WordNet

in or to a high position, amount, or degree; "prices have gone up far too high"
a state of altered consciousness induced by alcohol or narcotics; "they took drugs to get a high on"
a state of sustained elation; "Im on a permanent high these days"
an air mass of higher than normal pressure; "the east coast benefits from a Bermuda high"
a lofty level or position or degree; "summer temperatures reached an all-time high"
a high place; "they stood on high and observed the countryside"; "he doesnt like heights" (同)heights
at a great altitude; "he climbed high on the ladder" (同)high up
used of sounds and voices; high in pitch or frequency (同)high-pitched
happy and excited and energetic (同)in high spirits
slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana) (同)mellow
in a rich manner; "he lives high" (同)richly, luxuriously
(literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'
far up toward the source; "he lives high up the river"
greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself"
surgical removal of one or both testicles (同)orchiectomy

PrepTutorEJDIC

『高い』,高い所にある / 《数の後に置いて》高さが…ある / (数量・程度などが標準より)『高い』,大きい,激しい / (身分・地位が)『高い』,高貴な / 『気高い』,高潔な / (声の調子が)『高い』,鋭い / 値段の高い,金の掛かる,ぜいたくな / 楽しい,陽気な,上得意の / (時・季節が)盛りの,たけなわの / (色が)濃い,赤い / 《話》(酒・麻薬などに)酔って / 『高く』,高い所に / (価値・程度などが)高く,高度に,激しく / 〈C〉《話》高水準,高値 / 〈U〉(自動車の)高速ギア / 〈C〉《話》(麻薬などによる)酔った状態
《話》(あいさつとして)『やあ』,こんにちは / 《英》(注意を促す発声として)おい,ちょっと(hey)

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1. Approach to surgery following primary treatment for advanced testicular germ cell tumors
2. 中等度～高リスク限局性前立腺癌の初期マネージメント initial management of regionally localized intermediate and high risk prostate cancer
3. 小児および思春期の横紋筋肉腫および未分化型肉腫：治療 rhabdomyosarcoma and undifferentiated sarcoma in childhood and adolescence treatment
4. ステージIIのセミノーマの治療 treatment of stage ii seminoma
5. 精巣胚細胞腫瘍の男性に対する治療後フォローアップ posttreatment follow up for men with testicular germ cell tumors

English Journal

The impact of genital trauma on wounded servicemen: Qualitative study.

Lucas PA1, Page PR2, Phillip RD2, Bennett AN3.Author information 1Defence Medical Rehabilitation Centre, Headley Court, Surrey KT18 6JW, UK. Electronic address: lucasp@doctors.org.uk.2Defence Medical Rehabilitation Centre, Headley Court, Surrey KT18 6JW, UK.3Defence Medical Rehabilitation Centre, Headley Court, Surrey KT18 6JW, UK; Leeds Institute of Molecular Medicine, University of Leeds, UK.AbstractBACKGROUND: Recent military operations in Afghanistan have resulted in considerable lower limb trauma. Associated with this trauma have been serious injuries to the genitalia. No previous study has looked at the effect of traumatic genital injury on the individual. This study expresses the impact of these injuries.
Injury.Injury.2014 May;45(5):825-829. doi: 10.1016/j.injury.2013.12.009. Epub 2014 Feb 3.
BACKGROUND: Recent military operations in Afghanistan have resulted in considerable lower limb trauma. Associated with this trauma have been serious injuries to the genitalia. No previous study has looked at the effect of traumatic genital injury on the individual. This study expresses the impact of
PMID 24560873

In vivo deletion of CAR resulted in high bone mass phenotypes in male mice.

Cho HY1, Jung JY, Park H, Yang JY, Jung S, An JH, Cho SW, Kim SW, Kim SY, Kim JE, Park YJ, Shin CS.Author information 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.AbstractConstitutive androstane receptor (CAR) was originally identified as xenobiotic sensor that regulates the expression of cytochrome P450 genes. However, recent studies suggest that this nuclear receptor is also involved in the regulation of energy metabolism including glucose and lipid homeostasis. This study investigated the role of CAR in the regulation of bone mass in vivo using CAR(-/-) mice. Endogenous mRNA expression of CAR was observed in both primary osteoblasts and osteoclast precursors. CAR(-/-) mice have exhibited significant increase in whole body bone mineral density (BMD) by 9.5% (P < 0.01) and 5.5% (P < 0.05) at 10 and 15 weeks of age, respectively, compared with WT mice in males. Microcomputed tomography analysis of proximal tibia demonstrated a significant increase in trabecular bone volume (62.7%), trabecular number (54.1%) in male CAR(-/-) mice compared with WT mice. However, primary culture of calvarial cells exhibited no significant changes in osteogenic differentiation potential between CAR(-/-) and WT. In addition, the number of tartrate-resistant acid-phosphatase positive osteoclasts in the femur and serum level of CTx was not different between CAR(-/-) and WT mice. The higher BMD and microstructural parameters were not observed in female mice. Interestingly, serum level of testosterone in male CAR(-/-) mice was 2.5-fold higher compared with WT mice and the mRNA expressions of Cyp2b9 and 2b10 in the liver, which regulate testosterone metabolism, were significantly down-regulated in male CAR(-/-) mice. Furthermore, the difference in BMD between CAR(-/-) and WT mice disappeared at 8 weeks after performing orchiectomy. CAR(-/-) mice also exhibited significant increase in serum 1,25(OH)2 D3 levels but Cyp 27B1 which converts 25(OH)D3 to 1,25(OH)2 D3 was significantly down-regulated compared to WT mice. These results suggest that in vivo deletion of CAR resulted in higher bone mass, which appears to be a result from reduced metabolism of testosterone due to down-regulation of Cyp2b.
Journal of cellular physiology.J Cell Physiol.2014 May;229(5):561-71. doi: 10.1002/jcp.24478.
Constitutive androstane receptor (CAR) was originally identified as xenobiotic sensor that regulates the expression of cytochrome P450 genes. However, recent studies suggest that this nuclear receptor is also involved in the regulation of energy metabolism including glucose and lipid homeostasis. Th
PMID 24114688

Adult Granulosa Cell Tumors of the Testis: A Report of 32 Cases.

Cornejo KM1, Young RH.Author information 1*James Homer Wright Pathology Laboratories, Massachusetts General Hospital †Department of Pathology, Harvard Medical School, Boston, MA.AbstractThe clinicopathologic features of 32 adult granulosa cell tumors (AGCT) of the testis are presented. The patients were from 14 to 87 years of age (mean 40.0 y) and underwent orchiectomy (n=30) or wedge excision (n=2). None had endocrine-related symptoms. The tumors measured 0.5 to 6.0 cm (mean 2.8 cm) and were predominantly well circumscribed and yellow-tan, except for 1, which had infiltrative borders. The predominant pattern was diffuse, but insular, spindled, microfollicular (Call-Exner bodies), trabecular, corded, watered-silk, palisading, and pseudopapillary patterns were also present. The cells contained round to ovoid nuclei with frequent longitudinal nuclear grooves, indistinct cell borders, and varying amounts of eosinophilic cytoplasm. Most tumors contained limited amounts of fibrocollagenous stroma. The mitotic count ranged from 0 to 18/10 high-power fields (HPF) (mean 4.9/10 HPF, ×400). Two tumors had prominent necrosis, and 1 had vessel invasion. Follow-up information was available for 19 patients, with a mean of 51.0 months (range, 1 to 169 mo). All were without evidence of disease except 1 who had lung metastasis at 24 months. Our findings indicate that the morphologic spectrum of testicular AGCT is similar to that of ovarian AGCT. The majority of testicular examples have a good prognosis (compared with a malignant behavior in 2 of 7 cases in 1 prior series). Lymphovascular invasion, infiltrative borders, and size >4 cm may help in identifying cases with aggressive behavior, as these features were present in the one case with metastasis in our series. Mitotic counts varied and do not appear to be of prognostic significance on the basis of our experience.
The American journal of surgical pathology.Am J Surg Pathol.2014 Apr 3. [Epub ahead of print]
The clinicopathologic features of 32 adult granulosa cell tumors (AGCT) of the testis are presented. The patients were from 14 to 87 years of age (mean 40.0 y) and underwent orchiectomy (n=30) or wedge excision (n=2). None had endocrine-related symptoms. The tumors measured 0.5 to 6.0 cm (mean 2.8 c
PMID 24705318

Japanese Journal

鼠径部腫瘤を契機に発見された精索線維肉腫の1例

伊丹祥隆,細川幸成,飯田孝太 [他],篠原雅岳,林美樹,武長真保,藤本清秀
泌尿器科紀要 = Acta urologica Japonica 59(10), 687-691, 2013-10
… High orchidectomy was performed for the purpose of diagnosis. … Six days after high orchidectomy, retroperitoneal tumor extirpation was performed. …
NAID 120005347149

両側同時精母細胞性セミノーマの1例

丸田大,志田洋平,竹原浩介 [他],大仁田亨,井川掌,酒井英樹
泌尿器科紀要 57(9), 525-528, 2011-09
… This patient was diagnosed with bilateral testicular tumor after various image examinations (ultrasonography/computerized tomography/magnetic resonance imaging) and bilateral high orchidectomy was performed. …
NAID 40018993728

敗血症性肺塞栓症を併発したフルニエ壊疽の1例

増栄成泰,兼松稔,阿部博彦
泌尿器科紀要 56(6), 331-334, 2010-06
… A 47-year-old man with diabetes visited our hospital complaining of high fever, nausea, and scrotal swelling with pain on 11 April, 2009. … The patient underwent right orchidectomy and debridement of the scrotal contents. …
NAID 120002233412