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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/29 13:57:26」(JST)

Clobenpropit is a histamine H₃ receptor antagonist.^[1] It has neuroprotective effects via stimulation of GABA release in the brain.^[2]

References[edit]

^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.
^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology 563 (1-3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.

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Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.

Femenía T1, Magara S1, DuPont CM1, Lindskog M2.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2015 Mar 11;18(9). pii: pyv032. doi: 10.1093/ijnp/pyv032.
BACKGROUND: Histamine is a modulatory neurotransmitter regulating neuronal activity. Antidepressant drugs target modulatory neurotransmitters, thus ultimately regulating glutamatergic transmission and plasticity. Histamine H3 receptor (H3R) antagonists have both pro-cognitive and antidepressant effe
PMID 25762718

Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer.

Martinel Lamas DJ1, Cortina JE, Ventura C, Sterle HA, Valli E, Balestrasse KB, Blanco H, Cremaschi GA, Rivera ES, Medina VA.
Cancer biology & therapy.Cancer Biol Ther.2015;16(1):137-48. doi: 10.4161/15384047.2014.987091.
The radioprotective potential of histamine on healthy tissue has been previously demonstrated. The aims of this work were to investigate the combinatorial effect of histamine or its receptor ligands and gamma radiation in vitro on the radiobiological response of 2 breast cancer cell lines (MDA-MB-23
PMID 25482934

R-(?)-α-Methylhistamine, a Histamine H3 Receptor Agonist, Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries

Sun Pengyuan,Jin Xin,Koyama Toshihiro,Li Simin,Kitamura Yoshihisa,Kawasaki Hiromu
Biological & Pharmaceutical Bulletin 33(1), 58-63, 2010
… This vasodilation was abolished by endothelium removal and attenuated by histamine H3 receptor antagonists, thioperamide and clobenpropit, but not by chlorpheniramine (histamine H1 receptor antagonist) and cimetidine (histamine H2 receptor antagonist). …
NAID 130000140192

Clobenpropit
Systematic (IUPAC) name
	N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine
Clinical data
Legal status	?
Identifiers
CAS number	145231-45-4
ATC code	None
PubChem	CID 2790
IUPHAR ligand	1223
ChemSpider	2688
ChEMBL	CHEMBL14690
Chemical data
Formula	C14H17ClN4S
Mol. mass	308.83 g/mol
	SMILES C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl;