レシチン・コレステロールアシルトランスフェラーゼ
WordNet
- a yellow phospholipid essential for the metabolism of fats; found in egg yolk and in many plant and animal cells; used commercially as an emulsifier
- an animal sterol that is normally synthesized by the liver; the most abundant steroid in animal tissues (同)cholesterin
PrepTutorEJDIC
- レシチン(神経細胞や卵黄などに含まれるリン脂質)
- コレステロール(胆汁・血液・神経組織などの脂肪性成分)
UpToDate Contents
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English Journal
- Impact of apolipoprotein A1- or lecithin:cholesterol acyltransferase-deficiency on white adipose tissue metabolic activity and glucose homeostasis in mice.
- Xepapadaki E, Maulucci G, Constantinou C, Karavia EA, Zvintzou E, Daniel B, Sasson S, Kypreos KE.
- Biochimica et biophysica acta. Molecular basis of disease. 2019 Jun;1865(6)1351-1360.
- High density lipoprotein (HDL) has attracted the attention of biomedical community due to its well-documented role in atheroprotection. HDL has also been recently implicated in the regulation of islets of Langerhans secretory function and in the etiology of peripheral insulin sensitivity. Indeed, da
- PMID 30742993
- The P274S Mutation of Lecithin-Cholesterol Acyltransferase (LCAT) and Its Clinical Manifestations in a Large Kindred.
- Fountoulakis N, Lioudaki E, Lygerou D, Dermitzaki EK, Papakitsou I, Kounali V, Holleboom AG, Stratigis S, Belogianni C, Syngelaki P, Stratakis S, Evangeliou A, Gakiopoulou H, Kuivenhoven JA, Wevers R, Dafnis E, Stylianou K.
- American journal of kidney diseases : the official journal of the National Kidney Foundation. 2019 May;().
- Lecithin-cholesterol acyltransferase (LCAT) catalyzes the maturation of high-density lipoprotein. Homozygosity for loss-of-function mutations causes familial LCAT deficiency (FLD), characterized by corneal opacities, anemia, and renal involvement. This study sought to characterize kidney biopsy find
- PMID 31103331
- Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation.
- Tsujita M, Akita N, Yokota T, Kobayashi F, Yokoyama S.
- Journal of atherosclerosis and thrombosis. 2019 May;().
- Probucol is a controversial drug to inhibit ATP-binding cassette transporter A1 (ABCA1) and to exhibit some positive clinical effects such as regression of xanthomas. It reportedly rescues female infertility in scavenger receptor BI-deficient mice. Here, we investigated the effect of probucol on pro
- PMID 31092744
Japanese Journal
- 病気について知りたい! 臨床講座(43)脂質異常症
Related Links
- The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma. Lecithin:cholesterol acyltransfer ... In addition to its function in HDL metabolism, LCAT has also long ...
- Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme that catalyzes the esterification of free cholesterol in plasma lipoproteins and plays a critical role in high-density lipoprotein (HDL) metabolism. Deficiency leads to ...
★リンクテーブル★
[★]
- 英
- lecithin-cholesterol acyltransferase, lecithin cholesterol acyltransferase, LCAT, lecithin:cholesterol acyltransferase
- 同
- レシチンコレステロールアシルトランスフェラーゼ
[show details]
産生臓器
局在
機能
コレステロールエステルの運命
- HDLのコレステロールエステルはCETPによりIDL、LDLに受け渡され、肝臓に逆輸送される
臨床関連
[★]
アシルトランスフェラーゼ、アシル転移酵素、アシル基転移酵素
- 関
- transacylase
[★]
コレステロール