mRNA開裂および・リアデニル化因子

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
(embryology) the repeated division of a fertilised ovum (同)segmentation
the breaking of a chemical bond in a molecule resulting in smaller molecules
the state of being split or cleft; "there was a cleavage between the liberal and conservative members"
the act of cleaving or splitting
the line formed by a groove between two parts (especially the separation between a womans breasts)
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
割る(割れる)こと;割れ(裂け)目 / 卵割(受精卵の細胞分裂) / (鉱物の結晶の)劈開(へきかい) / 《話》(大きなえりぐりのドレスから見える)乳房の谷間
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
(次にくる語の発音が母音で始まるときに用いる) / (子音[h]で始まり第1音節に強勢のない語の場合はanを用いることがある.ただし,この場合は[h]を発音しない)

UpToDate Contents

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English Journal

Chemical shift assignments of a new folded domain from yeast Pcf11.

Xu X1,2, Pérébaskine N1,2, Minvielle-Sébastia L1,2, Fribourg S1,2, Mackereth CD3,4.
Biomolecular NMR assignments.Biomol NMR Assign.2015 Oct;9(2):421-5. doi: 10.1007/s12104-015-9622-2. Epub 2015 Jul 2.
The yeast protein Pcf11 is a component of the cleavage/polyadenylation factor IA (CF IA) complex involved in the 3' processing of pre-mRNA. Pcf11 interacts with RNA and the C-terminal domain (CTD) of the largest subunit of RNA polymerase II via the CTD-interaction domain (CID), and other peptide reg
PMID 26133941

NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation.

Gennarino VA1, Alcott CE2, Chen CA1, Chaudhury A3, Gillentine MA1, Rosenfeld JA1, Parikh S4, Wheless JW5, Roeder ER1, Horovitz DD6, Roney EK1, Smith JL1, Cheung SW1, Li W7, Neilson JR3, Schaaf CP1, Zoghbi HY1.
eLife.Elife.2015 Aug 27;4. doi: 10.7554/eLife.10782.
The brain is sensitive to the dose of MeCP2 such that small fluctuations in protein quantity lead to neuropsychiatric disease. Despite the importance of MeCP2 levels to brain function, little is known about its regulation. In this study, we report eleven individuals with neuropsychiatric disease and
PMID 26312503

Amino acid residues Leu135 and Tyr236 are required for RNA binding activity of CFIm25 in Entamoeba histolytica.

Ospina-Villa JD1, Zamorano-Carrillo A2, Lopez-Camarillo C3, Castañon-Sanchez CA4, Soto-Sanchez J5, Ramirez-Moreno E2, Marchat LA6.
Biochimie.Biochimie.2015 Aug;115:44-51. doi: 10.1016/j.biochi.2015.04.017. Epub 2015 May 2.
Pre-mRNA 3' end processing in the nucleus is essential for mRNA stability, efficient nuclear transport, and translation in eukaryotic cells. In Human, the cleavage/polyadenylation machinery contains the 25 kDa subunit of the Cleavage Factor Im (CFIm25), which specifically recognizes two UGUA elemen
PMID 25941172