イプリフラボン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/16 20:19:01」(JST)
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Ipriflavone
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| Systematic (IUPAC) name |
| 7-isopropoxy-3-phenyl-4H-chromen-4-one |
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Legal status |
? |
| Identifiers |
| CAS number |
35212-22-7 N |
| ATC code |
M05BX01 |
| PubChem |
CID 3747 |
| UNII |
80BJ7WN25Z Y |
| KEGG |
D01338 Y |
| ChEMBL |
CHEMBL165790 N |
| Synonyms |
3-phenyl-7-propan-2-yloxychromen-4-one |
| Chemical data |
| Formula |
C18H16O3 |
| Mol. mass |
280.318 g/mol |
| N (what is this?) (verify) |
Ipriflavone is a synthetic isoflavone which may be used to inhibit bone resorption,[1] maintain bone density and to prevent osteoporosis in postmenopausal women. It is not used to treat osteoporosis. It slows down the action of the osteoclasts (bone-eroding cells), possibly allowing the osteoblasts (bone-building cells) to build up bone mass.
A clinical trial reported in 2001 that it was not effective in prevention or treatment of osteoporosis.[2]
A double-blind study reveals that ipriflavone might be effective on reducing tinnitus on otosclerosis sufferers.[3]
References[edit]
- ^ Civitelli, R. (1997). "In Vitro and in Vivo effects of ipriflavone on bone formation and bone biomechanics". Calcified Tissue International 61: S12–4. doi:10.1007/s002239900378 . PMID 9263610.
- ^ Alexandersen, P.; Toussaint, A; Christiansen, C; Devogelaer, JP; Roux, C; Fechtenbaum, J; Gennari, C; Reginster, JY; Ipriflavone Multicenter European Fracture Study (2001). "Ipriflavone in the Treatment of Postmenopausal Osteoporosis: A Randomized Controlled Trial". JAMA 285 (11): 1482–8. doi:10.1001/jama.285.11.1482 . PMID 11255425.
- ^ Sziklai, I; Komora, V; Ribári, O (1992). "Double-blind study on the effectiveness of a bioflavonoid in the control of tinnitus in otosclerosis". Acta chirurgica Hungarica 33 (1–2): 101–7. PMID 1343452.
External links[edit]
- Ipriflavone at PDR Health
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Drugs for treatment of bone diseases (M05)
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| Bisphosphonates |
- Nitrogenous (Alendronic acid
- ibandronic acid
- incadronic acid
- pamidronic acid
- risedronic acid
- zoledronic acid)
Non-nitrogenous (Etidronic acid
- clodronic acid
- tiludronic acid)
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| Bone morphogenetic proteins |
- Dibotermin alfa
- Eptotermin alfa
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| Other |
- Resorption inhibitor (Ipriflavone)
- Aluminium chlorohydrate
- Dual action bone agent (Strontium ranelate)
RANKL inhibitor (Denosumab)- Cathepsin K inhibitor (Odanacatib)
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anat (c/f/k/f, u, t/p, l)/phys/devp/cell
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noco/cong/tumr, sysi/epon, injr
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Isoflavones and their glycosides
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| Isoflavones |
- Daidzein
- Genistein
- Irilone
- Orobol
- Pseudobaptigenin
- Anagyroidisoflavone A and B
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| O-methylated isoflavones |
- Biochanin A
- Calycosin
- Formononetin
- Glycitein
- Irigenin
- 5-O-methylgenistein
- Pratensein
- Prunetin
- Psi-tectorigenin
- Retusin
- Tectorigenin
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| Glycosides |
- Daidzin
- Genistin
- Iridin
- Ononin
- Puerarin
- Sophoricoside
- Tectoridin
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| Prenylated isoflavones |
- Bidwillol A
- Derrubone
- Luteone
- 7-O-Methylluteone
- Wighteone
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| Pyranoisoflavones |
- Alpinumisoflavone
- Barbigerone
- Di-O-methylalpinumisoflavone
- 4'-methyl-alpinumisoflavone
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| Misc |
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| Synthetic |
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UpToDate Contents
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English Journal
- Low hygroscopic spray-dried powders with trans-glycosylated food additives enhance the solubility and oral bioavailability of ipriflavone.
- Fujimori M1, Kadota K1, Kato K2, Seto Y2, Onoue S2, Sato H1, Ueda H3, Tozuka Y4.
- Food chemistry.Food Chem.2016 Jan 1;190:1050-5. doi: 10.1016/j.foodchem.2015.06.081. Epub 2015 Jun 23.
- The improvement in the solubility and dissolution rate may promote a superior absorption property towards the human body. The spray-dried powders (SDPs) of ipriflavone, which was used as a model hydrophobic flavone, with trans-glycosylated rutin (Rutin-G) showed the highest solubilizing effect of ip
- PMID 26213075
- Add-back therapy with GnRH analogues for uterine fibroids.
- Moroni RM1, Martins WP, Ferriani RA, Vieira CS, Nastri CO, Candido Dos Reis FJ, Brito LG.
- The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2015 Mar 20;3:CD010854. doi: 10.1002/14651858.CD010854.pub2.
- BACKGROUND: Uterine fibroids (also known as leiomyomas) are the most common benign pelvic tumours among women. They may be asymptomatic, or may be associated with pelvic symptoms such as bleeding and pain. Medical treatment of this condition is limited and gonadotropin-releasing hormone (GnRH) analo
- PMID 25793972
- Flavonoids enhance melanogenesis in human melanoma cells.
- Takekoshi S1, Nagata H, Kitatani K.
- The Tokai journal of experimental and clinical medicine.Tokai J Exp Clin Med.2014 Sep 20;39(3):116-21.
- Flavonoids are pigmentary compounds existing widely in plants. We have reported that quercetin (3, 3', 4', 5, 7-pentahydroxylflavone), one of the typical flavonoids, strongly promotes melanogenesis by melanocytes. Meanwhile, there are 8000 or more flavonoids having a chemical structure different fro
- PMID 25248426
Japanese Journal
- Evaluation of the Micellization Mechanism of an Amphipathic Graft Copolymer with Enhanced Solubility of Ipriflavone
- マウス乳癌,子宮腺筋症および脛骨骨密度に与えるイプリフラボンの影響
- 難水溶性製剤の溶出試験に界面活性剤として使用されるラウリル硫酸ナトリウムの品質に関する研究(第1報)
Related Links
- Ipriflavone is LIKELY SAFE for most people when used with proper medical supervision. It can cause side effects such as stomach pain, diarrhea, or dizziness. There is some concern that ipriflavone can cause a decreased white cell ...
- Ipriflavone is a synthetic flavonoid derived from the soy isoflavone called daidzein. It promotes the incorporation of calcium into bone and inhibits bone breakdown, thus preventing and reversing osteoporosis. Many clinical trials ...
★リンクテーブル★
[★]
- 英
- ipriflavone
- 商
- アスオスト、アンブジール、イバナシン、イプリプラスト、イプリフラボン、オステン、コバステン、サイポリン、フィオランス、フラボステン、ムービニン、モンタルジー
- 関
- イソフラボン、フラボノイド、ムラサキウマゴヤシ
概念
- 牧草ムラサキウマゴヤシに含まれるフラボノイドであるイソフラボン誘導体の1つ。
作用
- 骨吸収抑制作用：直接的な骨吸収抑制作用、及びエストロゲンのカルシトニン分泌促進作用を増強。
- 実験的骨粗鬆症モデル動物における骨量減少を抑制することが認められている。
適応
添付文書
- http://www.info.pmda.go.jp/go/pack/3999008F1273_1_06/3999008F1273_1_06?view=body