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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/02 05:51:25」(JST)

Fluticasone is a synthetic glucocorticoid.^[1]

Both the furoate and propionate forms are used as topical anti-inflammatories:^[2]

References

^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2012), Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins, p. 600, ISBN 1451153597.
^ Spratto, George R.; Woods, Adrienne L. (2012), Delmar Nurse's Drug Handbook 2012, Cengage Learning, p. 748, ISBN 1111310653.

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2. 好酸球性食道炎の治療 treatment of eosinophilic esophagitis
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4. 吸入ステロイドの主な副作用 major side effects of inhaled glucocorticoids
5. 安定した慢性閉塞性肺疾患（COPD）のマネージメント management of stable chronic obstructive pulmonary disease

Glucocorticoid-Augmented Efferocytosis Inhibits Pulmonary Pneumococcal Clearance in Mice by Reducing Alveolar Macrophage Bactericidal Function.

Stolberg VR1, McCubbrey AL2, Freeman CM3, Brown JP4, Crudgington SW4, Taitano SH2, Saxton BL5, Mancuso P6, Curtis JL7.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Jul 1;195(1):174-84. doi: 10.4049/jimmunol.1402217. Epub 2015 May 18.
Inhaled corticosteroids (ICS) increase community-acquired pneumonia (CAP) incidence in patients with chronic obstructive pulmonary disease (COPD) by unknown mechanisms. Apoptosis is increased in the lungs of COPD patients. Uptake of apoptotic cells (ACs) ("efferocytosis") by alveolar macrophages (AM
PMID 25987742

Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients.

Chang HS1, Heo JS, Shin SW, Bae DJ, Song HJ, Jun JA, Kim JD, Park JS, Park BL, Shin HD, Park CS.
Pharmacogenetics and genomics.Pharmacogenet Genomics.2015 Jul;25(7):334-42. doi: 10.1097/FPC.0000000000000141.
BACKGROUND: Genetic polymorphisms may be responsible for the wide variation in response to inhaled corticosteroids in asthmatic patients. We had previously reported that one polymorphism rs7772821, located on the 3'-UTR of trace amine-associated receptor 6 (TAAR6), is significantly associated with p
PMID 25919112

Improvements in lung function with umeclidinium/vilanterol versus fluticasone propionate/salmeterol in patients with moderate-to-severe COPD and infrequent exacerbations.

Donohue JF1, Worsley S2, Zhu CQ3, Hardaker L4, Church A5.
Respiratory medicine.Respir Med.2015 Jul;109(7):870-81. doi: 10.1016/j.rmed.2015.04.018. Epub 2015 May 8.
BACKGROUND: Umeclidinium (UMEC; long-acting muscarinic antagonist [LAMA])/vilanterol (VI; long-acting beta2-agonist [LABA]) and fluticasone propionate/salmeterol (FP/SAL) (inhaled corticosteroid/LABA) are approved maintenance therapies for chronic obstructive pulmonary disease (COPD). Two studies co
PMID 26006754

Collagen Gel Contraction Assay Using Human Bronchial Smooth Muscle Cells and Its Application for Evaluation of Inhibitory Effect of Formoterol

井上考司,橘さやか,中西徳彦,森高智典
気管支学 : 日本気管支研究会雑誌 36(2), 143-146, 2014-03-25
背景.気管肉芽狭窄に対して様々な内視鏡的加療が報告されているが,未だコンセンサスの得られた治療法はなく,治療方針の決定には合併症やコストにも留意が必要である.吸入ステロイドは気管支喘息など非感染性慢性気道炎症疾患に対して安全かつ安価な治療法であるが,我々は気管形成術後の吻合部肉芽狭窄に対してフルチカゾン吸入が有効であった1例を経験した.症例.67歳女性.気管挿管後の瘢痕性狭窄に対して気管形成術を行 …
NAID 110009807527

リンク元	「フルチカゾン」「Flonase」「Flovent」
拡張検索	「fluticasone propionate」

Fluticasone
Systematic (IUPAC) name
	S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-; 6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-; 6,7,8,11,12,14,15,16-octahydrocyclopenta[a]; phenanthrene-17-carbothioate
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	C for Intranasal and Inhaled;
Legal status	UK: POM; US: ℞-only;
Routes	Intranasal, Inhaled, Topical Cream or Ointment
Pharmacokinetic data
Bioavailability	0.51% (Intranasal)
Protein binding	91%
Metabolism	Intranasal; Hepatic (CYP3A4-mediated)
Half-life	10 hours
Excretion	Renal
Identifiers
CAS number	90566-53-3 ; 80474-14-2 (propionate)
ATC code	D07AC17 R01AD08 R03BA05
PubChem	CID 5311101
DrugBank	DB00588
ChemSpider	4470631
UNII	CUT2W21N7U
KEGG	D07981
ChEBI	CHEBI:5134
ChEMBL	CHEMBL1201396
Chemical data
Formula	C22H27F3O4S
Mol. mass	444.508 g/mol
	SMILES O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C;
	InChI InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:MGNNYOODZCAHBA-GQKYHHCASA-N ;
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