Variation in general practice prostate-specific antigen testing and prostate cancer outcomes: an ecological study.
Hjertholm P1, Fenger-Grøn M, Vestergaard M, Christensen MB, Borre M, Møller H, Vedsted P.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jan 15;136(2):435-42. doi: 10.1002/ijc.29008. Epub 2014 Jun 12.
Knowledge is sparse about the consequences of variation in prostate-specific antigen (PSA) testing rates in general practice. This study investigated associations between PSA testing and prostate cancer- related outcomes in Danish general practice, where screening for prostate cancer is not recommen
Synthesis, biological evaluation, and docking studies of PAR2-AP-derived pseudopeptides as inhibitors of kallikrein 5 and 6.
Severino B, Fiorino F, Corvino A, Caliendo G, Santagada V, Assis DM, Oliveira JR, Juliano L, Manganelli S, Benfenati E, Frecentese F, Perissutti E, Juliano MA.
Biological chemistry.Biol Chem.2015 Jan 1;396(1):45-52. doi: 10.1515/hsz-2014-0190.
Abstract A series of protease activated receptor 2 activating peptide (PAR2-AP) derivatives (1-15) were designed and synthesized. The obtained compounds were tested on a panel of human kallikreins (hKLK1, hKLK2, hKLK5, hKLK6, and hKLK7) and were found completely inactive toward hKLK1, hKLK2, and hKL
Toward the First Class of Suicide Inhibitors of Kallikreins Involved in Skin Diseases.
Tan X1, Soualmia F, Furio L, Renard J, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A, Reboud-Ravaux M.
Journal of medicinal chemistry.J Med Chem.2014 Dec 22. [Epub ahead of print]
The inhibition of kallikreins 5 and 7, and possibly kallikrein 14 and matriptase, (that initiates the kallikrein proteolytic cascade) constitutes an innovative way to treat some skin diseases such as Netherton syndrome. We present here the inhibitory properties of coumarin-3-carboxylate derivatives
Extractability from capsule or tablet preparations, and quality test were examined on 5 commercial kalliginogenase products. In extraction from tablet or capsule preparations, we ground them to powder with a small amount of water in ...