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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/15 11:06:12」(JST)

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Fluticasone propionate is a corticosteroid derived from fluticasone used to treat asthma and allergic rhinitis (hay fever). It is also used to treat eosinophilic esophagitis.

GlaxoSmithKline currently markets fluticasone propionate as Flovent (USA and Canada) and Flixotide (EU) for asthma, and as Flonase (USA and Canada), Flixonase (Australia, Brazil, EU, India, Israel, South Africa, and South Korea) and Pirinase (UK) for allergic rhinitis (hay fever), as well as a combination of fluticasone and salmeterol as Advair (USA and Canada) or Seretide^[1] (EU).In India it is also marketed by Intas under the trade name 'Ezicas'. Teva markets fluticasone propionate as Nasofan in Italy. It is available as Fluticone in India. It is also available as a cream (marketed as Cutivate or Flutivate) for the treatment of eczema and psoriasis.

Flonase patent issues [edit]

FloVent HFA inhaler

(FDA) approved the sale of a generic version of Flonase on February 22, 2006. On February 23, 2006, GlaxoSmithKline (GSK) was able to obtain a temporary 10-day restraining order from a federal judge in Baltimore blocking the shipment and sales of the approved generic versions of Flonase. The restraining order lasted until March 6, 2006. The basis of the complaint by GSK was that the FDA failed to follow its own regulations in approving the generics and failed to apply the same quality standards for the generic version as it did for Flonase. GSK made these arguments in petitions filed with the FDA, but the FDA rejected those petitions. The Maryland District Court denied the request by GSK to extend the ban on Flonase generics beyond March 6, 2006, and GSK released a statement that they would not appeal the ruling.^[2] The ruling meant that sales of generic versions of Flonase could proceed.

Side effects [edit]

In studies the topical drug has been associated with burning, stinging, skin irritation, blisters, dryness, skin infection, infected eczema, viral warts, impetigo, atopic dermatitis, pruritus, exacerbation of pruritus, exacerbation of eczema, erythema, and folliculitis.^[3]

There are also numerous side effects associated with the oral version of this medication including headache, stuffy or runny nose, difficulty speaking, sore or irritated throat and painful white patches in the mouth or throat.^[4]

References [edit]

^ Allen & Hanburys. Package Leaflet: Information for the User of Seretide(tm) Evohaler(tm). GSK.
^ Medical News Today
^ FDA
^ Fluticasone Oral Inhalation U.S. National Library of Medicine

UpToDate Contents

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1. 思春期および成人における間欠型喘息および軽症持続型喘息の治療 treatment of intermittent and mild persistent asthma in adolescents and adults
2. 好酸球性食道炎の治療 treatment of eosinophilic esophagitis
3. 12歳未満の小児における慢性喘息：持続性喘息の治療およびコントロール薬 asthma in children younger than 12 years treatment of persistent asthma with controller medications
4. 吸入ステロイドの主な副作用 major side effects of inhaled glucocorticoids
5. 安定した慢性閉塞性肺疾患（COPD）のマネージメント management of stable chronic obstructive pulmonary disease

English Journal

Once-daily fluticasone furoate 50 mcg in mild-to-moderate asthma: a 24-week placebo-controlled randomized trial.

Busse WW1, Bateman ED, O'Byrne PM, Lötvall J, Woodcock A, Medley H, Forth R, Jacques L.
Allergy.Allergy.2014 Nov;69(11):1522-30. doi: 10.1111/all.12480. Epub 2014 Aug 22.
BACKGROUND: Inhaled glucocorticosteroids (ICS) are the mainstay of treatment in asthma. Fluticasone furoate (FF) is a novel, once-daily ICS asthma therapy. This study investigated the efficacy and safety of FF 50 mcg in patients with mild-to-moderate persistent asthma.METHODS: A 24-week, multicent
PMID 25040613

Osteoporosis in the at-risk asthmatic.

Aljubran SA1, Whelan GJ, Glaum MC, Lockey RF.
Allergy.Allergy.2014 Nov;69(11):1429-39. doi: 10.1111/all.12438. Epub 2014 Jul 21.
The effect of inhaled glucocorticosteroids (ICS) on bone metabolism and subsequent osteoporosis is controversial. Explanations for this controversy include various study designs, duration of use, outcome measures, and population demographics of research studies with intranasal or inhalational ICS. P
PMID 25039444

Fluticasone furoate maintains epithelial homeostasis via leptin/leptin receptor pathway in nasal cells.

Bruno A1, Gerbino S, Ferraro M, Siena L, Bonura A, Colombo P, La Grutta S, Gallina S, Ballacchino A, Giammanco M, Gjomarkaj M, Pace E.
Molecular and cellular biochemistry.Mol Cell Biochem.2014 Nov;396(1-2):55-65. doi: 10.1007/s11010-014-2142-z. Epub 2014 Jul 29.
Leptin is involved in the lung epithelial homeostasis. Its role in the nasal tract is largely unknown. Allergic rhinitis (AR) is induced by the allergen exposure leading to consequential structural abnormalities in the nasal epithelium. Topical corticosteroids are recommended as first-line therapy i
PMID 25070832

Japanese Journal

A Preliminary Study of Thermal Comfort in Malaysia's Single Storey Terraced Houses(Environmental Engineering)

Murti Nugroho Agung,Hamdan Ahmad Mohd,Remaz Ossen Dilshan
Journal of Asian architecture and building engineering 6(1), 175-182, 2007-05-15
… Validation of CFD FloVent was carried out through the comparison of field measurements. …
NAID 110006250068

Related Pictures

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リンク元

「フルチカゾン」

Fluticasone propionate
Systematic (IUPAC) name
	S-(fluoromethyl)-6α,9-difluoro-11β, 17-dihydroxy-16α-methyl-3-oxoandrosta-1, 4-diene-17β-carbothioate, 17-propanoate
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	C for Intranasal and Inhaled
Legal status	P (UK) Rx Only (US)
Routes	Intranasal, Inhaled, Topical Cream or Ointment
Pharmacokinetic data
Bioavailability	0.51% (Intranasal)
Protein binding	91%
Metabolism	Intranasal; Hepatic (CYP3A4-mediated)
Half-life	10 hours
Excretion	Renal
Identifiers
CAS number	80474-14-2
ATC code	D07AC17 & D07AC04 (topical)
PubChem	CID 444036
DrugBank	DB00588
ChemSpider	392059
UNII	O2GMZ0LF5W
ChEBI	CHEBI:31441
ChEMBL	CHEMBL1473
Chemical data
Formula	C25H31F3O5S
Mol. mass	500.57 g/mol
	SMILES O=C(SCF)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C;
	InChI InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1 ; Key:WMWTYOKRWGGJOA-CENSZEJFSA-N ;
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英: fluticasone
化: プロピオン酸フルチカゾン fluticasone propionate
商: アドエア、アラミスト、キリガミール、スカイロン、ファビ、フルタイド、フルチカノーズ、フルナーゼ、フロラーズ、ミリカレット、フルナーゼ、Flonase, Flovent
関: 耳鼻科用剤

[1] Allen & Hanburys. Package Leaflet: Information for the User of Seretide(tm) Evohaler(tm). GSK.

[2] Medical News Today

[3] FDA

[4] Fluticasone Oral Inhalation U.S. National Library of Medicine

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案内

Flovent