Methylergometrine
|
Systematic (IUPAC) name |
9,10-Didehydro-N-[1-(hydroxymethyl)-propyl]-D-lysergamide |
Clinical data |
Trade names |
Methergine |
AHFS/Drugs.com |
International Drug Names |
MedlinePlus |
a601077 |
Pregnancy cat. |
|
Legal status |
|
Routes |
Oral |
Pharmacokinetic data |
Metabolism |
Liver |
Half-life |
30–120 min |
Excretion |
Mostly bile |
Identifiers |
CAS number |
113-42-8 Y |
ATC code |
G02AB01 |
PubChem |
CID 8226 |
ChemSpider |
7933 N |
UNII |
W53L6FE61V N |
ChEMBL |
CHEMBL1201356 N |
Synonyms |
Methylergobasine
Methylergobrevin
Methylergonovine |
Chemical data |
Formula |
C20H25N3O2 |
Mol. mass |
339.432 g/mol |
SMILES
- CC[C@@H](CO)NC(=O)[C@@H]2/C=C1/c3cccc4N\C=C(\C[C@H]1N(C)C2)c34
|
InChI
-
InChI=1S/C20H25N3O2/c1-3-14(11-24)22-20(25)13-7-16-15-5-4-6-17-19(15)12(9-21-17)8-18(16)23(2)10-13/h4-7,9,13-14,18,21,24H,3,8,10-11H2,1-2H3,(H,22,25)/t13-,14+,18-/m1/s1 N
Key:UNBRKDKAWYKMIV-QWQRMKEZSA-N N
|
Physical data |
Melt. point |
172 °C (342 °F) |
Solubility in water |
insoluble mg/mL (20 °C) |
N (what is this?) (verify) |
Methylergometrine (other names include methylergonovine, methylergobasin, methergine, and D-lysergic acid 1-butanolamide) is a synthetic analogue of ergonovine, a psychedelic alkaloid found in ergot, and many species of morning glory. It is a member of the ergoline family and chemically similar to LSD, ergine, ergometrine, and lysergic acid. Due to its oxytocic properties, it has a medical use in obstetrics. According to Jonathan Ott, methylergonovine has LSD-like actions above 2 milligrams[citation needed]. Clinical dosages are ten times lower.
Methylergometrine maleate is marketed under the trade name Methergine.
Contents
- 1 Uses
- 1.1 Obstetric use
- 1.2 Migraine
- 2 Contraindications
- 3 Side effects
- 4 Interactions
- 5 Mechanism of action
- 6 References
Uses
Obstetric use
Methylergometrine is a smooth muscle constrictor that mostly acts on the uterus. It is most commonly used to prevent or control excessive bleeding following childbirth and spontaneous or elective abortion, and also to aid in expulsion of retained products of conception after a missed abortion (miscarriage in which all or part of the fetus remains in the uterus) and to help deliver the placenta after childbirth. It is available as tablets or injection (IM or IV) or in liquid form to be taken orally.[1][2][3]
Migraine
Methylergometrine is sometimes used for both prevention[4] and acute treatment[5] of migraine. It is an active metabolite of methysergide.
Contraindications
Methylergometrine is contraindicated in patients with hypertension and preeclampsia, and also during pregnancy and birth.[1]
Side effects
Adverse effects include:[1]
- Cholinergic effects such as nausea, vomiting, and diarrhea
- Dizziness
- Pulmonary hypertension[citation needed]
- Coronary artery vasoconstriction
- Severe systemic hypertension (especially in patients with preeclampsia)
- Convulsions
In excessive doses, methylergometrine can also lead to cramping, respiratory depression and coma.[1]
Interactions
Methylergometrine likely interacts with drugs that inhibit the liver enzyme CYP3A4, such as azole antifungals, macrolide antibiotics and many HIV drugs. It can also increase constriction of blood vessels caused by sympathomimetic drugs and other ergot alkaloids.[1]
Mechanism of action
Methylergometrine is a partial agonist/antagonist on serotonergic, dopaminergic and alpha-adrenergic receptors. Its specific binding and activation pattern on these receptors leads to a highly, if not completely, specific contraction of smooth uterus muscle via 5-HT2A serotonin receptors,[6] while blood vessels are affected to a lesser extent compared to other ergot alkaloids.[1]
References
- ^ a b c d e f Jasek, W, ed. (2007). Austria-Codex (in German) (62nd ed.). Vienna: Österreichischer Apothekerverlag. pp. 5193–5. ISBN 978-3-85200-181-4.
- ^ Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 447. ISBN 3-8047-1763-2.
- ^ Fachinformation des Arzneimittel-Kompendium der Schweiz: Methergin (German)
- ^ Koehler, PJ; Tfelt-Hansen PC (Nov 2008). "History of methysergide in migraine.". Cephalalgia 28 (11): 1126–35. doi:10.1111/j.1468-2982.2008.01648.x. PMID 18644039. Retrieved 11 December 2011.
- ^ Niño-Maldonado, Alfredo; Gary Caballero-García; Wilfrido Mercado-Bochero; Fernando Rico-Villademoros; Elena P Calandre (8 Nov 2009). "Efficacy and tolerability of intravenous methylergonovine in migraine female patients attending the emergency department: a pilot open-label study". Head Face Med 5 (21). doi:10.1186/1746-160X-5-21. PMC 2780385. PMID 19895705.
- ^ Heinz Pertz, Eckart Eich (1999). "Ergot alkaloids and their derivatives as ligands for serotoninergic, dopaminergic and adrenergic receptors". In Vladimír Křen,Ladislav Cvak. Ergot: the genus Claviceps. CRC Press. pp. 411–440. ISBN 978-905702375-0.
Uterotonics/labor inducers/oxytocics (G02A)
|
|
Cervical ripening |
Ergot alkaloids
|
- Ergometrine# (+oxytocin)
- Methylergometrine
|
|
Prostaglandins and
analogues
|
- E: Misoprostol/E1#
- Gemeprost/E1
- Dinoprostone/E2
- Sulprostone/E2
- F: Dinoprost/F2α
- Carboprost/F2α
|
|
|
Contraction induction |
- Oxytocin#
- Carbetocin
- Demoxytocin
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
|
Hallucinogens
|
|
Psychedelics
5-HT2AR agonists |
Lysergamides
|
- AL-LAD
- ALD-52
- BU-LAD
- IP-LAD
- Diallyllysergamide
- Dimethyllysergamide
- Ergometrine
- ETH-LAD
- LAE-32
- LPD-824
- LSA
- LSD
- LSD-Pip
- LSH
- LSM-775
- Lysergic acid 2-butyl amide
- LSZ
- Lysergic acid 3-pentyl amide
- Methylergometrine
- Methylisopropyllysergamide
- Methysergide
- N1-Methyl-lysergic acid diethylamide
- PARGY-LAD
- PRO-LAD
|
|
Phenethylamines
|
|
|
Piperazines
|
|
|
Tryptamines
|
- 1-Methyl-5-methoxy-diisopropyltryptamine
- 2,N,N-TMT
- 4,5-DHP-AMT
- 4,5-DHP-DMT
- 4-Acetoxy-DALT
- 4-Acetoxy-DET
- 4-Acetoxy-DiPT
- 4-Acetoxy-DMT
- 4-Acetoxy-DPT
- 4-Acetoxy-MiPT
- 4-HO-5-MeO-DMT
- 4-HO-DBT
- 4-HO-DPT
- 4-HO-MET
- 4-HO-MPMI
- 4-HO-MPT
- 4,N,N-TMT
- 4-Propionyloxy-DMT
- 5,6-diBr-DMT
- 5-AcO-DMT
- 5-Bromo-DMT
- 5-Me-MIPT
- 5-MeO-2,N,N-TMT
- 5-MeO-4,N,N-TMT
- 5-MeO-α,N,N-TMT
- 5-MeO-α-ET
- 5-MeO-α-MT
- 5-MeO-DALT
- 5-MeO-DET
- 5-MeO-DiPT
- 5-MeO-DMT
- 5-MeO-DPT
- 5-MeO-EiPT
- 5-MeO-MET
- 5-MeO-MiPT
- 5-MeO-MPMI
- 5-N,N-TMT
- 7,N,N-TMT
- α-ET
- α-MT
- α,N,N-TMT
- Aeruginascin
- Baeocystin
- Bufotenin
- DALT
- DBT
- DCPT
- DET
- DIPT
- DMT
- DPT
- EiPT
- Ethocin
- Ethocybin
- Ibogaine
- Iprocin
- MET
- Miprocin
- MiPT
- Norbaeocystin
- Noribogaine
- PiPT
- Psilocin
- Psilocybin
- Voacangine
|
|
Others
|
- AL-38022A
- ALPHA
- Efavirenz
- Elemicin
- M-ALPHA
- Myristicin
- RH-34
|
|
|
Dissociatives
NMDAR antagonists |
Adamantanes
|
- Amantadine
- Memantine
- Rimantadine
|
|
Arylcyclohexylamines
|
- 3-MeO-PCP
- 4-MeO-PCP
- Dieticyclidine
- Diphenidine
- Esketamine
- Ethketamine
- Eticyclidine
- Gacyclidine
- Ketamine
- Methoxetamine
- Methoxyketamine
- Neramexane
- PCPr
- Phencyclidine
- Rolicyclidine
- Tenocyclidine
- Tiletamine
|
|
Morphinans
|
- Dextrallorphan
- Dextromethorphan
- Dextrorphan
- Racemethorphan
- Racemorphan
|
|
Others
|
- 2-MDP
- 8A-PDHQ
- Aptiganel
- Dexoxadrol
- Dizocilpine
- Etoxadrol
- Ibogaine
- Midafotel
- NEFA
- Nitrous oxide
- Noribogaine
- Perzinfotel
- Remacemide
- Selfotel
- Xenon
|
|
|
Deliriants
mAChR antagonists |
- 3-Quinuclidinyl benzilate
- Atropine
- Benactyzine
- Benzatropine
- Benzydamine
- Biperiden
- BRN-1484501
- Brompheniramine
- CAR-226,086
- CAR-301,060
- CAR-302,196
- CAR-302,282
- CAR-302,368
- CAR-302,537
- CAR-302,668
- Chloropyramine
- Chlorphenamine
- Clemastine
- CS-27349
- Cyclizine
- Cyproheptadine
- Dicycloverine
- Dimenhydrinate
- Diphenhydramine
- Ditran
- Doxylamine
- EA-3167
- EA-3443
- EA-3580
- EA-3834
- Flavoxate
- Hyoscyamine
- Meclozine
- Mepyramine
- N-Ethyl-3-piperidyl benzilate
- N-Methyl-3-piperidyl benzilate
- Orphenadrine
- Oxybutynin
- Pheniramine
- Phenyltoloxamine
- Procyclidine
- Promethazine
- Scopolamine
- Tolterodine
- Trihexyphenidyl
- Tripelennamine
- Triprolidine
- WIN-2299
|
|
Miscellaneous |
Cannabinoids
CB1R agonists
|
Phytocannabinoids
|
- Cannabinol
- THC (Dronabinol)
- THCV
- (Cannabidiol has different mechanism of action)
|
|
Synthetic
|
- 4-HTMPIPO
- 5F-PB-22
- AB-001
- AB-005
- A-836,339
- AB-CHMINACA
- AB-FUBINACA
- AB-PINACA
- ADB-FUBINACA
- ADB-PINACA
- ADBICA
- AM-630
- AM-679
- AM-694
- AM-1220
- AM-1221
- AM-1235
- AM-1241
- AM-1248
- AM-2201
- AM-2232
- AM-2233
- APICA
- APINACA
- CB-13
- CP 47,497
- CP 55,244
- CP 55,940
- DMHP
- HU-210
- HU-308
- JWH-007
- JWH-015
- JWH-018
- JWH-019
- JWH-030
- JWH-073
- JWH-081
- JWH-098
- JWH-116
- JWH-122
- JWH-149
- JWH-167
- JWH-182
- JWH-193
- JWH-198
- JWH-200
- JWH-203
- JWH-210
- JWH-250
- JWH-251
- JWH-398
- JWH-424
- JTE 7-31
- JTE-907
- Levonantradol
- MAM-2201
- MDA-19
- MN-25
- NESS-0327
- NESS-040C5
- Nabilone
- Nabitan
- Org 28611
- Parahexyl
- QUCHIC
- QUPIC
- RCS-4
- RCS-8
- SDB-006
- STS-135
- THC-O-acetate
- THC-O-phosphate
- UR-144
- WIN 55,212-2
- XLR-11
|
|
|
D2R agonists
|
- Apomorphine
- Aporphine
- Bromocriptine
- Cabergoline
- Lisuride
- Memantine
- Nuciferine
- Pergolide
- Piribedil
- Pramipexole
- Ropinirole
- Rotigotine
Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, methamphetamine), and precursors (levodopa).
|
|
GABAAR agonists
|
- Eszopiclone
- Gaboxadol
- Ibotenic acid
- Muscimol
- Zaleplon
- Zolpidem
- Zopiclone
|
|
Inhalants
Mixed MOA
|
- Aliphatic hydrocarbons
- Butane
- Gasoline
- Kerosene
- Propane
- Aromatic hydrocarbons
- Ethers
- Haloalkanes
- Chlorofluorocarbons
- Chloroform
|
|
κOR agonists
|
- 2-EMSB
- 2-MMSB
- Alazocine
- Bremazocine
- Butorphanol
- Cyclazocine
- Cyprenorphine
- Dextrallorphan
- Dezocine
- Enadoline
- Herkinorin
- HZ-2
- Ibogaine
- Ketazocine
- LPK-26
- Metazocine
- Nalbuphine
- Nalorphine
- Noribogaine
- Pentazocine
- Phenazocine
- Salvinorin A
- Spiradoline
- Tifluadom
- U-50488
- U-69,593
|
|
MAO inhibitors
|
- Harmaline
- Harmine
- Tetrahydroharmine
- Yohimbine
|
|
σR agonists
|
- DMT
- Dextrallorphan
- Dextromethorphan
- Dextrorphan
- Noscapine
|
|
Others
|
- Glaucine
- Isoaminile
- Pukateine
|
|
|