ジメモルファン
- 関
- dimemorfan phosphate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/09 22:19:59」(JST)
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Dimemorfan
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| Systematic (IUPAC) name |
| (4bS,8aS,9S)-3,11-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene |
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Identifiers |
|
CAS Registry Number
|
36309-01-0 Y |
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ATC code
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R05DA11 |
| PubChem |
CID: 3037918 |
| ChemSpider |
16735785 Y |
| UNII |
623OAC38YU Y |
| KEGG |
D07848 Y |
| ChEMBL |
CHEMBL2106325 |
| Chemical data |
| Formula |
C18H25N |
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Molecular mass
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255.398 g/mol |
SMILES
- CC1=CC2=C(C[C@@H]3N(CC[C@@]42CCCC[C@H]34)C)C=C1
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InChI
-
InChI=1S/C18H25N/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3/t15-,17+,18+/m1/s1 Y
Key:KBEZZLAAKIIPFK-NJAFHUGGSA-N Y
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| Y (what is this?) (verify) |
Dimemorfan is an antitussive or cough suppressant which acts as a sigma receptor agonist.[1][2] It is an analogue of dextromethorphan and dextrorphan, but lacks significant NMDA receptor antagonistic action and dissociative effects, thereby having reduced abuse potential and adverse effects in comparison.[3]
See also
- Cough syrup
- Dextromethorphan
- Dextrorphan
- Morphinan
References
- ^ Wang, H. H.; Chien, J. W.; Chou, Y. C.; Liao, J. F.; Chen, C. F. (2003). "Anti-amnesic effect of dimemorfan in mice". British Journal of Pharmacology 138 (5): 941–949. doi:10.1038/sj.bjp.0705117. PMC 1573728. PMID 12642396. edit
- ^ Shin, E. J.; Nah, S. Y.; Kim, W. K.; Ko, K. H.; Jhoo, W. K.; Lim, Y. K.; Cha, J. Y.; Chen, C. F.; Kim, H. C. (2005). "The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via σ1 receptor activation: Comparison with the effects of dextromethorphan". British Journal of Pharmacology 144 (7): 908–918. doi:10.1038/sj.bjp.0705998. PMC 1576070. PMID 15723099. edit
- ^ Chou, Y. C.; Liao, J. F.; Chang, W. Y.; Lin, M. F.; Chen, C. F. (1999). "Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan". Brain Research 821 (2): 516–519. doi:10.1016/S0006-8993(99)01125-7. PMID 10064839. edit
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Cough and cold preparations (R05)
|
|
| Expectorants |
- Althea root
- Antimony pentasulfide
- Creosote
- Guaiacolsulfonate
- Guaifenesin
- Ipecacuanha (Syrup of ipecac)
- Levoverbenone
- Potassium iodide
- Senega
- Tyloxapol
- Ammonium Chloride
|
|
| Mucolytics |
- Acetylcysteine
- Ambroxol
- Bromhexine
- Carbocisteine
- Domiodol
- Dornase alfa
- Eprazinone
- Erdosteine
- Letosteine
- Mannitol
- Mesna
- Neltenexine
- Sobrerol
- Stepronin
- Tiopronin
|
|
| Cough suppressants |
Opium alkaloids,
opioids,
and derivatives |
- Acetyldihydrocodeine
- Benzylmorphine
- Butorphanol
- Codeine
- Dextromethorphan
- Dihydrocodeine
- Dimemorfan
- Droxypropine
- Ethylmorphine
- Heroin
- Hydrocodone
- Hydromorphone
- Isoaminile
- Laudanum
- Levomethadone
- Levopropoxyphene
- Methadone
- Nicocodeine
- Nicodicodeine
- Normethadone
- Noscapine
- Pholcodine
- Thebacon
- Tipepidine
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|
| Other |
- Benzonatate
- Benproperine
- Bibenzonium bromide
- Butamirate
- Clobutinol
- Clofedanol
- Cloperastine
- Diphenhydramine
- Dibunate
- Dimethoxanate
- Dropropizine
- Fedrilate
- Glaucine
- Levodropropizine
- Meprotixol
- Morclofone
- Nepinalone
- Oxolamine
- Oxeladin
- Pentoxyverine
- Pipazetate
- Prenoxdiazine
- Piperidione
- Zipeprol
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|
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Index of the respiratory system
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|
| Description |
- Anatomy
- Physiology
- Development
|
|
| Disease |
- Congenital
- Neoplasms and cancer
- Chest trauma
- Infection
- common cold
- pneumonia
- tuberculosis
- Other
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- nasal
- throat
- obstructive airway diseases
- cough and cold
- histaminergics
- pulmonary arterial hypertension
- other
- Surgery
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Sigmaergics
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Receptor
(ligands)
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σ (1, 2)
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- Agonists: 3-MeO-PCE
- 3-MeO-PCP
- 3-PPP
- 4-MeO-PCP
- 4-IBP
- 4-PPBP
- Afobazole
- Alazocine
- Amitriptyline
- Arketamine
- BD-1,008
- Berberine
- Captodiame
- Citalopram
- Clorgiline
- Cocaine
- Cutamesine
- Cyclazocine
- DHEA
- DHEA-S
- Desipramine
- Dextrallorphan
- Dextromethorphan
- Dextrorphan
- Dimemorfan
- DMT
- DTG
- EMD-57,445
- Escitalopram
- Fluoxetine
- Fluvoxamine
- Heroin
- Igmesine
- Imipramine
- JO-1,784
- Ketamine
- L-687,384
- Lu 28-179
- MDMA
- Metaphit
- Methamphetamine
- Methoxetamine
- Methylphenidate
- Morphine
- Naluzotan
- Noscapine
- OPC-14,523
- Opipramol
- Panamesine
- PB-28
- PD-144,415
- Pentazocine
- Pentoxyverine
- Phencyclidine
- PRE-084
- Pregnenolone
- Pregnenolone sulfate
- RTI-55
- SA-4503
- Siramesine
- Tenocyclidine
- Venlafaxine
- Antagonists: BD-1,047
- BD-1,063
- BMY-14,802
- E-5,842
- Haloperidol
- Lamotrigine
- MIN-101
- NE-100
- Progesterone
- Rimcazole
- S1RA (E-52862)
- Sertraline
- SM-21
- Unknown/unsorted: 4C-T-2
- 5-MeO-DiPT
- 18-MC
- β-Endopsychosin
- Clocapramine
- DiPT
- DPT
- Gevotroline
- Ibogaine
- Noribogaine
- TMA; Allosteric modulators: SKF-83,959
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English Journal
- [Determination of dimemorfan in human plasma and urine with HPLC-MS/MS].
- Wang SJ, Xiang J, Yu Q, Liang MZ, Nan F, Qin YP.
- Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.Sichuan Da Xue Xue Bao Yi Xue Ban.2014 May;45(3):497-501.
- OBJECTIVE: To develop a sensitive and reproducible HPLC-MS/MS method for analyzing dimemorfan in human plasma and urine.METHODS: Dimemorfan was extracted from plasma and urine by redistilled ether, with lidocaine serving as the internal standard (IS). The analysis was performed on a column of ultima
- PMID 24941827
- A new method for quantitative determination of dimemorfan in human plasma using monolithic silica solid-phase extraction tips.
- Hasegawa C1, Kumazawa T, Terada M, Lee XP, Sato K, Uchigasaki S, Kurosaki K.
- Legal medicine (Tokyo, Japan).Leg Med (Tokyo).2012 Sep;14(5):267-71. doi: 10.1016/j.legalmed.2012.03.004. Epub 2012 Apr 28.
- Dimemorfan was extracted from human plasma samples (100 μL) using MonoTip C(18) tips, which were packed with a C(18)-bonded monolithic silica gel attached to the inside of the tip. The samples, which contained dimemorfan and trimeprazine as an internal standard (IS), were mixed with 300 μL of dist
- PMID 22546247
- Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs.
- Shin EJ1, Bach JH, Lee SY, Kim JM, Lee J, Hong JS, Nabeshima T, Kim HC.
- Journal of pharmacological sciences.J Pharmacol Sci.2011;116(2):137-48. Epub 2011 May 21.
- Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan
- PMID 21606622
Japanese Journal
- Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs
- Shin Eun-Joo,Bach Jae-Hyung,Lee Sung Youl [他],KIM Jeong Min,LEE Jinhwa,HONG Jau-Shyong,NABESHIMA Toshitaka,KIM Hyoung-Chun
- Journal of pharmacological sciences 116(2), 137-148, 2011-06-20
- … Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. …
- NAID 10029894272
- Concise Synthesis of Dimemorfan (DF) Starting from 3-Hydroxymorphinan (3-HM)
- Kim Jong Yup,Kim Hyoung-Chun,Kim Jeongmin [他],LEE Jinhwa
- Chemical & pharmaceutical bulletin 56(7), 985-987, 2008-07-01
- … Dimemorfan (DF) has been known to possess neuroprotective properties. …
- NAID 110006791981
- Plasma-Polymerized Membrane Electrode for the Determination of Dextromethorphan and Dimemorfan
- 櫨本 紀夫,石坂 真悟,芳賀 信,加藤 百合子,黒沢 茂,加茂 直樹,小畠 陽之助
- Chemical & pharmaceutical bulletin 37(8), 2153-2154, 1989-08-25
- … Ion-selective electrodes (ISEs) responsive to the antitussives dextromethorphan and dimemorfan were constructed by the fixation of an ion-exchanger, ammonium tetraphenylborate, on a Millipore membrane by means of a plasma-polymerization technique. …
- NAID 110003627941
Related Links
- Dimemorfan Phosphate Tablets Dissolution <6.10> Perform the test with 1 tablet of Dimemorfan Phosphate Tablets at 50 revolutions per minute according to the Paddle method, using 900 mL of water as the dissolution medium.
- The aims of the present investigation were to compare the dissolution properties of dimemorfan phosphate and dimemorfan and to control the dissolution of dimemorfan species, which are pharmacologically equivalent, by using ...
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