WordNet

(botany) either of the two parts of a bilabiate corolla or calyx
either the outer margin or the inner margin of the aperture of a gastropods shell
either of two fleshy folds of tissue that surround the mouth and play a role in speaking
not yet finished; "his thesis is still incomplete"; "an uncompleted play" (同)uncompleted
not complete or total; not completed; "an incomplete account of his life"; "political consequences of incomplete military success"; "an incomplete forward pass" (同)uncomplete
having one or more incisions reaching nearly to the midrib (同)dissected
a split or indentation in something (as the palate or chin)
a musical notation written on a staff indicating the pitch of the notes following it
Chinese distance measure; approximately 0.5 kilometers

PrepTutorEJDIC

〈C〉『くちびる』,口もと / 《複数形で》(発音器官としての)くちびる,口 / 〈U〉《俗》生意気な言葉 / 〈C〉(容器などの)口,へり,縁;(峡谷・火山などの)口 / 〈C〉(植物の)唇弁(しんべん)
不完全な;未完成の
cleaveの過去・過去分詞 / (地面・岩などの)裂け目,割れ目,ひび
(楽譜の五線上の最初に付ける)音部記号

UpToDate Contents

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1. 口唇口蓋裂の病因、出生前診断、産科マネージメント、および再発 etiology prenatal diagnosis obstetrical management and recurrence of orofacial clefts
2. 血管輪 vascular rings
3. 顔面裂および全前脳胞症 facial clefts and holoprosencephaly
4. 遺伝性皮膚症 the genodermatoses
5. 新生児における哺乳障害および嚥下障害 sucking and swallowing disorders in the newborn

English Journal

Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis.

Kurosaka H, Iulianella A, Williams T, Trainor PA.AbstractCleft lip, which results from impaired facial process growth and fusion, is one of the most common craniofacial birth defects. Many genes are known to be involved in the etiology of this disorder; however, our understanding of cleft lip pathogenesis remains incomplete. In the present study, we uncovered a role for sonic hedgehog (SHH) signaling during lip fusion. Mice carrying compound mutations in hedgehog acyltransferase (Hhat) and patched1 (Ptch1) exhibited perturbations in the SHH gradient during frontonasal development, which led to hypoplastic nasal process outgrowth, epithelial seam persistence, and cleft lip. Further investigation revealed that enhanced SHH signaling restricts canonical WNT signaling in the lambdoidal region by promoting expression of genes encoding WNT inhibitors. Moreover, reduction of canonical WNT signaling perturbed p63/interferon regulatory factor 6 (p63/IRF6) signaling, resulting in increased proliferation and decreased cell death, which was followed by persistence of the epithelial seam and cleft lip. Consistent with our results, mutations in genes that disrupt SHH and WNT signaling have been identified in both mice and humans with cleft lip. Collectively, our data illustrate that altered SHH signaling contributes to the etiology and pathogenesis of cleft lip through antagonistic interactions with other gene regulatory networks, including the canonical WNT and p63/IRF6 signaling pathways.
The Journal of clinical investigation.J Clin Invest.2014 Mar 3. pii: 72688. doi: 10.1172/JCI72688. [Epub ahead of print]
Cleft lip, which results from impaired facial process growth and fusion, is one of the most common craniofacial birth defects. Many genes are known to be involved in the etiology of this disorder; however, our understanding of cleft lip pathogenesis remains incomplete. In the present study, we uncov
PMID 24590292

Oral-facial-digital syndrome type I: Surgical approach and a case report.

González MG1, Castro MP2, Nieto DV2, Bouzán JC2.Author information 1Hospital Materno Infantil Teresa Herrera A Coruña, Complejo Hospitalario Universitario de A Coruña, Coruña, Spain. Electronic address: Mir_milenio@hotmail.com.2Hospital Materno Infantil Teresa Herrera A Coruña, Complejo Hospitalario Universitario de A Coruña, Coruña, Spain.AbstractPURPOSE: Oral-facial-digital (OFD) syndromes constitute a heterogeneous group of embrionary development disorders. There are at least 11 different forms, with a broad spectrum of clinical features, causing an important problem with the diagnosis. There are only a few reports in the recent literature, and there is no surgical technique described for its correction.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS.J Plast Reconstr Aesthet Surg.2014 Mar;67(3):396-8. doi: 10.1016/j.bjps.2013.06.044. Epub 2013 Jul 22.
PURPOSE: Oral-facial-digital (OFD) syndromes constitute a heterogeneous group of embrionary development disorders. There are at least 11 different forms, with a broad spectrum of clinical features, causing an important problem with the diagnosis. There are only a few reports in the recent literature
PMID 23886557

Successful Management Permitting Delayed Operative Revision of Cleft Palate in a Labrador Retriever.

Davidson AP1, Gregory C2, Dedrick P3.Author information 1Veterinary Medical Teaching Hospital Small Animal Clinic, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA 95616, USA; Pet Care Veterinary Hospital, East Campus, 2425 Mendocino Avenue, Santa Rosa, CA 95403, USA. Electronic address: apdavidson@ucdavis.edu.2Pet Care Veterinary Hospital, East Campus, 2425 Mendocino Avenue, Santa Rosa, CA 95403, USA.3Dedrick Veterinary Services, 1515 Refugio Road, Santa Ynez, CA 93460, USA.AbstractCongenital palate defects (CP) occur in dogs. Secondary cleft palate (SCP) is a congenital oronasal fistula resulting in incomplete closure of the hard and soft palate. SCP occurs alone or in combination with primary cleft palate involving the lip and premaxilla. CP results from incomplete fusion of the palatine shelves, most critical at 25 to 28 days gestation. Methods to improve survival of puppies with CP are sought by clients. This case report illustrates a successful method to manage nutrition in affected dogs until adult size is attained, facilitating surgical correction.
The Veterinary clinics of North America. Small animal practice.Vet Clin North Am Small Anim Pract.2014 Mar;44(2):325-329. doi: 10.1016/j.cvsm.2013.11.002. Epub 2013 Dec 10.
Congenital palate defects (CP) occur in dogs. Secondary cleft palate (SCP) is a congenital oronasal fistula resulting in incomplete closure of the hard and soft palate. SCP occurs alone or in combination with primary cleft palate involving the lip and premaxilla. CP results from incomplete fusion of
PMID 24580993