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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/13 11:07:32」(JST)

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Long-term exposure to diesel engine exhaust induces primary DNA damage: a population-based study.

Duan H1, Jia X1, Zhai Q2, Ma L3, Wang S3, Huang C1, Wang H4, Niu Y1, Li X1, Dai Y1, Yu S5, Gao W6, Chen W3, Zheng Y1.
Occupational and environmental medicine.Occup Environ Med.2016 Feb;73(2):83-90. doi: 10.1136/oemed-2015-102919. Epub 2015 Oct 21.
OBJECTIVES: Diesel engine exhaust (DEE) is a ubiquitous environmental pollutant and is carcinogenic to humans. To seek early and sensitive biomarkers for prediction of adverse health effects, we analysed the components of DEE particles, and examined the genetic and oxidative damages in DEE-exposed w
PMID 26491144

A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine-DNA glycosylase.

Li H1, Endutkin AV2, Bergonzo C1, Campbell AJ1, de Los Santos C3, Grollman A3, Zharkov DO4, Simmerling C5.
Nucleic acids research.Nucleic Acids Res.2016 Jan 29;44(2):683-94. doi: 10.1093/nar/gkv1092. Epub 2015 Nov 8.
In contrast to proteins recognizing small-molecule ligands, DNA-dependent enzymes cannot rely solely on interactions in the substrate-binding centre to achieve their exquisite specificity. It is widely believed that substrate recognition by such enzymes involves a series of conformational changes in
PMID 26553802

The Corynebacterium pseudotuberculosis genome contains two formamidopyrimidine-DNA glycosylase enzymes, only one of which recognizes and excises 8-oxoguanine lesion.

Arantes LS1, Nova LG2, Resende BC3, Bitar M4, Coelho IE5, Miyoshi A6, Azevedo VA7, Lara Dos Santos L8, Machado CR9, de Oliveira Lopes D10.
Gene.Gene.2016 Jan 10;575(2 Pt 1):233-43. doi: 10.1016/j.gene.2015.08.065. Epub 2015 Sep 2.
The GO-system is a DNA repair mechanism that prevents and corrects oxidative DNA damage. Formamidopyrimidine-DNA glycosylase (FPG/MutM) participates in this system, avoiding the mutagenic effects of 8-oxoguanine lesion into DNA. Corynebacterium pseudotuberculosis, the etiological agent of caseous ly
PMID 26341054

Nishio Yoshimi,Nakano Yumiko,Deguchi Yuya [他],Terato Hiroaki,Ide Hiroshi,Ito Chiaki,Ishida Hitoshi,Takagi Kuniaki,Tsuboi Hirohito,Kinae Naohide,Shimoi Kayoko
環境変異原研究 = Genes and environment : the official journal of the Japanese Environmental Mutagen Society 29(1), 17-22, 2007-02-20
… Single cell gel electrophoresis (comet assay) using formamidopyrimidine DNA glycosylase (FPG) was done to determine oxidative DMA damage in mouse peripheral blood cells. … Although no significant differences in plasma concentration of ascorbic acid and a-tocopherol were observed between the control mice and the isolated mice, oxidative DNA damage was induced in the isolated mice for 7 days and 30 days. …
NAID 110006240239

Analysis of 8-Hydroxyguanine (8-OH-Gua) Released from DNA by the Formamidopyrimidine DNA Glycosylase (Fpg) Protein : A Reliable Method to Estimate Cellular Oxidative Stress

Orimo Hiroshi,Mei Nan,Boiteux Serge [他],TOKURA Yoshiki,KASAI Hiroshi
Journal of radiation research 45(3), 455-460, 2004-10-10
… To improve the analyses of a form of oxidative DNA damage, 8-hydroxyguanine (8-OH-Gua), we treated isolated DNA with formamidopyrimidine DNA glycosylase (Fpg) and analyzed the released 8-OH-Gua by using a high-performance liquid chromatography system equipped with an electrochemical detector (HPLC-ECD). … After the isolated DNA was treated with the Fpg protein, we analyzed the released 8-OH-Gua by using an HPLC-ECD. …
NAID 110004041048

Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylase

DNA-formamidopyrimidine glycosylase
Identifiers
EC number	3.2.2.23
CAS number	78783-53-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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PMC	articles
PubMed	articles
NCBI	proteins