WordNet
- the process of declining from a higher to a lower level of effective power or vitality or essential quality (同)devolution
- passing from a more complex to a simpler biological form (同)retrogression
PrepTutorEJDIC
- 退歩,退化,墜落
- (砂糖などが)粒の,粒状の / (紙・革などが)表面がざらざらしている
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- 1. 腎疾患の診断における尿検査 urinalysis in the diagnosis of kidney disease
- 2. 腫瘍随伴性小脳変性症 paraneoplastic cerebellar degeneration
- 3. 大顆粒T細胞リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell large granular lymphocyte leukemia
- 4. ナチュラルキラー（NK）細胞大顆粒リンパ球性白血病 natural killer nk cell large granular lymphocyte leukemia
- 5. 大顆粒リンパ球性白血病の治療 treatment of large granular lymphocyte leukemia
English Journal
- Changes in CB1 and CB2 receptors in the post-mortem cerebellum of humans affected by spinocerebellar ataxias.
- Rodríguez-Cueto C1, Benito C, Fernández-Ruiz J, Romero J, Hernández-Gálvez M, Gómez-Ruiz M.Author information 1Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigación en Neuroquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.AbstractBACKGROUND AND PURPOSE: Spinocerebellar ataxias (SCAs) are a family of chronic progressive neurodegenerative diseases, clinically and genetically heterogeneous, characterized by loss of balance and motor coordination due to degeneration of the cerebellum and its afferent and efferent connections. Unlike other motor disorders, the possible role of changes in the endocannabinoid system in the pathogenesis of SCAs has not been investigated.
- British journal of pharmacology.Br J Pharmacol.2014 Mar;171(6):1472-89. doi: 10.1111/bph.12283.
- BACKGROUND AND PURPOSE: Spinocerebellar ataxias (SCAs) are a family of chronic progressive neurodegenerative diseases, clinically and genetically heterogeneous, characterized by loss of balance and motor coordination due to degeneration of the cerebellum and its afferent and efferent connections. Un
- PMID 23808969
- Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations.
- Alami NH1, Smith RB1, Carrasco MA2, Williams LA3, Winborn CS4, Han SS5, Kiskinis E3, Winborn B1, Freibaum BD1, Kanagaraj A1, Clare AJ1, Badders NM1, Bilican B6, Chaum E4, Chandran S6, Shaw CE7, Eggan KC3, Maniatis T2, Taylor JP8.Author information 1Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.2Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA.3Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.4Department of Ophthalmology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.5Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.6Euan MacDonald Centre for Motor Neurone Disease Research, Medical Research Council Centre for Regenerative Medicine, Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, UK.7Departments of Clinical Neuroscience and Neurodegeneration and Brain Injury, King's College London and King's Health Partners, MRC Centre for Neurodegeneration Research, London SE5 8AF, UK.8Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: jpaul.taylor@stjude.org.AbstractThe RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the cytoplasmic inclusions characteristic of amyotrophic lateral sclerosis and some types of frontotemporal lobar degeneration. The importance of TDP-43 in disease is underscored by the fact that dominant missense mutations are sufficient to cause disease, although the role of TDP-43 in pathogenesis is unknown. Here we show that TDP-43 forms cytoplasmic mRNP granules that undergo bidirectional, microtubule-dependent transport in neurons in vitro and in vivo and facilitate delivery of target mRNA to distal neuronal compartments. TDP-43 mutations impair this mRNA transport function in vivo and in vitro, including in stem cell-derived motor neurons from ALS patients bearing any one of three different TDP-43 ALS-causing mutations. Thus, TDP-43 mutations that cause ALS lead to partial loss of a novel cytoplasmic function of TDP-43.
- Neuron.Neuron.2014 Feb 5;81(3):536-43. doi: 10.1016/j.neuron.2013.12.018.
- The RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the cytoplasmic inclusions characteristic of amyotrophic lateral sclerosis and some types of frontotemporal lobar degeneration. The i
- PMID 24507191
Japanese Journal
- Cardiotoxic Changes of Colchicine Intoxication in Rats: Electrocardiographic, Histopathological and Blood Chemical Analysis
- TOCHINAI Ryota,SUZUKI Katsuya,NAGATA Yuriko,ANDO Minoru,HATA Chie,KOMATSU Kayoko,SUZUKI Tomo,UCHIDA Kazumi,KADO Shoichi,KANEKO Kimiyuki,KUWAHARA Masayoshi
- Journal of Toxicologic Pathology, 2014
- … Histopathologically, colchicine-treated rats showed eosinophilic granular degeneration and cytoplasmic vacuolation of ventricular myocardial cells but no remarkable change in the atrioventricular node. …
- NAID 130004433135
- Unpredictable Chronic Stress-Induced Reproductive Suppression Associated with the Decrease of Kisspeptin Immunoreactivity in Male Mice
- HIRANO Tetsushi,KOBAYASHI Yoshihiro,OMOTEHARA Takuya,TATSUMI Atsutoshi,HASHIMOTO Rie,UMEMURA Yuria,NAGAHARA Daichi,MANTANI Youhei,YOKOYAMA Toshifumi,KITAGAWA Hiroshi,HOSHI Nobuhiko
- Journal of Veterinary Medical Science, 2014
- … Although the ARC was not morphologically altered in either the stressed or non-stressed group, granular kisspeptin immunoreactivities decreased slightly in the stress group. … In the testes of the stress group, several signs of testicular degeneration were observed, including increased numbers of ssDNA-positive cells per seminiferous tubule, thinning, vacuoled seminiferous epithelia and multinucleated giant cells. …
- NAID 130004432200
Related Links
- cloud·y swell·ing swelling of cells due to injury to the membranes affecting ionic transfer; causes an accumulation of intracellular water. Synonym(s): albuminous swelling, granular degeneration, hydropic degeneration, parenchymatous degeneration
- granular degeneration Granular Fertilizers granular fracture granular gland granular ice granular leukocyte granular material granular powder granular snow granular soil granular structure Granular Venereal Disease of Cattle ? ...
Related Pictures
★リンクテーブル★
| リンク元 | 「表皮融解性角質増殖」 |
| 関連記事 | 「degeneration」「granular」 |
「表皮融解性角質増殖」
「degeneration」
- n.
- 関
- degeneracy、degenerate、degenerative、denaturation、denature、involution、retract、retrograde degeneration、retrograde degradation、unfolding
「granular」
- adj.
- 顆粒状の、顆粒の、粒状の