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Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs.

Shin EJ, Bach JH, Lee SY, Kim JM, Lee J, Hong JS, Nabeshima T, Kim HC.SourceNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
Journal of pharmacological sciences.J Pharmacol Sci.2011;116(2):137-48. Epub 2011 May 21.
Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan
PMID 21606622

Chou YC, Chung YT, Liu TY, Wang SY, Chau GY, Chi CW, Soucek P, Krausz KW, Gelboin HV, Lee CH, Ueng YF.SourcePharmacy Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Journal of pharmaceutical sciences.J Pharm Sci.2010 Feb;99(2):1063-77.
To characterize the human cytochrome P450 (P450) forms involved in dimemorfan oxidation (DFO), human liver microsomes, and recombinant P450s were investigated. Liquid chromatography-mass spectral analysis suggested that metabolite (M)1 ([M + H](+) m/z at 272.200) and M2 ([M + H](+) m/z at 242.190) w
PMID 19593786

Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice.

Wang YH, Shen YC, Liao JF, Lee CH, Chou CY, Liou KT, Chou YC.SourceDepartment of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan.
British journal of pharmacology.Br J Pharmacol.2008 Jul;154(6):1327-38. Epub 2008 May 26.
BACKGROUND AND PURPOSE: Dimemorfan (a sigma1 receptor agonist) showed neuroprotective properties in animal models of inflammation-mediated neurodegenerative conditions, but its effects on inflammatory cells and systemic inflammation remain unclear.EXPERIMENTAL APPROACH: The effects of dimemorfan on
PMID 18500357

Kim JY, Kim HC, Kim J, Lee J.SourceSmall Molecule Group, Central Research Institute, Green Cross Corporation, Yongin, Korea.
Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).2008 Jul;56(7):985-7.
Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially availab
PMID 18591815

久保田幸雄,中島佐起子,園部尚,川田裕溢,仲井由宣
Chemical & pharmaceutical bulletin 28(3), 815-823, 1980-03-25
… The aims of the present investigation were to compare the dissolution properties of dimemorfan phosphate and dimemorfan and to control the dissolution of dimemorfan species, which are pharmacologically equivalent, by using suitable mixtures of dimemorfan phosphate and dimemorfan. … The solubility of dimemorfan was studied in solutions of various pH values. …
NAID 110003623987

久保田幸雄,中島佐起子,園部尚,川田裕溢,仲井由宣
ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 28(3), 815-823, 1980
… The aims of the present investigation were to compare the dissolution properties of dimemorfan phosphate and dimemorfan and to control the dissolution of dimemorfan species, which are pharmacologically equivalent, by using suitable mixtures of dimemorfan phosphate and dimemorfan. … The solubility of dimemorfan was studied in solutions of various pH values. …
NAID 130003940913