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1. 続発性無月経の病因、診断、および治療 etiology diagnosis and treatment of secondary amenorrhea
2. 運動と関連する無月経および不妊症 amenorrhea and infertility associated with exercise
3. 原発性無月経の病因、診断、および治療 etiology diagnosis and treatment of primary amenorrhea
4. 排卵誘発の概要 overview of ovulation induction
5. 成人における神経性食思不振症：診断、随伴する臨床的特徴、および評価 anorexia nervosa in adults diagnosis associated clinical features and assessment

Functional hypothalamic amenorrhoea: leptin treatment, dietary intervention and counselling as alternatives to traditional practice - systematic review.

Kyriakidis M1, Caetano L2, Anastasiadou N2, Karasu T2, Lashen H2.
European journal of obstetrics, gynecology, and reproductive biology.Eur J Obstet Gynecol Reprod Biol.2016 Mar;198:131-7. doi: 10.1016/j.ejogrb.2016.01.018. Epub 2016 Jan 18.
Functional hypothalamic amenorrhoea (FHA) is a neuroendocrine disorder caused by an energy deficit and characterized by low leptin levels. Based on this, previous studies have suggested that leptin administration may play a crucial role in FHA treatment. However, FHA is also associated with abnormal
PMID 26849039

Short-term estriol administration modulates hypothalamo-pituitary function in patients with functional hypothalamic amenorrhea (FHA).

Genazzani AD1, Podfigurna-Stopa A2, Czyzyk A2, Katulski K2, Prati A1, Despini G1, Angioni S3, Simoncini T4, Meczekalski B2.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.Gynecol Endocrinol.2016 Mar;32(3):253-7. doi: 10.3109/09513590.2015.1118452. Epub 2015 Dec 3.
OBJECTIVE: To evaluate the influence of short-term estriol administration (10 d) on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA).STUDY DESIGN: Controlled clinical study on patients with FHA (n = 12) in a clinical
PMID 26634769

Increased anti-Mullerian hormone levels and ovarian size in a subgroup of women with functional hypothalamic amenorrhea: further identification of the link between polycystic ovary syndrome and functional hypothalamic amenorrhea.

Carmina E1, Fruzzetti F2, Lobo RA3.
American journal of obstetrics and gynecology.Am J Obstet Gynecol.2016 Jan 6. pii: S0002-9378(15)02659-9. doi: 10.1016/j.ajog.2015.12.055. [Epub ahead of print]
BACKGROUND: Functional hypothalamic amenorrhea is a disorder characterized by cessation of menstrual cycles in the absence of organic disease. In most patients, it occurs in adult life after a stressful event and may be related to a condition of mild chronic energy deprivation. The endocrine pattern
PMID 26767792

堂地勉
心身医学 53(7), 640-645, 2013-07-01
性機能(卵巣機能)の維持には適切な体重の維持が必要である.やせても太っても月経異常に陥るが,元の体重に戻せば月経は回復することが多い.肥満による性機能障害(無月経などの月経異常)の機序には,(1)ストレスや食行動の異常が,一方では肥満を惹起し一方では性中枢を障害するという中枢説,(2)末梢説,(3)内臓肥満による内分泌障害説,がある.これらは単独で月経異常を惹起するのではなく,相互に関連して月経異 …
NAID 110009615296

Effect of long-term voluntary exercise and energy restriction on bone mineral density in mature female rats

Yanaka kaoru,Higuchi Mitsuru,Ishimi Yoshiko
The Journal of Physical Fitness and Sports Medicine 1(4), 695-702, 2012
… The female athlete triad is a syndrome that leads to disordered eating, amenorrhea, and osteoporosis. … The pathophysiologic mechanisms that lead to reduced bone mass in female athletes are low energy and functional hypothalamic amenorrhea. … Furthermore, the distinct endocrine profiles observed in this model suggest that energy restriction with voluntary exercise disturbs the hypothalamic-pituitary-ovarian axis. …
NAID 130003379927