WordNet

the 16th letter of the Roman alphabet (同)p
(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)
a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River

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1. 薬理ゲノム学の概要 overview of pharmacogenomics
2. 基底細胞癌の疫学、発症機序、臨床的特徴 epidemiology pathogenesis and clinical features of basal cell carcinoma
3. 薬と肝臓：代謝および肝障害の機序 drugs and the liver metabolism and mechanisms of injury
4. 選択的エストロゲン受容体モジュレーター・受容体ダウンレギュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators and down regulators
5. スタチン：作用、副作用、および投与 statins actions side effects and administration

Weaver JM.
Anesthesia progress.Anesth Prog.2013 Summer;60(2):35-6. doi: 10.2344/0003-3006-60.2.35.
PMID 23763556

Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation.

Geier M, Braun A, Fladischer P, Stepniak P, Rudroff F, Hametner C, Mihovilovic MD, Glieder A.SourceInstitute of Molecular Biotechnology, Graz University of Technology, Graz, Austria.
The FEBS journal.FEBS J.2013 Jul;280(13):3094-108. doi: 10.1111/febs.12270. Epub 2013 May 3.
The human cytochrome P450 2D6 (CYP2D6) is one of the major human drug metabolizing enzymes and acts preferably on substrates containing a basic nitrogen atom. Testosterone - just as other steroids - is an atypical substrate and only poorly metabolized by CYP2D6. The present study intended to investi
PMID 23552177

First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo.

Zhou K, Khokhar JY, Zhao B, Tyndale RF.SourceDepartments of Pharmacology & Toxicology and Psychiatry, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Biochemical pharmacology.Biochem Pharmacol.2013 Jun 15;85(12):1848-55. doi: 10.1016/j.bcp.2013.04.014. Epub 2013 Apr 23.
The response to centrally acting drugs is highly variable between individuals and does not always correlate with plasma drug levels. Drug-metabolizing CYP enzymes in the brain may contribute to this variability by affecting local drug and metabolite concentrations. CYP2D metabolizes codeine to the a
PMID 23623752

家入一郎
Organ Biology 21(2), 247-253, 2014
… Genetic polymorphism in drug metabolizing enzymes and drug transporters has been focused on currently, especially for cytochrome P-450s (CYPs, such as CYP2C9, CYP2C19, and CYP2D6), and organic anion transporting polypeptides 1B1(OATP1B1)and pglycoprotein, respectively, are available in various clinical situations. …
NAID 130004715813

抗cytochrome P 450 2D6抗体(CYP2D6抗体) (広範囲血液・尿化学検査免疫学的検査(第7版・3)その数値をどう読むか) -- (免疫学的検査自己抗体)

Effect of Equisetum arvense L. Extract on Cytochrome P-450 Activities in Human Liver Microsomes and Prediction of Interaction with Blood Drug Metabolism

安達弥永,安保智子,藤島美紀,渡邊治夫
生活衛生 54(2), 137-145, 2010
… extract) on the metabolic activities of drugs with specific activity on cytochrome P-450 isozymes (1A2, 2C9, 2C19, 2D6, 2E1, and 3A4) were investigated using human liver microsomes. … Although CYP2D6 and CYP2E retained 66.7% and 73.4% of activity at <I>Equisetum</I> …
NAID 130004448996