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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/15 09:45:42」(JST)

Dimaprit is a histamine analog working as a selective H₂ histamine receptor agonist.^[1]^[2]^[3]

References

^ Kartzung, Betram G.; Trevor, Anthony J., eds. (2014). Basic and Clinical Pharmacology (13th ed.). New York: McGraw-Hill Education. p. 364. ISBN 0071825053. |access-date= requires |url= (help)
^ Kohno, S; Ogawa, K; Nabe, T; Yamamura, H; Ohata, K (May 1993). "Dimaprit, a Histamine H₂-agonist, Inhibits Anaphylactic Histamine Release from Mast Cells and the Decreased Release is Restored by Thioperamide (H₃-antagonist), but not by Cimetidine (H₂-antagonist)". Japanese Journal of Pharmacology 62 (1): 75–9. PMID 7688057. |access-date= requires |url= (help)
^ Nakamura, T; Ueno, Y; Goda, Y; Nakamura, A; Shinjo, K; Nagahisa, A (March 1997). "Efficacy of a Selective Histamine H₂ Receptor Agonist, Dimaprit, in Experimental Models of Endotoxin Shock and Hepatitis in Mice". European Journal of Pharmacology 322 (1): 83–89. doi:10.1016/S0014-2999(96)00987-9. |access-date= requires |url= (help)

Role of the thalamic submedius nucleus histamine H1 and H 2 and opioid receptors in modulation of formalin-induced orofacial pain in rats.

Erfanparast A1, Tamaddonfard E, Taati M, Dabaghi M.
Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2015 Jun 16. [Epub ahead of print]
Histamine and opioid systems are involved in supraspinal modulation of pain. In this study, we investigated the effects of separate and combined microinjections of agonists and antagonists of histamine H1 and H2 and opioid receptors into the thalamic submedius (Sm) nucleus on the formalin-induced or
PMID 26077661

Gemba C1, Nakayama K2, Nakamura S2, Mochizuki A2, Inoue M3, Inoue T2.
Journal of neurophysiology.J Neurophysiol.2015 Jun 1;113(10):3720-35. doi: 10.1152/jn.00515.2014. Epub 2015 Apr 22.
Histamine receptors are densely expressed in the mesencephalic trigeminal nucleus (MesV) and trigeminal motor nucleus. However, little is known about the functional roles of neuronal histamine in controlling oral-motor activity. Thus, using the whole-cell recording technique in brainstem slice prepa
PMID 25904711

Gianlorenço AC1, Riboldi AM2, Silva-Marques B3, Mattioli R4.
Neuroscience letters.Neurosci Lett.2015 Feb 5;587:57-61. doi: 10.1016/j.neulet.2014.12.017. Epub 2014 Dec 15.
Histaminergic fibers are present in the molecular and granular layers of the cerebellum and have a high density in the vermis and flocullus. Evidence supports that the cerebellar histaminergic system is involved in memory consolidation. Our recent study showed that histamine injections facilitate th
PMID 25524412

Cytokine responses of intraepithelial lymphocytes are regulated by histamine H2 receptor

Effects of activation of central nervous histamine receptors in cardiovascular regulation; studies in H1 and H2 receptor gene knockout mice

Curcuma longa Extract Protects against Gastric Ulcers by Blocking H_2 Histamine Receptors(Pharmacology)

Dimaprit
Names
	IUPAC name 3-(dimethylamino)propyl carbamimidothioate
	Other names 3-dimethylaminopropyl sulfanylmethanimidamide
Identifiers
CAS Number	65119-89-3
ChEMBL	ChEMBL12344
ChemSpider	2968
IUPHAR/BPS	1248
Jmol interactive 3D	Image
KEGG	C17930
PubChem	3077
UNII	ZZQ699148P
	InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) Key: OLHQOJYVQUNWPL-UHFFFAOYSA-N ; InChI=1/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) Key: OLHQOJYVQUNWPL-UHFFFAOYAQ ;
	SMILES CN©CCCSC(=N)N ;
Properties
Chemical formula	C6H15N3S
Molar mass	161.2684 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references