WordNet

a nucleoside that is formed by the deamination of adenosine; used in kidney transplantation to provide a temporary source of sugar

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/27 01:09:54」(JST)

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Inosine triphosphate (ITP) is an intermediate in the purine metabolism pathway, seen in the synthesis of ATP and GTP. It comprises an inosine nucleotide containing three phosphate groups esterified to the sugar moiety.

Disease relevance

chronic immune thrombocytopenic purpura in monozygotic twins: genetic factors predisposing to ITP.
helicobacter pylori and chronic ITP: the discrepancy in the clinical responses to eradication therapy might be due to differences in the bacterial strains.
severe hemoalysis following administration of Rh(o)(D)immune globulin in an ITP patient associated with anti-C.

References

Laster, A.J.; Conley, C.L.; Kickler, T.S.; Dorsch, C.A.; Bias, W.B. (9 December 1982). "Chronic immune thrombocytopenic purpura in monozygotic twins: genetic factors predisposing to ITP". New England Journal of Medicine. 307 (24): 1495. doi:10.1056/NEJM198212093072406. PMID 6890627.
Kekomaki, R.; Dawson, B.; McFarland, J.; Kunicki, T.J. (September 1991). "Localization of human platelet autoantigens to the cysteine-rich region of glycoprotein IIIa". Journal of Clinical Investigation. 88 (3): 847. doi:10.1172/JCI115386. PMID 1715887.
Takahashi, T.; Yujiri, T.; Tanizawa, Y. (2004). "Helicobacter pylori and chronic ITP: the discrepancy in the clinical responses to eradication therapy might be due to differences in the bacterial strains". Blood. 104 (2): 594. doi:10.1182/blood-2004-02-0702. PMID 15231581.
Schwartz, J.; Spitalnik, S.; Grima, K.M. (2006). "Severe hemolysis following administration of Rho(D) immune globulin in an ITP patient associated with anti-C". Blood. 107 (6): 2585. doi:10.1182/blood-2005-09-3854. PMID 16517982.
Dodd, P.M.; McCaffrey, J.A.; Hilton, S.; Mazumdar, M.; Herr, H.; Kelly, W.K.; Icasiano, E.; Boyle, M.G.; Bajorin, D.F. (February 2000). "Phase I evaluation of sequential doxorubicin gemcitabine then ifosfamide paclitaxel cisplatin for patients with unresectable or metastatic transitional-cell carcinoma of the urothelial tract". Journal of Clinical Oncology. doi:10.1200/jco.2000.18.4.840.

UpToDate Contents

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English Journal

The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury.

Roberts V1, Campbell DJ, Lu B, Chia J, Cowan PJ, Dwyer KM.
Transplantation.Transplantation.2017 Jul;101(7):e194-e204. doi: 10.1097/TP.0000000000001679.
PMID 28198766

ITPA activity in adults and children treated with or without azathioprine: relationship between TPMT activity, thiopurine metabolites and co-medications.

Roselyne B1, Citterio-Quentin A, Moulsma M, Gustin MP.
Therapeutic drug monitoring.Ther Drug Monit.2017 Jun 22. doi: 10.1097/FTD.0000000000000430. [Epub ahead of print]
PMID 28650902

The role of microorganisms in the degradation of adenosine triphosphate (ATP) in chill-stored common carp (Cyprinus carpio) fillets.

Li D1, Zhang L1, Song S1, Wang Z1, Kong C1, Luo Y2.
Food chemistry.Food Chem.2017 Jun 1;224:347-352. doi: 10.1016/j.foodchem.2016.12.056. Epub 2016 Dec 21.
PMID 28159278

Japanese Journal

ニトロソ化ストレスによるイノシン三リン酸の生成と細胞応答 (特集活性酸素シグナル制御とレドックスホメオスタシス)

作見邦彦,土本大介,中別府雄作
細胞工学 31(2), 175-180, 2012
NAID 40019159287

Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs

Jung Yoon Suk,Cheon Jae Hee,Park Jae Jun [他],MOON Chang Mo,KIM Eun Soo,LEE Jin Ha,KIM Seung Won,KIM Jae Hak,HONG Sung Pil,KIM Tae Il,KIM Won Ho
Journal of human genetics 55(2), 121-123, 2010-02-01
NAID 10030733780

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment

UCHIYAMA KAN,NAKAMURA MAKOTO,KUBOTA TAKAHIRO,YAMANE TATEKI,FUJISE KIYOTAKA,TAJIRI HISAO
Journal of gastroenterology 44(3), 197-203, 2009-03-01
NAID 10025173737

★リンクテーブル★

リンク元	「ITP」「イノシン三リン酸」
関連記事	「triphosphate」

「ITP」

Inosine triphosphate
Names
	IUPAC name (((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl)methoxy-hydroxyphosphoryl) phosphono hydrogen phosphate
	Other names iniosine triphosphate
Identifiers
3D model (JSmol)	Interactive image;
PubChem CID	8583;
	InChI Key: HAEJPQIATWHALX-KQYNXXCUSA-N ;
	SMILES C1=NC(=O)C2=C(N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O ;
Properties
Chemical formula	C10H15N4O14P3
Molar mass	508.17 g·mol−1
Solubility in water	903.5 mg/mL
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references