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any of several forms of ulcerative skin disease
a constellation in the southern hemisphere near Centaurus

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狼瘡(ろうそう)(皮膚結核の一種)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/06 10:57:22」(JST)

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Lupus erythematosus is a category for a collection of diseases with similar underlying problems with immunity (autoimmune disease).^[1] Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. Four main types of lupus exist: systemic lupus erythematosus, discoid lupus erythematosus, drug-induced lupus erythematosus, and neonatal lupus erythematosus. Of these, systemic lupus erythematosus (also known as SLE) is the most common and serious form of lupus.

Lupus is an autoimmune disease where the body's immune system becomes hyperactive and attacks normal, healthy tissue. When the body's immune system is operating normally it produces antibodies to fight viruses and bacteria and other antigens. Lupus makes the antibodies created unable to differentiate between antigens and healthy tissue causing the antibodies to attack healthy tissue. Resulting symptoms include inflammation, swelling, damage to joints, skin, kidneys, blood, heart and lungs.

Photosensitivity's relationship to and influence on the systemic manifestations of lupus remain to be defined. Mechanisms for photosensitivity might include: modulation of autoantibody location, cytotoxic effects, apoptosis induction with autoantigens in apoptotic blebs, upregulation of adhesion molecules and cytokines, induction of nitric oxide synthase expression and ultraviolet-generated antigenic DNA. Tumor necrosis factor alpha also seems to play a role in the development of photosensitivity.^[2]

Types

Lupus erythematosus may manifest as a systemic disease or in purely cutaneous forms. Types of lupus erythematosus can be categorized into the following types:^[3]^[4]

Acute cutaneous lupus erythematosus
Subacute cutaneous lupus erythematosus
Chronic cutaneous lupus erythematosus
- Discoid lupus erythematosus
  - Childhood discoid lupus erythematosus
  - Generalized discoid lupus erythematosus
  - Localized discoid lupus erythematosus
- Chilblain lupus erythematosus (Hutchinson)
- Lupus erythematosus-lichen planus overlap syndrome
- Lupus erythematosus panniculitis (Lupus erythematosus profundus)
- Tumid lupus erythematosus
- Verrucous lupus erythematosus (Hypertrophic lupus erythematosus)
Complement deficiency syndromes
Drug-induced lupus erythematosus
Neonatal lupus erythematosus
Systemic lupus erythematosus

References

^ Fitzpatrick, Thomas B.; Klauss Wolff; Wolff, Klaus Dieter; Johnson, Richard R.; Suurmond, Dick; Richard Suurmond (2005). Fitzpatrick's color atlas and synopsis of clinical dermatology. New York: McGraw-Hill Medical Pub. Division. ISBN 0-07-144019-4.
^ Scheinfeld NS, Deleo V. Photosensitivity in lupus erythematosus. Photodermatol Photoimmunol Photomed. 2004;20:272-9. PMID 15379880
^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Chapter 8. ISBN 0-7216-2921-0.
^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.

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1. 成人における全身性エリテマトーデスの臨床症状の概要 overview of the clinical manifestations of systemic lupus erythematosus in adults
2. 成人における全身性エリテマトーデスの治療および予後の概要 overview of the therapy and prognosis of systemic lupus erythematosus in adults
3. 成人における全身性エリテマトーデスの診断および鑑別診断 diagnosis and differential diagnosis of systemic lupus erythematosus in adults
4. 全身性エリテマトーデスの皮膚粘膜症状 mucocutaneous manifestations of systemic lupus erythematosus
5. 小児における全身性エリテマトーデス systemic lupus erythematosus in children

English Journal

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis among Mexicans.

Topete-Reyes JF, Soto-Vargas J, Morán-Moguel MC, Dávalos-Rodríguez IP, Chávez-González EL, García-de la Torre I, Parra-Michel R, Medina-Pérez M, Jalomo-Martínez B, Salazar-Páramo M.SourceDoctorado en Inmunología, Departamento de Fisiología, CUCS, Universidad de Guadalajara , Guadalajara , Mexico.
Immunopharmacology and immunotoxicology.Immunopharmacol Immunotoxicol.2013 Feb;35(1):174-80. doi: 10.3109/08923973.2012.739175.
The angiotensin (Ang)-converting enzyme (ACE) insertion/deletion (I/D) polymorphism determines Ang II levels, but its relationship with lupus nephritis (LN) in different populations is controversial. Objective: To describe the allelic and genotypic distribution of the I/D polymorphism in Mexican m
PMID 23137230

Membrane-Bound Complement Regulatory Proteins as Biomarkers and Potential Therapeutic Targets for SLE.

Das N, Biswas B, Khera R.SourceDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India, nibhriti@hotmail.com.
Advances in experimental medicine and biology.Adv Exp Med Biol.2013;734:55-81.
For the last two decades, there had been remarkable advancement in understanding the role of complement regulatory proteins in autoimmune disorders and importance of complement inhibitors as therapeutics. Systemic lupus erythematosus is a prototype of systemic autoimmune disorders. The disease, thou
PMID 22990695

Japanese Journal

SLE治療中に発症した若年外陰癌の1例

神奈川産科婦人科学会誌 = Kanagawa journal of obstetrics and gynecology : official journal, Kanagawa Society of Obstetrics and Gynecology 52(1), 6-9, 2015-09
NAID 40020623562

成人発症Still病を中心とした膠原病による頸部リンパ節腫脹 (特集見逃されやすい頸部リンパ節腫脹の原因疾患)

血液内科 = Hematology 71(3), 348-351, 2015-09
NAID 40020613524

全身性エリテマトーデスおよび悪性リンパ腫の治療中に発症した偽膜を伴う潰瘍性アスペルギルス気管気管支炎

京都府立医科大学雑誌 124(9), 623-630, 2015-09
NAID 40020609329

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★リンクテーブル★

リンク元	「エリテマトーデス」「紅斑性狼蒼」「紅斑性狼瘡」「LE」
拡張検索	「discoid lupus erythematosus」「neonatal lupus erythematosus」「cutaneous lupus erythematosus」「chronic discoid lupus erythematosus」
関連記事	「erythematosus」「lupus」