最初期タンパク質、前初期タンパク質
WordNet
- very young; "at an early age"
- before the usual time or the time expected; "she graduated early"; "the house was completed ahead of time" (同)ahead of time, too soon
- in good time; "he awoke betimes that morning" (同)betimes
- belonging to the distant past; "the early inhabitants of Europe"; "former generations"; "in other times" (同)former, other
- at or near the beginning of a period of time or course of events or before the usual or expected time; "early morning"; "an early warning"; "early diagnosis"; "an early death"; "took early retirement"; "an early spring"; "early varieties of peas and tomatoes mature before most standard varieties"
- being or occurring at an early stage of development; "in an early stage"; "early forms of life"; "early man"; "an early computer"
- expected in the near future; "look for an early end to the negotiations"
- of an early stage in the development of a language or literature; "the Early Hebrew alphabetical script is that used mainly from the 11th to the 6th centuries B.C."; "Early Modern English is represented in documents printed from 1476 to 1700"
- of the present time and place; "the immediate revisions"
- performed with little or no delay; "an immediate reply to my letter"; "a prompt reply"; "was quick to respond"; "a straightaway denial" (同)prompt, quick, straightaway
- having no intervening medium; "an immediate influence"
- immediately before or after as in a chain of cause and effect; "the immediate result"; "the immediate cause of the trouble"
- fruiting spike of a cereal plant especially corn (同)spike, capitulum
- attention to what is said; "he tried to get her ear"
- good hearing; "he had a keen ear"; "a good ear for pitch"
- the sense organ for hearing and equilibrium
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- a British peer ranking below a marquess and above a viscount
PrepTutorEJDIC
- (時間・時期が)『早い』,『初期の』 / 昔の / (普通より,予定より)早い / 近い将来の / (時間・時期的に)『早く』 / (予定・ふだんより)早く
- 『即座の』,即時の / 当座の,当面の / (時間・空間的に)すぐ近くの / 直接の,じかの(direct)
- 〈C〉『耳』 / 《単数形で》『聴覚』,聴力,音感 / 《単数形で》じっと聞くこと,傾聴 / 〈C〉耳の形をした物
- (麦・とうもろこしなどの)穂
- 蛋白(たんばく)質
- (英国の)伯爵
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/22 01:57:38」(JST)
[Wiki en表示]
For the airport with IATA code IEG, see Zielona Góra Airport.
Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli. They represent a standing response mechanism that is activated at the transcription level in the first round of response to stimuli, before any new proteins are synthesized. Thus IEGs are distinct from "late response" genes, which can only be activated later, following the synthesis of early response gene products. Thus IEGs have been called the "gateway to the genomic response". The term can describe viral regulatory proteins that are synthesized following viral infection of a host cell, or cellular proteins that are made immediately following stimulation of a resting cell by extracellular signals.
About 40 cellular IEGs have been identified so far. The earliest known and best characterized include c-fos, c-myc and c-jun, genes that were found to be homologous to retroviral oncogenes. Thus IEGs are well known as early regulators of cell growth and differentiation signals. However, other findings suggest roles for IEGs in many other cellular processes.
In their role as "gateways to genomic response", many IEG products are naturally transcription factors or other DNA-binding proteins. However, other important classes of IEG products include secreted proteins, cytoskeletal proteins, and receptor subunits.
Some IEGs such as zif268 and Arc have been implicated in learning and memory and long-term potentiation.[1][2]
External links
- Activation of Immediate Early Genes by Drugs of Abuse a monograph published by the National Institute on Drug Abuse
- Immediate-Early Genes at the US National Library of Medicine Medical Subject Headings (MeSH)
- Immediate-Early Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ^ Davis S, Bozon B, Laroche S (2003). "How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning?". Behav Brain Res 142 (1-2): 17–30. doi:10.1016/S0166-4328(02)00421-7. PMID 12798262.
- ^ Plath N, Ohana O, Dammermann B, Errington ML, Schmitz D, Gross C, Mao X, Engelsberg A, Mahike C, Welzi H, Kobalz U, Stawrakakis A, Fernandez E, Walteriet R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bosl MR, Lipp HP, Grant SGN, Bliss TVP, Wolfer DP, Kuhl D (2006). “Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.” Neuron. 52:437-444.
UpToDate Contents
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English Journal
- Full trans-activation mediated by the immediate-early protein of equine herpesvirus 1 requires a consensus TATA box, but not its cognate binding sequence.
- Kim SK1, Shakya AK2, O'Callaghan DJ2.
- Virus research.Virus Res.2016 Jan 4;211:222-32. doi: 10.1016/j.virusres.2015.10.026. Epub 2015 Nov 2.
- The immediate-early protein (IEP) of equine herpesvirus 1 (EHV-1) has extensive homology to the IEP of alphaherpesviruses and possesses domains essential for trans-activation, including an acidic trans-activation domain (TAD) and binding domains for DNA, TFIIB, and TBP. Our data showed that the IEP
- PMID 26541315
- A simple plasmid-based transient gene expression method using High Five cells.
- Shen X1, Pitol AK1, Bachmann V1, Hacker DL2, Baldi L1, Wurm FM3.
- Journal of biotechnology.J Biotechnol.2015 Dec 20;216:67-75. doi: 10.1016/j.jbiotec.2015.10.007. Epub 2015 Oct 23.
- The High Five (H5) cell line, derived from the lepidopteran Trichoplusia ni, is one of the major insect cell hosts for the production of recombinant proteins using the baculovirus expression vector system (BEVS). Here, we describe a simple polyethylenimine (PEI)-based transient gene expression (TGE)
- PMID 26476358
- AMPK Deficiency Blocks the Hypoxic Ventilatory Response and Thus Precipitates Hypoventilation and Apnea.
- Mahmoud AD1, Lewis S2, Juričić L3, Udoh UA4, Hartmann S5, Jansen MA6, Ogunbayo OA7, Puggioni P8, Holmes AP9, Kumar P10, Navarro-Dorado J11, Foretz M12, Viollet B13, Dutia MB14, Marshall I15, Evans AM16.
- American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2015 Dec 15. [Epub ahead of print]
- RATIONALE: Modulation of breathing by hypoxia accommodates variations in oxygen demand and supply during, for example, sleep and ascent to altitude, yet the precise molecular mechanisms remain controversial. Among those genes influenced by natural selection in high-altitude populations is that for t
- PMID 26669206
Japanese Journal
- Isolation and characterization of formaldehyde-responsive genes from golden pothos (Epipremnum aureum)
- TADA Yuichi,MATSUZAKI Tomoya,TANAKA Yuya
- Plant biotechnology 27(4), 325-331, 2010-09-25
- … We focused on the immediate-early response genes following formaldehyde treatment. … Two full length cDNA sequences corresponding to a putative class II chitinase and a hypothetical novel protein, which we termed DEG2, were generated by rapid amplification of cDNA ends (RACE). … The DEG2 sequence was not similar to any known protein sequence. …
- NAID 10026705987
- The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons
- Horita Haruhito,Wada Kazuhiro,Rivas Miriam V.,Hara Erina,Jarvis Erich D.
- The Journal of Comparative Neurology 518(14), 2873-2901, 2010-07-15
- … Many immediate early genes (IEG) have activity-dependent induction in a subset of brain subdivisions or neuron types. … Dusp1 is an inactivator of mitogen-activated protein kinase (MAPK), and MAPK in turn activates expression of egr1, one of the most commonly studied IEGs, as determined in cultured cells. …
- NAID 120002317143
- クマザサ含有成分によるヒトサイトメガロウイルスの増殖抑制効果
- 阿久澤 和彦,山田 理恵,畢 長暁,定成 秀貴,松原 京子,土田 裕三,渡邊 邦友,二ノ宮 真之,纐纈 守,村山 次哉
- 日本補完代替医療学会誌 7(1), 25-33, 2010
- … ルス感染後の処理だけでなく,感染前処理した場合にも見られることがわかった.さらにリアルタイム RT-PCR 法および,ウエスタンブロット法による解析の結果,tricin がウイルスの複製・増殖に重要な major immediate early (IE) 遺伝子の発現を抑制することがわかり,tricin が現在使用されている GCV とは異なる作用機序により抗 HCMV 効果をもつことが示され,新たな治療薬としての可能性が示唆された. …
- NAID 130000252240
Related Links
- Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli. They represent a standing response mechanism that is activated at the transcription level in the first ...
- Immediate early protein information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Immediate early protein Description of Immediate early protein Immediate early ...
Related Pictures
★リンクテーブル★
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- 英
- immediate-early protein
- 関
- 最初期タンパク質
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- 英
- immediate-early protein?
- 関
- 初期タンパク質
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- 英
- immediate-early protein
- 関
- 前初期タンパク質
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- 早速の、即座の、即時の。現在に近い。現在の。
- 直接の(direct)、じかの。すぐとなりの、隣接した、(関係などが)一番近い、直近の。直接関係する。
- 関
- direct、directly、fast-acting、immediate-type、immediately、instant、realtime、straightforward
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- 関
- archaic、beginning、early stage、early-stage、initial、initially、preterm、soon
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