber T, Vick K, Fölster-Holst R, et al. (February 2007). "Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis". Allergy 62 (2): 184–9. doi:10.1111/j.1398-9995.2006.01269.x. PMID 17298428.
Glucocorticoids and antiglucocorticoids (H02)
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Agonists |
Pregnene |
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Pregnenedione |
- Hydrocortisone (cortisol)# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- Halogenated at 6: Cloprednol
- Halogenated, with FG at 16: Halcinonide
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Pregnadiene |
- Rimexolone
- Halogenated, with FG at 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
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Pregnadienediol |
- Prednisone (Meprednisone)
- Halogenated at 9: Fluorometholone
- Halogenated, with FG at 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
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Pregnadienetriol |
- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- Halogenated: Fluprednisolone (Difluprednate
- Fluperolone)
- Halogenated, with FG at 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
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Pregnatriene |
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Androstene |
- Halogenated, with FG at 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
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Others/unsorted |
- Halogenated: Loteprednol
- Halogenated, with FG at 16: Fludroxycortide
- Formocortal
- Mometasone furoate
- Promestriene
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Antagonists /
SGRMs |
- Antagonists: Ketoconazole
- Mifepristone
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Synthesis modifiers |
- Acetoxolone
- Aminoglutethimide
- Carbenoxolone
- Enoxolone
- Ketoconazole
- Metyrapone
- Mitotane
- Trilostane
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of hormones
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Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
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Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
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Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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Glucocorticoid signaling
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Receptor
(ligands) |
GR
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Agonists
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Mixed (SEGRAs)
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- Dagrocorat
- Fosdagrocorat
- Mapracorat
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Antagonists
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- 3α-Hydroxytibolone
- 3β-Hydroxytibolone
- Aglepristone
- Asoprisnil
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Guggulsterone
- Ketoconazole
- Lilopristone
- LLY-2707
- Miconazole
- Mifepristone
- Onapristone
- Org 34850
- Pregnenolone 16α-carbonitrile
- Spironolactone
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
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Enzyme |
Modulators
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- See here instead (modulators of 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 11β-HSD, 21-hydroxylase, 11β-hydroxylase, and 18-hydroxylase).
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Others |
Precursors/prohormones
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- Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- Pregnenolone sulfate
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- 11-Deoxycorticosterone
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Indirect
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- ACTH (corticotropin)
- CRH
- DHEA
- DHEA sulfate
- Plasma proteins (albumin, transcortin)
- Vasopressin
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See also: Androgenics • Estrogenics • Mineralocorticoids • Progestogenics
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UpToDate Contents
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English Journal
- [Exudative onycholysis and acute bacterial paronychia related to BIBF-1120 and paclitaxel: response to topical therapy].
- Freites-Martínez A, Martinez-Sánchez D, de Pablo NP, Calderón-Komaromy A, Córdoba S, Burbujo J.
- Investigación clínica.Invest Clin.2014 Mar;55(1):55-60.
- A case of a 50 years-old breast cancer patient treated with weekly paclitaxel and BIBF 1120 is reported herein. At the end of the twelfth cycle of chemotherapy, the patient developed distal onycholysis with intense hyponychium serous exudates, pain and malodor in all her fingernails. It was treated
- PMID 24758102
- Treatment of male genital lichen sclerosus with clobetasol propionate and maintenance with either methylprednisolone aceponate or tacrolimus: a retrospective study.
- Kyriakou A1, Patsialas C, Patsatsi A, Sotiriadis D.
- The Journal of dermatological treatment.J Dermatolog Treat.2013 Dec;24(6):431-4. doi: 10.3109/09546634.2013.782385. Epub 2013 May 6.
- OBJECTIVE: To assess the efficacy of clobetasol propionate 0.05% cream in male patients suffering from genital lichen sclerosus (GLS), as well as the efficacy of methylprednisolone aceponate 0.1% cream and tacrolimus 0.1% ointment as maintenance therapy.METHODS: The study was conducted retrospective
- PMID 23472631
- Fast itch relief in an experimental model for methylprednisolone aceponate topical corticosteroid activity, based on allergic contact eczema to nickel sulphate.
- Curto L1, Carnero L, López-Aventin D, Traveria G, Roura G, Giménez-Arnau AM.
- Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2013 Nov 4. doi: 10.1111/jdv.12292. [Epub ahead of print]
- BACKGROUND: Topical corticosteroids (TC) consistently show effectiveness against itch, a paradigmatic symptom, in various eczemas. Rapid itch relief is a therapeutic goal. The early response of itch to TC has not been adequately studied.OBJECTIVES: To assess the effect on itch of a TC, methylprednis
- PMID 24612282
Japanese Journal
- Methylprednisolone Aceponate (ZK 91 588) の毒性研究(II), ラットにおける 14 週間反復投与毒性試験
- Anti-inflammatory, systemic and dermal atrophy activities in topical application of dermal methylprednisolone aceponate
- 合成副腎皮質ステロイドMethylprednisolone aceponateの抗炎症作用
- 生駒 幸弘 [他],山下 雅世,紙谷 清,中川 英彦
- 日本薬理学雑誌 98(5), 409-417, 1991
- … In the case of dermal application of the drugs to croton oil-induced ear edema in rats and picryl chlorideinduced delayed type hypersensitivity in mice, the anti-inflammatory effect of methylprednisolone aceponate (MPA) was slightly weaker than those of clobetasol 17-propionate and diflucortolone 21-valerate, but stronger than those of hydrocortisone 17-butyrate and hydrocortisone 17-butyrate 21propionate. …
- NAID 130000758814
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- Synopsis Methylprednisolone aceponate is a nonhalogenated diester of 6α-methylprednisolone which, based on its anti-inflammatory activity, has been classified as a potent glucocorticosteroid. In adults and children with various ...
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- 英
- methylprednisolone
- 化
- 酢酸メチルプレドニゾロン methylprednisolone acetate、アセトン酸メチルプレドニゾロン methylprednisolone aceponate、コハク酸メチルプレドニゾロンナトリウム methylprednisolone sodium succinate、]]、ヘミコハク酸メチルプレドニゾロン
- 関
- 糖質コルチコイド
種類
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- 英
- methylprednisolone aceponate
- 関
- メチルプレドニゾロン
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メチルプレドニゾロン
- 同
- Depo-Medrol, Medrol, Solu- Medrol