hypoxia-inducible factor 1alpha subunit

低酸素誘導因子1α、低酸素応答因子1α

関

HIF-1alpha、HIF1alpha

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. oxygen deficiency causing a very strong drive to correct the deficiency

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
• 2. 赤血球産生調節 regulation of erythropoiesis
• 3. フォンヒッペル・リンダウ病の分子生物学および病因 molecular biology and pathogenesis of von hippel lindau disease
• 4. 先天性赤血球増多症および真性多血症の分子学的病因 molecular pathogenesis of congenital polycythemic disorders and polycythemia vera
• 5. 関節リウマチの病因 pathogenesis of rheumatoid arthritis

English Journal

• TNFα induces expression of HIF-1α mRNA and protein but inhibits hypoxic stimulation of HIF-1 transcriptional activity in airway smooth muscle cells.

• Tsapournioti S, Mylonis I, Hatziefthimiou A, Ioannou MG, Stamatiou R, Koukoulis GK, Simos G, Molyvdas PA, Paraskeva E.SourceDepartment of Physiology, School of Medicine, University of Thessaly, Larissa, Greece.
• Journal of cellular physiology.J Cell Physiol.2013 Aug;228(8):1745-53. doi: 10.1002/jcp.24331.
• Airway smooth muscle cells (ASMCs) participate in tissue remodeling characteristic of airway inflammatory diseases like asthma. Inflammation and hypoxia pathways are often interconnected and the regulatory subunit of the hypoxia inducible factor, HIF-1α, has been recently shown to be induced by cyt
• PMID 23359428

• Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia.

• Clérigues V, Murphy CL, Guillén MI, Alcaraz MJ.SourceDepartment of Pharmacology, University of Valencia, Spain.
• Clinical science (London, England : 1979).Clin Sci (Lond).2013 Jul 1;125(2):99-108. doi: 10.1042/CS20120491.
• HO-1 (haem oxygenase-1) catalyses the degradation of haem and possesses anti-inflammatory and cytoprotective properties. The role of inflammatory mediators in the pathogenesis of OA (osteoarthritis) is becoming increasingly appreciated. In the present study, we investigated the effects of HO-1 induc
• PMID 23406266

• Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processing.

• Wottawa M, Leisering P, Ahlen Mv, Schnelle M, Vogel S, Malz C, Bordoli MR, Camenisch G, Hesse A, Napp J, Alves F, Kristiansen G, Farhat K, Katschinski DM.SourceDepartment of Cardiovascular Physiology, University Medical Center, Georg-August University of Göttingen, D-37073 Göttingen, Germany.
• International journal of cancer. Journal international du cancer.Int J Cancer.2013 Jun 15;132(12):2787-98. doi: 10.1002/ijc.27982. Epub 2012 Dec 27.
• The prolyl-4-hydroxylase domain 1-3 (PHD1-3) enzymes are regulating the protein stability of the α-subunit of the hypoxia-inducible factor-1 (HIF-1), which mediates oxygen-dependent gene expression. PHD2 is the main isoform regulating HIF-1α hydroxylation and thus stability in normoxia. In human c
• PMID 23225569

Japanese Journal

• Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

• WOOD SM.
• J Biol Chem 273, 8360-8368, 1998
• NAID 80010255702

Related Links

• Hif1a hypoxia inducible factor 1, alpha subunit [ (house mouse)]

Gene ID: 15251, updated on 28-Jun-2015 Summary Other designations ARNT-interacting protein, HIF-1-alpha, HIF1-alpha, hypoxia-inducible factor 1-alpha GeneRIFs: Gene References Into Functions NF-kappaB signaling ...

• HIF-1alpha: Hypoxia inducible factor 1, alpha subunit

GoPubMed lists recent and important papers and reviews for hypoxia inducible factor 1, alpha subunit(HIF-1alpha) ... However there are many other effects, partially dependent and independent of those mentioned, that may be useful ...

---

★リンクテーブル★

リンク元	「低酸素誘導因子1α」「HIF1alpha」「HIF-1alpha」「低酸素応答因子1α」
関連記事	「fact」「factor」「inducible」「hypoxia」

「低酸素誘導因子1α」

　　[★]

英

hypoxia-inducible factor 1alpha subunit、HIF-1alpha、HIF1alpha

関

低酸素応答因子1α

「HIF1alpha」

　　[★]

• 低酸素誘導因子1α

関

HIF-1alpha、hypoxia-inducible factor 1alpha subunit

「HIF-1alpha」

　　[★]

• 低酸素誘導因子1α

関

HIF1alpha、hypoxia-inducible factor 1alpha subunit

「低酸素応答因子1α」

　　[★]

英

hypoxia-inducible factor 1alpha subunit

関

低酸素誘導因子1α

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「inducible」

　　[★]

• adj.

• 誘導性の、誘発性の、誘導型の、誘導可能な

関

inducibly、inductive、provocative

「hypoxia」

　　[★]

• n.

• 低酸素, 低酸素症

関

hypoxia-inducible factor