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the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system

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carbonの化学記号
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/31 21:07:20」(JST)

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Lanatoside C (or isolanid) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally^[1] or by the intravenous route.^[2] It is marketed in a number of countries and is also available in generic form.^[3] Its main indications are rapid response atrial fibrilation and paroxysmal supraventricular tachycardia,^{[citation needed]} two common types of arrhythmia.

It is found in Digitalis lanata.^[4]

Chemistry

The substance is composed of four monosaccharides (glucose, 3-acetyldigitoxose and two digitoxoses) and an aglycon named digoxigenin.^[5]

References

^ Lypka, A.; Lazowski, J. (1979). "(title in Polish)" [Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]. Wiadomości Lekarskie (in Polish) (Warsaw, Poland) 32 (18): 1277–1281. PMID 506267. edit
^ Tàmmaro, A. E.; Baldoli, C. (1967). "On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects" [On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]. La Clinica Terapeutica (in Italian) 40 (2): 157–161. PMID 5600177. edit
^ "Lanatoside C". International Drug Names. Drugs.com.
^ Determination of Lanatoside C and Digoxin in Digitalis lanata by Hplc and Its Application to Analysis of the Fermented Leaf Powder. Yukari Ikeda, Youichi Fujii and Mitsuru Yamazaki, J. Nat. Prod., 1992, volume 55, issue 6, pages 748–752, doi:10.1021/np50084a007
^ Desai, U. R. (2005). "Cardiac Glycosides". VCU School of Pharmacy.

UpToDate Contents

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1. ジギタリス（強心配糖体）中毒 digitalis cardiac glycoside poisoning

English Journal

Screening approach by ultra-high performance liquid chromatography-tandem mass spectrometry for the blood quantification of thirty-four toxic principles of plant origin. Application to forensic toxicology.

Carlier J1, Guitton J2, Romeuf L3, Bévalot F4, Boyer B5, Fanton L6, Gaillard Y3.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2015 Jan 15;975:65-76. doi: 10.1016/j.jchromb.2014.10.028. Epub 2014 Nov 1.
Plant poisonings have left their mark on history and still cause many deaths, whether intentional or accidental. The means to show toxicological evidence of such poisonings should be implemented with great care. This article presents a technique for measuring thirty-nine toxic principles of plant or
PMID 25438245

Antiviral activity of lanatoside C against dengue virus infection.

Cheung YY1, Chen KC1, Chen H1, Seng EK2, Chu JJ3.
Antiviral research.Antiviral Res.2014 Nov;111:93-9. doi: 10.1016/j.antiviral.2014.09.007. Epub 2014 Sep 22.
Dengue infection poses a serious threat globally due to its recent rapid spread and rise in incidence. Currently, there is no approved vaccine or effective antiviral drug for dengue virus infection. In response to the urgent need for the development of an effective antiviral for dengue virus, the US
PMID 25251726

Hydrogen peroxide-induced antioxidant activities and cardiotonic glycoside accumulation in callus cultures of endemic Digitalis species.

Cingoz GS1, Verma SK2, Gurel E2.
Plant physiology and biochemistry : PPB / Société française de physiologie végétale.Plant Physiol Biochem.2014 Sep;82:89-94. doi: 10.1016/j.plaphy.2014.05.008. Epub 2014 May 28.
The effect of hydrogen peroxide (H2O2) on callus cultures of four Digitalis species (Digitalis lamarckii, Digitalis trojana, Digitalis davisiana and Digitalis cariensis) increased catalase (CAT), superoxide dismutase (SOD), total phenolic, proline activity and cardiotonic glycoside production. Callu
PMID 24915111

Japanese Journal

39 有機触媒による糖類の位置選択的アシル化 : 配糖体天然物の位置選択的全合成並びに官能基化(口頭発表の部)

天然有機化合物討論会講演要旨集 (53), 229-234, 2011-09-02
NAID 110009986540

Cloning and Functional Expression in Escherichia coli of a cDNA Encoding Cardenolide 16'-O-Glucohydrolase from Digitalis lanata Ehrh.

Plant and cell physiology 41(11), 1293-1298, 2000-11
NAID 10006232058

High-performance liquid chromatography-ionspray mass spectrometry for the specific determination of digoxin and some related cardiac glycosides in human plasma

Journal of chromatography. B, Biomedical sciences and applications 692(1), 101-109, 1997-04-25
NAID 10024514196

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リンク元	「ラナトシドC」
関連記事	「C」「Cs」「Cd」「c」

「ラナトシドC」

Lanatoside C
Systematic (IUPAC) name
	(3β,5β,12β)- 3-{[β-D- glucopyranosyl- (1→4)- 3-O-acetyl- 2,6-dideoxy- β-D-ribo- hexopyranosyl- (1→4)- 2,6-dideoxy- β-D- ribo- hexopyranosyl- (1→4)- 2,6-dideoxy- β-D- ribo- hexopyranosyl]oxy}- 12,14-dihydroxycard- 20(22)- enolide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Routes	Oral, intravenous
Identifiers
CAS number	17575-22-3
ATC code	C01AA06
PubChem	CID 656630
ChemSpider	570984
UNII	5RR3JFZ771
KEGG	D01972
ChEMBL	CHEMBL506569
Synonyms	[6-[6-[6-[[12,14-dihydroxy- 10,13-dimethyl- 17-(5-oxo-2H-furan-3-yl)- 1,2,3,4,5,6,7,8,9,11,12,15,16,17- tetradecahydrocyclopenta[a]phenanthren- 3-yl]oxy]- 4-hydroxy- 2-methyloxan- 3-yl]oxy- 4-hydroxy- 2-methyloxan-3-yl]oxy- 2-methyl- 3-[3,4,5-trihydroxy- 6-(hydroxymethyl)oxan-2-yl]oxyoxan- 4-yl] acetate
Chemical data
Formula	C49H76O20
Mol. mass	985.116 g/mol
	SMILES C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]4[C@@H]3C[C@H]([C@]5([C@@]4(CC[C@@H]5C6=CC(=O)OC6)O)C)O)C)O)O[C@H]7C[C@@H]([C@@H]([C@H](O7)C)O[C@H]8C[C@@H]([C@@H]([C@H](O8)C)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O)OC(=O)C)O;
	InChI InChI=1S/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29-,30+,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1 ; Key:JAYAGJDXJIDEKI-PTGWOZRBSA-N ;
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