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of or relating to or produced by lymph
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood

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リンパ[液]の / (人が)不活発な,鈍重な
白血病

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/11 02:14:12」(JST)

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Lymphoid leukemia or lymphocytic leukemia is a type of leukemia affecting circulating lymphocyte cells. This is in contrast to lymphoma, which is a solid tumor of the same type of cells.^[1]

Lymphocytes are a subtype of white blood cells. Most lymphoid leukemias involve a particular subtype of lymphocytes, the B cell.

Classification

Historically, they have been most commonly divided by the stage of maturation at which the clonal (neoplastic) lymphoid population stopped maturing:

Acute lymphoblastic leukemia
Chronic lymphocytic leukemia

However, the influential WHO Classification (published in 2001) emphasized a greater emphasis on cell lineage. To this end, lymphoid leukemias can also be divided by the type of cells affected:

B-cell leukemia
T-cell leukemia
NK-cell leukemia

The most common type of lymphoid leukemia is B-cell chronic lymphocytic leukemia.

B-cell leukemias

B-cell leukemia describes several different types of lymphoid leukemia which affect B cells.

Comparison of most common B-cell leukemias	Incidence	Histopathology	Cell markers	Comments
B-cell chronic lymphocytic leukemia (ICD-O: 9823/3)	30% of all leukemias. Also 3 to 4% of lymphomas in adults^[2]	Small resting lymphocytes mixed with variable number of large activated cells. Lymph nodes are diffusely effaced^[2]	CD5, surface immunoglobulin^[2]	Occurs in older adults. Usually involves lymph nodes, bone marrow and spleen. Most patients have peripheral blood involvement. Indolent.^[2]
Precursor B-cell lymphoblastic leukemia (ICD-O: 9835/3-9836/3)	85% of acute leukemias in childhood,^[2] Less common in adults^[2]	Lymphoblasts with irregular nuclear contours, condensed chromatin, small nucleoli and scant cytoplasm without granules.^[2]	TdT, CD19^[2]	Usually presents as acute leukemia^[2]

Other types include (with ICD-O code):

9826/3 - Acute lymphoblastic leukemia, mature B-cell type
9833/3 - B-cell prolymphocytic leukemia
9940/3 - Hairy cell leukemia

T-cell leukemias

T-cell leukemia describes several different types of lymphoid leukemias which affect T cells.

The most common T-cell leukemia is precursor T-cell lymphoblastic leukemia.^[2] It causes 15% of acute leukemias in childhood, and also 40% of lymphomas in childhood.^[2] It is most common in adolescent males.^[2] Its morphology is identical to that of precursor B-cell lymphoblastic leukemia.^[2] Cell markers include TdT, CD2, CD7.^[2] It often presents as a mediastinal mass because of involvement of the thymus.^[2] It is highly associated with NOTCH1 mutations.^[2]

Other types include:

Large granular lymphocytic leukemia
Adult T-cell leukemia/lymphoma
T-cell prolymphocytic leukemia

In practice, it can be hard to distinguish T-cell leukemia from T-cell lymphoma, and they are often grouped together.

References

^ Parham, Peter (2005). The immune system. New York: Garland Science. p. 414. ISBN 0-8153-4093-1.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p Table 12-8 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.

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English Journal

ZGDHu-1 promotes apoptosis of chronic lymphocytic leukemia cells.

Qiu LN, Zhou YL, Wang ZN, Huang Q, Hu WX.SourceCentre of Laboratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou 310014, P.R. China.
International journal of oncology.Int J Oncol.2012 Aug;41(2):533-40. doi: 10.3892/ijo.2012.1467. Epub 2012 May 8.
Chronic lymphocytic leukemia (CLL) is a low-grade lymphoid malignancy incurable with conventional modalities of chemotherapy. We aimed to examine the proapoptotic effects of a novel proteasome inhibitor, N,N'-di-(m-methylphenyi)-3,6- dimethyl-1,4-dihydro-1,2,4,5-tetrazine-1,4
PMID 22581170

Cytogenetic profile of 1,863 Ph/BCR-ABL-positive chronic myelogenous leukemia patients from the Chinese population.

Mu Q, Ma Q, Wang Y, Chen Z, Tong X, Chen FF, Lu Y, Jin J.SourceDepartment of Hematology & Institute of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, No.79 Qingchun Road, Hangzhou, 310003, Zhejiang, People's Republic of China.
Annals of hematology.Ann Hematol.2012 Jul;91(7):1065-72. Epub 2012 Feb 15.
Cytogenetic analyses of chronic myelogenous leukemia (CML) have been performed previously in a large number of reports, but systematical research based on large sample sizes from the Chinese population is seldom available. In this study, we analyzed the cytogenetic profiles of 1,863 Philadelphia (Ph
PMID 22349721

Japanese Journal

Successful Extracorporeal Life Support for Life-threatening Hypercapnia with Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation

Waseda Koichi,Tanimoto Yasushi,Ichiba Shingo,Miyahara Nobuaki,Murakami Toshi,Ochi Nobuaki,Terado Michihisa,Nagano Osamu,Maeda Yoshinobu,Kanehiro Arihiko,Ujike Yoshihito,Tanimoto Mitsune
Acta Medica Okayama 65(6), 403-406, 2011-12
… We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. …
NAID 80022180813

Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia : a retrospective safety analysis

KOBAYASHI Yukio,SAKAMAKI Hisashi,FUJISAWA Shin,ANDO Kiyoshi,YAMAMOTO Kazuhito,OKADA Masaya,ISHIZAWA Kenichi,NAGAI Tadashi,MIYAWAKI Syuichi,MOTOJI Toshiko,USUI Noriko,IIDA Shinsuke,TANIWAKI Masafumi,UOSHIMA Nobuhiko,SERIU Taku,OHNO Ryuzo
International journal of hematology 93(6), 745-749, 2011-06-01
NAID 10029535516