痛風発作

WordNet

the act of attacking; "attacks on women increased last year"; "they made an attempt on his life" (同)attempt
(military) an offensive against an enemy (using weapons); "the attack began at dawn" (同)onslaught, onset, onrush
a decisive manner of beginning a musical tone or phrase (同)tone-beginning
an offensive move in a sport or game; "they won the game with a 10-hit attack in the 9th inning"
strong criticism; "he published an unexpected attack on my work"
a sudden occurrence of an uncontrollable condition; "an attack of diarrhea"
begin to injure; "The cancer cells are attacking his liver"; "Rust is attacking the metal"
set to work upon; turn ones energies vigorously to a task; "I attacked the problem as soon as I got out of bed"
the onset of a corrosive or destructive process (as by a chemical agent); "the film was sensitive to attack by acids"; "open to attack by the elements"
attack in speech or writing; "The editors of the left-leaning paper attacked the new House Speaker" (同)round, assail, lash out, snipe, assault
take the initiative and go on the offensive; "The Serbs attacked the village at night"; "The visiting team started to attack" (同)aggress
launch an attack or assault on; begin hostilities or start warfare with; "Hitler attacked Poland on September 1, 1939 and started World War II"; "Serbian forces assailed Bosnian towns all week" (同)assail
a painful inflammation of the big toe and foot caused by defects in uric acid metabolism resulting in deposits of the acid and its salts in the blood and joints (同)gouty_arthritis, urarthritis
suffering from gout

PrepTutorEJDIC

…'を'『襲う』,『攻撃する』;(ゲームで)…'を'攻める / (演説・文書などで)…'を'『非難する』,攻撃する / 〈病気・不運などが〉…'を'襲う,冒す / 〈仕事など〉‘に'勢いよく取りかかる,着手する / 『攻撃をする』 / 〈U〉〈C〉(…に対する)『攻撃』;(ゲームの)攻め;非難《+『on』(『upon, against』)+『名』》 / 〈C〉発病,発作 / 〈U〉(仕事への)着手,開始
〈U〉痛風 / 〈C〉(特に血の)滴り,塊
痛風の,痛風にかかった

UpToDate Contents

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1. 急性痛風の治療 treatment of acute gout
2. 痛風の臨床症状および診断 clinical manifestations and diagnosis of gout
3. 痛風再発の予防 prevention of recurrent gout
4. 痛風性関節炎の病態生理 pathophysiology of gouty arthritis
5. 片麻痺性片頭痛 hemiplegic migraine

English Journal

Molecular basis of oxidative stress in gouty arthropathy.

Zamudio-Cuevas Y1,2, Hernández-Díaz C1, Pineda C1, Reginato AM3, Cerna-Cortés JF2, Ventura-Ríos L1, López-Reyes A4.
Clinical rheumatology.Clin Rheumatol.2015 Oct;34(10):1667-72. doi: 10.1007/s10067-015-2933-y. Epub 2015 Apr 9.
Gout is a disorder of urate metabolism in which persistent high urate levels in the extracellular fluids result in the deposition of monosodium urate (MSU) crystal in joints and periarticular tissues. In recent years, this disease represents an increasingly common health problem, so the pace of inve
PMID 25854697

Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation.

Jhang JJ1, Lu CC1, Ho CY1, Cheng YT1, Yen GC1,2.
Journal of agricultural and food chemistry.J Agric Food Chem.2015 Aug 26;63(33):7343-52. doi: 10.1021/acs.jafc.5b02605. Epub 2015 Aug 12.
Gouty inflammation results from the stimulation of monosodium urate (MSU). Interleukin-1β (IL-1β) secretion is the primary clinical manifestation of MSU attack, and MSU activates IL-1β through a nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome
PMID 26234731

Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome.

Cumpelik A1, Ankli B2, Zecher D3, Schifferli JA1.
Annals of the rheumatic diseases.Ann Rheum Dis.2015 Aug 5. pii: annrheumdis-2015-207338. doi: 10.1136/annrheumdis-2015-207338. [Epub ahead of print]
OBJECTIVES: Gout is a highly inflammatory but self-limiting joint disease induced by the precipitation of monosodium urate (MSU) crystals. While it is well established that inflammasome activation by MSU mediates acute inflammation, little is known about the mechanism controlling its spontaneous res
PMID 26245757

Japanese Journal

小児期および思春期に発症した痛風に関する全国調査

加藤玲奈,久保田優,東山幸恵,永井亜矢子
痛風と核酸代謝 38(1), 43-48, 2014
痛風に関する調査は成人を対象としたものが大部分であり，小児科領域での痛風の頻度を含めた実態はほとんど明らかになっていない．そこで今回，小児期および思春期における痛風の頻度とその実態に関する全国規模の調査を行った（調査期間：平成25年5-7月）．小児科を有する全国の935病院を対象に，過去5年間（平成20-24年度）における小児科入院・外来患者数，痛風症例数を一次アンケートにて調査した．痛風症例が報 …
NAID 130004680219

急性痛風発作への対応 (特集高尿酸血症・痛風の診療)

谷口敦夫
日本医師会雑誌 140(2), 285-288, 2011-05
NAID 40018782173

血液透析により誘発される痛風発作を繰り返した巨大痛風結節患者の1例

青山東五,渡会梨紗子,根本千香子 [他],田中圭,村野順也,坂間玲子,田崎尋美,小林圭,岡本智子,内藤正吉,清水健史,佐野隆,長場泰,竹内康雄,坂本尚登,鎌田貢壽
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 43(2), 195-200, 2010-02-28
症例は68歳，男性．26歳時，両膝関節と両足関節の疼痛，高尿酸血症により痛風と診断された．その後，5年に1～2回程度の痛風発作を繰り返していた．腎機能は徐々に低下し，尿毒症に進展，血清Crは6.9 mg/dL，血清UAは10.5 mg/dLと上昇した．2006年5月に入院し，血液透析を開始した．血液透析導入時，痛風結節を全身に認めた．血液透析4回目以降，両膝関節近傍と右肘関節遠位部の痛風結節に自発 …
NAID 10026316444